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Kallikrein-related peptidase 11

hK11, KLK11, kallikrein 11, TLSP
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: Kallikrein, KLK6, KLK14, HNP, HAD
Papers on hK11
Diagnostic Importance of Selected Protein Serum Markers in the Primary Diagnostics of Prostate Cancer.
New
Hanuš et al., Praha, Czech Republic. In Urol Int, Dec 2015
Serum or plasma concentrations of 22 biomarkers (neopterin, IGF-1, IGFBP-2, IGFBP-3, sarcosine, endoglin, TGF-β1, periostin, sPLA2-IIa, chromogranin A, ZAG2, clusterin, PSP94, PSP94bp, leptin, cathepsin D, hepsin, KLK11, PSMA, AMACR, CRISP3 and A1AT) were determined.
Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.
New
Yousef et al., Toronto, Canada. In Tumour Biol, Aug 2015
Expression of KLK11 and KLK15 was assessed by immunohistochemistry staining on a tissue microarray constructed from 113 gastrectomy specimens from patients with gastric carcinoma.
Is Human Kallikrein 11 in Non-small Cell Lung Cancer Treated Chemoradiotherapy Associated with Survival?
New
Kaplan et al., Kayseri, Turkey. In Cancer Res Treat, Apr 2015
The aim of this study was to evaluate the prognostic significance of hK11 expression in patients with non-metastatic non-small cell lung cancer (NSCLC).
Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the kinin B₁ receptor in breast cancer cells.
Figueroa et al., Valdivia, Chile. In Anticancer Res, 2014
Furthermore, we investigated whether stimulation of breast cancer cells with a B1R agonist would modify the cellular levels of KLK6, KLK10 and KLK11, three kallikrein-related peptidases with a still poorly-understood biological role in breast cancer.
A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa.
Baekkevold et al., Oslo, Norway. In J Allergy Clin Immunol, 2014
However, the observation that TH2 cytokines abrogate the induction of CCR7 implies that during a TH2-mediated inflammatory reaction, TLSP-activated CD1c(+) DCs are retained in the inflamed tissue to further exacerbate local inflammation by activating local antigen-specific memory TH2 cells.
Low mRNA expression levels of kallikrein-related peptidase 4 (KLK4) predict short-term relapse in patients with laryngeal squamous cell carcinoma.
Scorilas et al., In Biol Chem, 2014
However, only one (KLK11) has already been studied in laryngeal squamous cell carcinoma (LSCC) as a potential biomarker for LSCC diagnosis and/or prognosis.
The diagnostic and prognostic value of serum human kallikrein-related peptidases 11 in non-small cell lung cancer.
Yu et al., Nanjing, China. In Tumour Biol, 2014
The aim of this study was to explore the diagnostic and prognostic value of serum human kallikrein-related peptidases 11 (KLK11) level in non-small cell lung cancer (NSCLC).
Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile.
Menendez et al., Girona, Spain. In Cell Cycle, 2013
Intriguingly, acquired resistance to metformin appears to trigger a transcriptome reprogramming toward a metastatic stem-like profile, as many genes encoding the components of the degradome (KLK11, CTSF, FREM1, BACE-2, CASP, TMPRSS4, MMP16, HTRA1), cancer cell migration and invasion factors (TP63, WISP2, GAS3, DKK1, BCAR3, PABPC1, MUC1, SPARCL1, SEMA3B, SEMA6A), stem cell markers (DCLK1, FAK), and key pro-metastatic lipases (MAGL and Cpla2) were included in the signature.
KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients.
Scorilas et al., Athens, Greece. In Biomark Med, 2013
In the present study, the prognostic value of KLK11 mRNA expression as a molecular tissue biomarker in colorectal adenocarcinoma was examined.
Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11).
Feldman et al., Pretoria, South Africa. In Biomed Res Int, 2013
upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation.
Diagnostic and prognostic significance of human kallikrein 11 (KLK11) mRNA expression levels in patients with laryngeal cancer.
GeneRIF
Scorilas et al., Athens, Greece. In Clin Biochem, 2012
Patients harboring KLK11-positive tumors had a significantly decreased risk of death.
Identification and validation of Kallikrein-ralated peptidase 11 as a novel prognostic marker of gastric cancer based on immunohistochemistry.
GeneRIF
Peng et al., Shanghai, China. In J Surg Oncol, 2011
Low KLK11 protein expression is associated with gastric cancer.
The regulation of thymic stromal lymphopoietin in gut immune homeostasis.
Review
Li et al., Chongqing, China. In Dig Dis Sci, 2011
Thus, we sought to examine the relationship between the TLSP-TSLPR pathway and inflammation in hopes of contributing to the search for a novel therapeutic target to treat a variety of inflammatory diseases, including inflammatory bowel disease.
Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients.
GeneRIF
Bouchal et al., Olomouc, Czech Republic. In Neoplasma, 2010
For the first time, we report lower expression of KLK11 in CaP compared to BPH and slight upregulation of KLK11 in advanced tumors compared to localized ones
The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer.
GeneRIF
Diamandis et al., Toronto, Canada. In Clin Biochem, 2009
Data show that it was unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers.
Androgens act synergistically to enhance estrogen-induced upregulation of human tissue kallikreins 10, 11, and 14 in breast cancer cells via a membrane bound androgen receptor.
GeneRIF
Diamandis et al., Toronto, Canada. In Mol Oncol, 2008
synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression.
Human tissue kallikreins: the cancer biomarker family.
Review
Diamandis et al., Toronto, Canada. In Cancer Lett, 2007
Several other kallikreins, including kallikreins 2 (KLK2) and 11 (KLK11) are emerging as complementary prostate cancer biomarkers.
Human tissue kallikrein gene family: applications in cancer.
Review
Diamandis et al., Toronto, Canada. In Cancer Lett, 2005
For example, hK4, hK5, hK6, hK7, hK8, hK10, hK11, hK13 and hK14 are emerging biomarkers for ovarian, breast, prostate and testicular cancer.
Human tissue kallikreins: a family of new cancer biomarkers.
Review
Yousef et al., Toronto, Canada. In Clin Chem, 2002
Three other kallikreins, hK6, hK10, and hK11, are emerging new serum biomarkers for ovarian and prostate cancer diagnosis and prognosis.
Expanded human tissue kallikrein family--a novel panel of cancer biomarkers.
Review
Diamandis et al., Toronto, Canada. In Tumour Biol, 2002
In addition, preliminary reports indicate that three newly identified kallikreins (hK6, hK10 and hK11) are serum biomarkers for diagnosis and monitoring of ovarian and prostate cancer.
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