O'Connor et al., Colombia. In Clin Cancer Res, 29 Nov 2014
UNLABELLED: Purpose: To evaluate the pharmacologic activity of a novel inhibitor of IkB kinase beta (IKK2), LY2409881, in preclinical models of B- and T- cell lymphoma, as a single agent and in combination with histone deacetylase (HDAC) inhibitors.
Zhao et al., Chicago, United States. In Cell, 09 Nov 2014
Histone proteins are decorated by a variety of protein posttranslational modifications called histone marks that modulate chromatin structure and function, contributing to the cellular gene expression program.
Sweatt et al., Birmingham, United States. In Nature, 14 Oct 2014
Here we show that histone H2A.Z, a variant of histone H2A, is actively exchanged in response to fear conditioning in the hippocampus and the cortex, where it mediates gene expression and restrains the formation of recent and remote memory.
Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand.
Workman et al., Kansas City, United States. In Science, 2005
demonstrated that the dTip60 chromatin-remodeling complex acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av; both the histone acetyltransferase dTip60 and the atpase Domino/p400 catalyze the exchange of phospho-H2Av
... murine anti-clathrin monoclonal antibody from Santa-Cruz Biotechnology (Santa-Cruz, CA, USA), rabbit anti-Histone H3 and rabbit anti-phospho-Histone H3 (Ser10) polyclonal antibodies from Cell Signaling (Danvers, MA, USA) and ...