Histone Profiles in Cancer.
Aurora, United States. In Pharmacol Ther, 22 Aug 2015
In parallel, technical advances have greatly enhanced our ability to perform comprehensive chromatin/histone profiling.
Histone deacetylases and cardiovascular cell lineage commitment.
Guangzhou, China. In World J Stem Cells, 26 Jul 2015
Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups from lysine residues of histone proteins allowing the histones to wrap the DNA more tightly and commonly known as epigenetic regulators of gene transcription.
Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
Cambridge, United Kingdom. In Nature, 11 Jul 2015
Recent studies have demonstrated that a subset of transposable elements, endogenous retroviral elements (ERVs) containing long terminal repeats (LTRs), are silenced through trimethylation of histone H3 on lysine 9 (H3K9me3) by ESET (also known as SETDB1 or KMT1E) and a co-repressor complex containing KRAB-associated protein 1 (KAP1; also known as TRIM28) in mouse embryonic stem cells.
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.
More papers using
United States. In Nat Rev Cancer, 30 Jun 2015
Histone-lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone H3 tail at important regulatory regions in the genome and thereby impart crucial functions through modulating chromatin structures and DNA accessibility.