Furthermore, 11c simultaneously increased the acetylation of histone H3 and α-tubulin, enhanced DNA damage markers histone H2AX phosphorylation and p-p53 (Ser15) expression, and activated p53 signaling pathway in HCT116 cells.
Mailand et al., Copenhagen, Denmark. In Nature, 21 Nov 2015
These results identify histone H1 as a key target of RNF8-UBC13 in DSB signalling and expand the concept of the histone code by showing that posttranslational modifications of linker histones can serve as important marks for recognition by factors involved in genome stability maintenance, and possibly beyond.
Rubio et al., Milano, Italy. In Curr Opin Genet Dev, 15 Nov 2015
Although the genetic network of transcription factors (TFs) required for neural specification has been well characterized, the unique set of histone modifications that accompanies this process has only recently started to be investigated.
Sugimoto et al., Yokohama, Japan. In Curr Opin Plant Biol, 08 Nov 2015
What has recently emerged as an additional important regulatory layer is the control at the epigenetic level by which locus-specific DNA methylation and histone modification alter the chromatin state and limit the expression of key developmental regulators to specific windows of time and space.
Zhu et al., Changchun, China. In Plos One, Dec 2014
In this study, we developed a receptor-mediated gene delivery system based on a combination of the Pseudomonas exotoxin A (PE), which has a receptor binding and membrane translocation domain, and the hyperthermophilic archaeal histone (HPhA), which has the DNA binding ability.
Workman et al., Kansas City, United States. In Science, 2005
demonstrated that the dTip60 chromatin-remodeling complex acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av; both the histone acetyltransferase dTip60 and the atpase Domino/p400 catalyze the exchange of phospho-H2Av
... murine anti-clathrin monoclonal antibody from Santa-Cruz Biotechnology (Santa-Cruz, CA, USA), rabbit anti-Histone H3 and rabbit anti-phospho-Histone H3 (Ser10) polyclonal antibodies from Cell Signaling (Danvers, MA, USA) and ...