HDAC8: a multifaceted target for therapeutic interventions.
Freiburg, Germany. In Trends Pharmacol Sci, 23 Jun 2015
UNASSIGNED: Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections.
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.
United States. In Nat Rev Cancer, 22 Jun 2015
Histone-lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone H3 tail at important regulatory regions in the genome and thereby impart crucial functions through modulating chromatin structures and DNA accessibility.
Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
Cambridge, United Kingdom. In Nature, 04 Jun 2015
Recent studies have demonstrated that a subset of transposable elements, endogenous retroviral elements (ERVs) containing long terminal repeats (LTRs), are silenced through trimethylation of histone H3 on lysine 9 (H3K9me3) by ESET (also known as SETDB1 or KMT1E) and a co-repressor complex containing KRAB-associated protein 1 (KAP1; also known as TRIM28) in mouse embryonic stem cells.
Initiation of Meiotic Homologous Recombination: Flexibility, Impact of Histone Modifications, and Chromatin Remodeling.
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Debrecen, Hungary. In Cold Spring Harb Perspect Biol, Dec 2014
Predisposed chromatin accessibility, but also a range of transcription factors, chromatin remodelers, and histone modifiers likely promote local recruitment of DSB proteins, as well as mobilization, sliding, and eviction of nucleosomes before and after the occurrence of meiotic DSBs.