Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.
Philadelphia, United States. In Nature, 03 Dec 2013
Here we demonstrate that mice with an intestinal epithelial cell (IEC)-specific deletion of the epigenome-modifying enzyme histone deacetylase 3 (HDAC3(ΔIEC) mice) exhibited extensive dysregulation of IEC-intrinsic gene expression, including decreased basal expression of genes associated with antimicrobial defence.
Macromolecular interactions with cadmium and the effects of zinc, copper, lead, and mercury ions.
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Logan, United States. In Biol Trace Elem Res, 1982
Interactions of cadmium (Cd) ions with bovine serum albumin (BSA), bovine hepatic metallothionein (MT), calf thymus histone and deoxyribonucleic acid (DNA), and bovine hepatic chromatins were studied in the presence and absence of divalent zinc (Zn), copper (Cu), mercury (Hg), or lead (Pb) ions, using equilibrium dialysis at pH 7 and at 37°C.