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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Histone deacetylase 4

histone deacetylase, HDAC4, HDAC5
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, HDAC, CAN, ACID, V1a
Papers using histone deacetylase antibodies
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
Oshima Robert, In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications
Supplier
Bai Wenlong et al., In Oncogene, 2004
... Louis, MO), anti-HDAC4 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-SUMO1 ...
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain
Supplier
Casaccia-Bonnefil Patrizia et al., In The Journal of Cell Biology, 2002
... for WB; Santa Cruz Biotechnology, Inc.); HDAC4 (1:100 for IHC, 1:1,000 for WB; Upstate Biotechnology); HDAC5 (1:100 for IHC, 1:500 for WB; Santa Cruz Biotechnology, Inc.); HDAC6 (1:100 for ...
Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
Supplier
Nurminsky Dmitry I., In PLoS ONE, 2002
... Vimentin (Santacruz, sc73259, Actin (Santacruz, sc-1615), Nucleolin (Santacruz, sc13057), Lamin A (Santacruz, sc-20680), MEF2C (Abcam, ab65252), HDAC4 (Cell Signaling, #2072), HAND2 (Abcam, ab56590), ...
Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway
Supplier
Avkiran Metin et al., In Basic Research in Cardiology, 1995
... cTnI were from Cell Signaling Technology, PLB and pSer16 PLB were from Badrilla, and pSer498 HDAC5 was from Abcam.
Papers on histone deacetylase
Epigenetic Regulation of the Blimp-1 Gene in B Cells Involves Bach2 and Histone Deacetylase 3.
New
Igarashi et al., Japan. In J Biol Chem, Feb 2016
Purification of Bach2 complex in BAL17 cells revealed its interaction with histone deacetylase 3 (HDAC3), nuclear co-repressors NCoR1 and NCoR2, transducin beta-like 1X-linked (Tbl1x), and RAP1 interacting factor homolog (Rif1).
Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple negative breast cancer.
New
Sukumar et al., Hopkins, United States. In Cancer Res, Feb 2016
The histone deacetylase inhibitor, entinostat, is emerging as a promising antitumor agent when added to the standard of care treatment for breast cancer.
UGT genotyping in belinostat dosing.
Review
New
Figg et al., Bethesda, United States. In Pharmacol Res, Feb 2016
This review presents an overview of the clinical effects of UGT1A1 polymorphisms on the pharmacology of UGT1A1 substrates, with a special focus on the novel histone deacetylase inhibitor belinostat.
Molecular mechanisms of HIV latency.
Review
New
Peterlin et al., In J Clin Invest, Feb 2016
These proposed therapies include PKC and MAPK agonists as well as histone deacetylase inhibitors (HDACis) and bromodomain and extraterminal (BET) bromodomain inhibitors (BETis), which act synergistically to reactivate HIV in latently infected cells.
Advances in GBA-associated Parkinson's disease - pathology, presentation and therapies.
Review
New
Grobler et al., Potchefstroom, South Africa. In Neurochem Int, Jan 2016
This underlies the therapeutic efficacy of certain pharmacological chaperones and histone deacetylase inhibitors.
Overcoming Barriers in Oncolytic Virotherapy with HDAC Inhibitors and Immune Checkpoint Blockade.
Review
New
Rommelaere et al., Heidelberg, Germany. In Viruses, Dec 2015
In this review, we consider the use of histone deacetylase (HDAC) inhibitors as a means of boosting virus replication and lessening the negative impact of innate immunity on the direct oncolytic effect.
Epigenetic changes and nuclear factor-κB activation, but not microRNA-224, downregulate Raf-1 kinase inhibitor protein in triple-negative breast cancer SUM 159 cells.
New
Notarbartolo et al., Palermo, Italy. In Oncol Lett, Dec 2015
Furthermore, reverse transcription-quantitative PCR, western blotting, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium cell growth assay and flow cytometry revealed that in SUM 159 cells, the demethylating agent 5-aza-2'-deoxycytidine (5-AZA), the histone deacetylase inhibitor trichostatin A (TSA) and the NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) enhanced RKIP expression and resulted in significant cell growth inhibition and induction of apoptosis.
Effect on Multipotency and Phenotypic Transition of Unrestricted Somatic Stem Cells from Human Umbilical Cord Blood after Treatment with Epigenetic Agents.
New
Santourlidis et al., Düsseldorf, Germany. In Stem Cells Int, Dec 2015
Here we document that USSCs drastically change their phenotype after treatment by a new elaborated cultivation protocol which utilizes the DNA hypomethylating compound 5'-aza-2-deoxycytidine (5-Aza-CdR) and the histone deacetylase inhibitor trichostatin A (TSA).
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation.
New
Impact
Kuo et al., Duarte, United States. In Cell Stem Cell, Dec 2015
Here, we show that p53 activity is inhibited in inv(16)(+) AML LSCs via interactions with the CBFβ-SMMHC (CM) fusion protein and histone deacetylase 8 (HDAC8).
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema.
New
Impact
Corry et al., Houston, United States. In Nat Immunol, Nov 2015
We further found that miR-22 controlled the activation of APCs and T(H)17 responses through the activation of AP-1 transcription factor complexes and the histone deacetylase HDAC4.
Profiling technologies for the identification and characterization of small-molecule histone deacetylase inhibitors.
Review
New
Liao, Gainesville, United States. In Drug Discov Today Technol, Nov 2015
Histone deacetylases (HDACs) are promising drug targets for treating cancer, neurologic, inflammatory and metabolic diseases.
β-Peptoid Foldamers at Last.
New
Impact
Olsen et al., Copenhagen, Denmark. In Acc Chem Res, Nov 2015
Introduction of β-peptoid residues in histone deacetylase inhibitors mimicking nonribosomal cyclotetrapeptides have also been reported.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
New
Impact
Siveke et al., Stanford, United States. In Nat Med, Oct 2015
The histone deacetylase (HDAC) inhibitor SAHA synergizes with JQ1 to augment cell death and more potently suppress advanced PDAC.
Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study.
New
Impact
Shustov et al., Budapest, Hungary. In J Clin Oncol, Sep 2015
This study evaluated the efficacy and tolerability of belinostat, a novel histone deacetylase inhibitor, as a single agent in relapsed or refractory PTCL.
Protective effect of valproic acid on cultured motor neurons under glutamate excitotoxic conditions. Ultrastructural study.
Rafałowska et al., Warsaw, Poland. In Folia Neuropathol, 2014
The real mechanisms underlying numerous beneficial effects of VPA are complex, but recently it has been postulated that the neuroprotective properties might be related to direct inhibition of histone deacetylase (HDAC).
Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4).
GeneRIF
Schiaffino et al., Milano, Italy. In Proc Natl Acad Sci U S A, 2012
Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4
Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function.
GeneRIF
Kumar et al., Washington, D.C., United States. In J Biol Chem, 2012
Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function.
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation.
GeneRIF
Monteggia et al., Dallas, United States. In J Neurosci, 2012
The resuklts of this study suggested that HDAC4 is a crucial positive regulator of learning and memory, both behaviorally and at the cellular level, and that inhibition of Hdac4 activity may have unexpected detrimental effects to these processes.
HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration.
GeneRIF
Cavalli et al., Saint Louis, United States. In Embo J, 2012
HDAC5 as a novel injury-regulated tubulin deacetylase that plays an essential role in growth cone dynamics and axon regeneration.
A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program.
GeneRIF
Yao et al., Durham, United States. In Mol Cell, 2012
Data show that HDAC4 binds and promotes the deacetylation and activation of a key MAP3 kinase, MEKK2.
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