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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

K

histone acetyltransferase, MORF
The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: Histone, N-acetyl-beta-D-glucosaminidase, p300, CAN, CBP
Papers on histone acetyltransferase
Regulation of antisense transcription by NuA4 histone acetyltransferase and other chromatin regulatory factors.
New
Bhaumik et al., Carbondale, United States. In Mol Cell Biol, Feb 2016
UNASSIGNED: NuA4 histone lysine (K) acetyltransferase (KAT) promotes transcriptional initiation of TAF (TBP-associated factor)-dependent ribosomal protein genes.
The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase.
New
Yeh et al., Shancheng, China. In Toxicol Appl Pharmacol, Feb 2016
UNASSIGNED: Genistein has been shown to enhance the antitumor activity of trichostatin A (TSA) in human lung carcinoma A549 cells.
Pharmacological priming of adipose-derived stem cells promotes myocardial repair.
New
Hill et al., Dallas, United States. In J Investig Med, Jan 2016
ISX1 treatment increased histone acetyltransferase (HAT) activity in ADSCs, which was associated with histone 3 and histone 4 acetylation.
Are epigenetic drugs for diabetes and obesity at our door step?
Review
New
Choudhury et al., Kingsville, United States. In Drug Discov Today, Jan 2016
These classes include histone deacetylase inhibitors (HDACi), histone acetyltransferase inhibitors (HATi), protein arginine methyltransferase inhibitors (PRMTis), DNA methyltransferase inhibitors (DNMTis), histone demethylating inhibitors (HDMis), and sirtuin-activating compounds (STACs).
Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice.
New
Brindle et al., Memphis, United States. In Plos One, Dec 2015
Mutations in the histone acetyltransferase CREB binding protein (CBP, CREBBP) cause Rubinstein-Taybi Syndrome (RTS), a developmental disorder that includes ASD-like symptoms.
Histone modification and chromatin remodeling during NER.
Review
New
Reed et al., Cardiff, United Kingdom. In Dna Repair (amst), Dec 2015
We focused on how GG-NER relates to histone acetylation for its functioning and we identified the histone acetyltransferase Gcn5 and acetylation at lysines 9/14 of histone H3 as a major factor in enabling efficient repair.
hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers.
New
Deng et al., Xinhui, China. In Mol Oncol, Dec 2015
Exogenous overexpression of p300, but not its histone acetyltransferase (HAT) domain deletion mutation, augmented the acetylation of hnRNPA2/B1 and enhanced its binding on COX-2 promoter, thereby promoted COX-2 expression and lung cancer cell growth.
Bromodomains: Translating the words of lysine acetylation into myelin injury and repair.
Review
New
Casaccia et al., New York City, United States. In Neurosci Lett, Nov 2015
Bromodomain-containing proteins can have a wide variety of functions, ranging from histone acetyltransferase activity and chromatin remodeling to transcriptional mediation and co-activation.
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis.
Review
Wang et al., Miami, United States. In Front Oncol, 2014
Here, we will review the function of HATs such as p300/CBP, Tip60, MOZ/MORF, and GCN5/PCAF in normal hematopoiesis and the pathogenesis of hematological malignancies.
The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis.
Review
Jin et al., Changchun, China. In Int J Mol Sci, 2014
Changes in chromatin structure and heritably regulating the gene expression by epigenetic mechanisms, such as histone post-translational modification, are involved in most cellular biological processes.
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.
Impact
Puigserver et al., Boston, United States. In Nature, 2014
The histone acetyltransferase GCN5 (general control non-repressed protein 5) acetylates PGC-1α and suppresses its transcriptional activity, whereas sirtuin 1 deacetylates and activates PGC-1α.
Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions.
Impact
Wang et al., Jena, Germany. In Cell Stem Cell, 2014
Here, we show that the histone acetyltransferase (HAT) cofactor transformation/transcription domain-associated protein (Trrap) specifically regulates activation of cell-cycle genes, thereby integrating discrete cell-intrinsic programs of cell-cycle progression and epigenetic regulation of gene transcription in order to control neurogenesis.
Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes.
Impact
Brand et al., Ottawa, Canada. In Cell Stem Cell, 2014
At the mechanistic level, we show that TAL1 upregulates the expression of migratory and adhesion genes through recruitment of the histone acetyltransferase p300.
Nucleosome-free region dominates histone acetylation in targeting SWR1 to promoters for H2A.Z replacement.
Impact
Wu et al., Bethesda, United States. In Cell, 2013
SWR1 binding is enhanced on nucleosomes acetylated by the NuA4 histone acetyltransferase, but recognition of nucleosome-free and nucleosomal DNA is dominant over interaction with acetylated histones.
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.
Impact
Joseph et al., Stockholm, Sweden. In Nature, 2013
Here we report that induction of autophagy is coupled to reduction of histone H4 lysine 16 acetylation (H4K16ac) through downregulation of the histone acetyltransferase hMOF (also called KAT8 or MYST1), and demonstrate that this histone modification regulates the outcome of autophagy.
Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome.
GeneRIF
Lee et al., Houston, United States. In Am J Hum Genet, 2012
By exome sequencing, we found de novo heterozygous truncating mutations in KAT6B.
De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome.
GeneRIF
Trembath et al., London, United Kingdom. In Am J Hum Genet, 2012
we identified de novo mutations of KAT6B in five individuals with Genitopatellar syndrome.
Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome.
GeneRIF
Black et al., Manchester, United Kingdom. In Am J Hum Genet, 2011
Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome
Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).
GeneRIF
Shi et al., Hefei, China. In J Biol Chem, 2011
Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).
Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.
GeneRIF
Thiel et al., Erlangen, Germany. In J Clin Invest, 2011
Data show that H3 acetylation by Myst4 is important for neural, craniofacial, and skeletal morphogenesis, mainly through its ability to specifically regulating the MAPK signaling pathway.
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