Papers on
histone acetyltransferase
Are epigenetic drugs for diabetes and obesity at our door step?Choudhury et al., Kingsville, United States. In Drug Discov Today, Jan 2016
These classes include histone deacetylase inhibitors (HDACi), histone acetyltransferase inhibitors (HATi), protein arginine methyltransferase inhibitors (PRMTis), DNA methyltransferase inhibitors (DNMTis), histone demethylating inhibitors (HDMis), and sirtuin-activating compounds (STACs).
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.Joseph et al., Stockholm, Sweden. In Nature, 2013
Here we report that induction of autophagy is coupled to reduction of histone H4 lysine 16 acetylation (H4K16ac) through downregulation of the histone acetyltransferase hMOF (also called KAT8 or MYST1), and demonstrate that this histone modification regulates the outcome of autophagy.