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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Histatin 1

histidine-rich protein 2, histatin 1, histidine-rich protein II
Top mentioned proteins: HAD, INI1, CAN, ACID, OUT
Papers on histidine-rich protein 2
Genetic diversity of Plasmodium falciparum histidine-rich protein 2 in the China-Myanmar border area.
New
Fan et al., Dalian, China. In Acta Trop, Dec 2015
Deletion of the Plasmodium falciparum histidine-rich protein 2 (pfhrp2) gene may affect the performance of PfHRP2-based rapid diagnostic tests (RDTs).
Quality assessment and antiplasmodial activity of West African Cochlospermum species.
New
Novak et al., Vienna, Austria. In Phytochemistry, Nov 2015
Antimalarial activity of preparations from dried rhizomes (decoction) was tested against the chloroquine-sensitive Plasmodium strain 3D7 using the histidine-rich protein II (HRP2) drug susceptibility assay and compared with extract preparations using organic solvents of different polarity.
Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria.
New
Dondorp et al., Bangkok, Thailand. In J Infect Dis, Nov 2015
METHODS:  In a cohort of patients with falciparum malaria hospitalized in Chittagong, Bangladesh, bulk RCD was measured using a laser diffraction technique, and parasite biomass was estimated from plasma concentrations of Plasmodium falciparum histidine-rich protein 2 (PfHRP2).
[Comparative study of assay methods for in vitro antimalarial drug efficacy testing in Plasmodium falciparum].
New
Gao et al., In Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, Apr 2015
OBJECTIVE: To compare four assay methods of in vitro antimalarial drug efficacy testing, including WHO microtest, Plasmodial lactate dehydrogenase (pLDH), Histidine-rich protein II (HRP II) and SYBR Green I, so as to determine a stable, simple, rapid, and economic method for monitoring the drug sensitivity of malaria parasites and screening new antimalarial drugs.
Genetic variation of pfhrp2 in Plasmodium falciparum isolates from Yemen and the performance of HRP2-based malaria rapid diagnostic test.
Surin et al., Kuala Lumpur, Malaysia. In Parasit Vectors, 2014
BACKGROUND: The genetic variation in the Plasmodium falciparum histidine-rich protein 2 (pfhrp2) gene that may compromise the use of pfhrp2-based rapid diagnostic tests (RDTs) for the diagnosis of malaria was assessed in P. falciparum isolates from Yemen.
Deletion of Plasmodium falciparum Histidine-Rich Protein 2 (pfhrp2) and Histidine-Rich Protein 3 (pfhrp3) Genes in Colombian Parasites.
Barnwell et al., Cali, Colombia. In Plos One, 2014
However, some of the inconsistencies observed with results from Plasmodium falciparum histidine-rich protein 2 (PfHRP2)-based RDTs could also be explained by the deletion of the gene that encodes the protein, pfhrp2, and its structural homolog, pfhrp3, in some parasite isolates.
High prevalence of asymptomatic malaria infections: a cross-sectional study in rural areas in six departments in Haiti.
Dame et al., Gainesville, United States. In Malar J, 2014
METHODS: Three different methods of parasite detection were compared to assess their utility in approximating the prevalence of P. falciparum infections in the population: malaria rapid diagnostic test (RDT) designed to detect histidine-rich protein 2 (HRP2), thick smear microscopy, and a quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay based upon the small sub-unit ribosomal RNA.
In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.
Pohlit et al., Manaus, Brazil. In Malar J, 2014
Median inhibitory concentrations (IC50) were established against chloroquine-resistant P. falciparum W2 clone using monoclonal anti-HRPII (histidine-rich protein II) antibodies in an enzyme-linked immunosorbent assay.
Potential biomarkers and their applications for rapid and reliable detection of malaria.
Review
Goswami et al., Guwāhāti, India. In Biomed Res Int, 2013
Among the various biomarkers, plasmodial lactate dehydrogenase and histidine-rich protein II (HRP II) have received increasing attention for developing rapid and reliable detection techniques for malaria.
Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting.
Review
Cunningham et al., Genève, Switzerland. In Malar J, 2013
Malaria rapid diagnostic tests (RDTs) play a critical role in malaria case management, surveillance and case investigations.
Malaria rapid diagnostic tests: challenges and prospects.
Review
Goldring et al., Pietermaritzburg, South Africa. In J Med Microbiol, 2013
Three antigens - Plasmodium falciparum histidine-rich protein 2 (PfHRP2), plasmodial aldolase and plasmodial lactate dehydrogenase (pLDH) - are currently used for RDTs.
Salivary peptidomics.
Review
Vitorino et al., Aveiro, Portugal. In Expert Rev Proteomics, 2010
Gln-Gly cleavages are largely associated with PRP classes, while Tyr-Gly cleavages are related to histatin 1 and to the P-B peptide.
Transcriptional regulation of the salivary histatin gene: finding of a strong positive regulatory element and its binding protein.
GeneRIF
Wang et al., Matsumoto, Japan. In J Biochem, 2009
These findings indicate that the regulation of the histatin gene expression may be intricate, and it seems to have a cell-type preference in the salivary gland cells.
Testing of natural products and synthetic molecules aiming at new antimalarials.
Review
Krettli et al., Belo Horizonte, Brazil. In Curr Drug Targets, 2009
Other methodologies have proven to be more precise and allow mass screening of new compounds against PF blood stages, such as: (i) measuring the incorporation of radioactive hypoxanthine by the parasites; (ii) indirect colorimetric assays in which specific parasite enzyme activities, and histidine-rich protein II (HRP2) production are measured with the help of monoclonal antibodies; (iii) the beta-haematin formation, and; (iv) assays using green fluorescent protein (GFP) in gene-expressing parasites.
Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.
GeneRIF
Veerman et al., Amsterdam, Netherlands. In Faseb J, 2008
histatin 1 (Hst1) and histatin 2 (Hst2) as major wound-closing factors in human saliva
Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.
GeneRIF
Messana et al., Cagliari, Italy. In J Proteome Res, 2007
The results allowed locating sulfation on the last four tyrosines (Tyr 27, 30, 34, and 36).
Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.
GeneRIF
Watanabe et al., Okayama, Japan. In Calcif Tissue Int, 2002
inhibits calcium phosphate precipitation
Plasmodium hemozoin formation mediated by histidine-rich proteins.
Impact
Goldberg et al., Saint Louis, United States. In Science, 1996
Antibodies identified histidine-rich protein II (HRP II) in purified digestive vacuoles.
Diagnosis of malaria by detection of Plasmodium falciparum HRP-2 antigen with a rapid dipstick antigen-capture assay.
Impact
Hoffman et al., Rockville, United States. In Lancet, 1994
Two field studies in Kenya and an experimental challenge study in the USA were done to assess the accuracy of a dipstick antigen-capture assay based on qualitative detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP-2) in peripheral blood for diagnosis of P falciparum infection.
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