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Histidine decarboxylase

histidine decarboxylase
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: ACID, MAST, Gastrin, CAN, HAD
Papers on histidine decarboxylase
Development of molecular approach based on PCR assay for detection of histamine producing bacteria.
Chomnawang et al., Bangkok, Thailand. In J Food Sci Technol, Jan 2016
PCR method was developed to target the histidine decarboxylase gene (hdc).
Phenotypic variability in human skin mast cells.
Zuberbier et al., Berlin, Germany. In Exp Dermatol, Jan 2016
Pathophysiologically relevant key features were quantified and correlated: transcripts of c-kit, FcεRIα, FcεRIβ, FcεRIγ, histidine decarboxylase, tryptase, and chymase; surface expression of c-Kit, FcεRIα; activity of tryptase, and chymase; histamine content and release triggered by FcεRI and Ca(2+) ionophore.
Role of Histamine H1-receptor on Behavioral States and Wake Maintenance during Deficiency of a Brain Activating System: a Study using a Knockout Mouse Model.
Lin et al., Lyon, France. In Neuropharmacology, Jan 2016
UNASSIGNED: Using knockout (KO) mice lacking the histamine (HA)-synthetizing enzyme (histidine decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in maintaining wakefulness (W) under behavioral challenges.
Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours.
Janson et al., Uppsala, Sweden. In World J Gastroenterol, Jan 2016
AIM: To study histidine decarboxylase (HDC) expression in normal and neoplastic gastric neuroendocrine cells in relationship to the main histamine metabolite.
Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri.
Versalovic et al., Houston, United States. In Mbio, 2014
Only strains that possess the hdc gene cluster, including the histidine decarboxylase and histidine-histamine antiporter genes, can suppress colitis and mucosal cytokine (interleukin-6 [IL-6] and IL-1β in the colon) gene expression.
Histamine H4 receptor: insights into a potential therapeutic target in breast cancer.
Medina et al., Junín, Argentina. In Front Biosci (schol Ed), 2014
Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production.
Modulation of behavior by the histaminergic system: lessons from HDC-, H3R- and H4R-deficient mice.
Seifert et al., Hannover, Germany. In Neurosci Biobehav Rev, 2014
Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate the immune system, but is also acting as a neurotransmitter.
Analysis of histamine receptor knockout mice in models of inflammation.
Seifert et al., Hannover, Germany. In J Pharmacol Exp Ther, 2014
Here, we summarize data obtained with histamine-deficient L-histidine decarboxylase knockout and histamine receptor subtype knockout mice in inflammation models.
Biochemical, Biomedical and Metabolic Aspects of Imidazole-Containing Dipeptides with the Inherent Complexity to Neurodegenerative Diseases and Various States of Mental Well-Being: A Challenging Correction and Neurotherapeutic Pharmaceutical Biotechnology for Treating Cognitive Deficits, Depression and Intellectual Disabilities.
Babizhayev, Moscow, Russia. In Curr Pharm Biotechnol, 2013
A tissue carnosine-degrading enzyme (CN2) colocalized with the activity of histidine decarboxylase to histamine neurons in the hypothalamic tuberomammillary nucleus (TMN) plays a key role in the neuro-transmission and neuroregulation roles of imidazole-containing based dipeptides.
Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings.
Francis et al., Temple, United States. In Hepatobiliary Surg Nutr, 2013
In this review, we have highlighted the role that histamine, histidine decarboxylase (HDC), histamine receptors and mast cells (the main source of histamine in the body) play during both pancreatitis and pancreatic cancer.
Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase.
Higuchi et al., Akō, Japan. In J Biol Chem, 2012
Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase.
Purification, crystallization and preliminary X-ray analysis of human histidine decarboxylase.
Higuchi et al., Akō, Japan. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees
Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.
Alpini et al., Temple, United States. In Gut, 2012
The novel concept that an autocrine loop, consisting of enhanced histamine synthesis by histidine decarboxylase, sustains cholangiocarcinoma growth is proposed.
Mutation screening of the HDC gene in Chinese Han patients with Tourette syndrome.
Deng et al., Changsha, China. In Am J Med Genet B Neuropsychiatr Genet, 2012
Variants in the HDC gene may play little or no role in Tourette Syndrome susceptibility in Chinese Han population.
Histidine decarboxylase is identified as a potential biomarker of intestinal mucosal injury in patients with acute intestinal obstruction.
Qin et al., Shanghai, China. In Mol Med, 2010
It was shown that for serum and urine, HDC levels achieved sensitivities and specificities compatible to or even greater than those of established biomarkers for the diagnosis of intestinal mucosal injury in patients with acute intestinal obstruction.
L-histidine decarboxylase and Tourette's syndrome.
State et al., New Haven, United States. In N Engl J Med, 2010
identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis which points to its role in Tourette's syndrome and tics
Gastric endocrine cells: gene expression, processing, and targeting of active products.
Dimaline et al., Liverpool, United Kingdom. In Physiol Rev, 1996
Recent work indicates physiological regulation of the expression of genes encoding cytosolic enzymes such as histidine decarboxylase, which converts histidine to histamine, and of secretory granule transporters such as vesicular monoamine transporter type 2, which concentrates amines in secretory vesicles.
Brain histamine: rapid apparent turnover altered by restraint and cold stress.
Snyder et al., In Science, 1971
Histamine content of rat brain was lowered quickly by inhibitors of histidine decarboxylase, suggesting that a portion of brain histamine turns over rapidly.
Histamine synthesis and gastric secretion after portacaval shunt.
Snyder et al., In Science, 1965
This appears to be secondary to increased activity of the histamine-synthesizing enzyme, histidine decarboxylase.
Relationship of stress-induced histidine decarboxylase to circulatory homeostasis and shock.
SCHAYER, In Science, 1960
Histidine decarboxylase activity of mouse tissues is increased by stress and by injection of epinephrine and norepinephrine, suggesting a balance between histamine and catechol amines producing a component of circulatory homeostasis.
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