gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Histamine N-methyltransferase

Histamine N-Methyltransferase, HMT, HNMT, H2-M3
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Histone, HAD, ACID, MHC
Papers using Histamine N-Methyltransferase antibodies
Gitools: analysis and visualisation of genomic data using interactive heat-maps.
Supplier
Blagosklonny Mikhail V., In PLoS ONE, 2010
... Pearson's correlation coefficient (PCC) of HDM and HMT expression profiles in normal tissues and cancer cell lines was analyzed using Gitools.We used the TissueScan Cancer Survey Tissue qPCR panel 384-1 (OriGene, Cat# CSRT102), which contains ...
A conducting salt-based amperometric biosensor for measurement of extracellular lactate accumulation in ischemic myocardium
Supplier
Willander Magnus et al., In Sensors (Basel, Switzerland), 1996
... O], hexamethylenetetramine (HMT), d-glucose, l-glucose-fructose were purchased from Sigma Aldrich (Sweden) ...
Papers on Histamine N-Methyltransferase
Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney.
New
De Marinis et al., Malmö, Sweden. In Biochem Biophys Res Commun, Feb 2016
Further proof for the involvement of histone acetylation and methylation in glucose-induced changes in OPN gene expression was obtained by manipulating histone modifications thereby OPN gene expression by histone deacetylase (HDAC) inhibitor trichostatin A and histone methyltransferase (HMT) inhibitor MM-102.
Identification and characterization of transcriptional control region of the human beta 1,4-mannosyltransferase gene.
New
Gao et al., Hiratsuka, Japan. In Cytotechnology, Dec 2015
We have previously reported cloning and identification of the human gene, HMT-1, which encodes chitobiosyldiphosphodolichol beta-mannosyltransferase (β1,4-MT) involved in the early assembly of DLO.
Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.
New
Bruner et al., Gainesville, United States. In Biochem J, Dec 2015
The mmuM gene product from Escherichia coli is an archetypal HMT family protein and contains a predicted Zn-binding motif in the enzyme active site.
Epigenetic therapy of myelodysplastic syndromes and acute myeloid leukemia.
Review
New
Fianchi et al., Roma, Italy. In Curr Opin Oncol, Nov 2015
PURPOSE OF REVIEW: This review will discuss issues arising along with the expanding use of hypomethylating treatment (HMT) in the management of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS).
Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity.
Review
New
Simeonov et al., Rockville, United States. In Drug Discov Today Technol, Nov 2015
The evident need for complementary cellular approaches has recently propelled the development of cell-based assays that enable screening of HMT and HDM enzymes in a more relevant environment.
Effects of high levels of dietary zinc oxide on ex vivo epithelial histamine response and investigations on histamine receptor action in the proximal colon of weaned piglets.
New
Zentek et al., In J Anim Sci, Nov 2015
Tissue was pretreated with or without aminoguanidine and amodiaquine to block the histamine-degrading enzymes diamine oxidase (DAO) and histamine -methyltransferase (HMT), respectively.
[Development of novel epigenetic molecular-targeting agents].
Review
New
Sakai et al., In Nihon Rinsho, Aug 2015
Moreover, histone methyltransferase(HMT) inhibitors and histone demethylase(HDM) inhibitors have been also discovered and some agents are in clinical trials.
Still Heart Encodes a Structural HMT, SMYD1b, with Chaperone-Like Function during Fast Muscle Sarcomere Assembly.
Pilgrim et al., Edmonton, Canada. In Plos One, 2014
The vertebrate sarcomere is a complex and highly organized contractile structure whose assembly and function requires the coordination of hundreds of proteins.
Cancer drug discovery targeting histone methyltransferases: an update.
Review
Li et al., North Chicago, United States. In Curr Med Chem, 2014
Histone methyl transferases (HMTs) are an important component in epigenome and HMT inhibitors are being pursued intensely by both pharmaceutical industry and academic institutions.
Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease.
Review
Rogers et al., Cleveland, United States. In Blood Res, 2014
All patients will eventually lose their response to therapy, and the survival outcome of MDS patients is poor (median survival of 4.5 months) especially for patients who fail (refractory/relapsed) HMT.
Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.
Impact
Smyth et al., Melbourne, Australia. In Nat Immunol, 2012
Here we found that the prototypic inhibitory receptor Ly49A bound the highly conserved nonclassical MHC class I molecule H2-M3 with an affinity similar to its affinity for H-2D(d).
Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism.
Impact
Wu et al., Hong Kong, Hong Kong. In Cell Stem Cell, 2012
Pax3/7BP is a ubiquitously expressed nuclear protein, enriched in Pax7+ muscle precursor cells (MPCs), and serves as an indispensable adaptor for Pax7 to recruit the histone 3 lysine 4 (H3K4) methyltransferase (HMT) complex by bridging Pax7 and Wdr5.
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.
GeneRIF
Krainc et al., Split, Croatia. In Neurobiol Aging, 2012
The results of this study indicated that Histamine N-methyltransferase Thr105Ile polymorphism is associated Parkinson's disease.
No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
GeneRIF
Terzić et al., Split, Croatia. In Neurosci Lett, 2011
Lack of the association of HNMT Thr105Ile functional polymorphism with Alzheimer's disease is found.
Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3.
GeneRIF
Wang et al., Chicago, United States. In J Immunol, 2011
Similar to H2-M3-restricted CD8-positive T cells, CD8+ T cells restricted to other major histocompatibility class Ib molecules are able to undergo extensive proliferation after primary infection with Listeria monocytogenes.
Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis.
GeneRIF
Jiménez-Jiménez et al., Badajoz, Spain. In Eur J Neurol, 2010
our results suggest that, despite the possible role of histamine in the inflammatory processes related with the pathogenesis of MS, HNMT polymorphism is not related with the risk for MS in Caucasian Spanish people
Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.
GeneRIF
Farrer et al., Jacksonville, United States. In Parkinsonism Relat Disord, 2010
This study do not support the HNMT Thr105Ile variant as a factor in disease development or a genetic link between the disorders.
Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex.
Impact
Rudnicki et al., Ottawa, Canada. In Nat Cell Biol, 2008
This revealed that Pax7 associates with the Wdr5-Ash2L-MLL2 histone methyltransferase (HMT) complex that directs methylation of histone H3 lysine 4 (H3K4, refs 4-10).
Patterns of nonclassical MHC antigen presentation.
Impact
Fremont et al., Saint Louis, United States. In Nat Immunol, 2007
For certain nonclassical 'MHC-like' class Ib proteins, such as H2-M3 and CD1d, their respective binding grooves seem to have been adapted to present to T cells unique molecular patterns analogous to those involved in innate signaling.
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors.
Impact
Rosenfeld et al., San Diego, United States. In Cell, 2007
This strategy, based at least in part on an HMT-dependent inhibitory histone code, imposes a requirement for specific histone demethylases, including LSD1, to permit ligand- and signal-dependent activation of regulated gene expression.
share on facebooktweetadd +1mail to friends