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Histamine N-Methyltransferase, HMT, HNMT, H2-M3
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] (from
... Pearson's correlation coefficient (PCC) of HDM and HMT expression profiles in normal tissues and cancer cell lines was analyzed using Gitools.We used the TissueScan Cancer Survey Tissue qPCR panel 384-1 (OriGene, Cat# CSRT102), which contains ...
Wang et al., Chicago, United States. In J Immunol, 2011
Similar to H2-M3-restricted CD8-positive T cells, CD8+ T cells restricted to other major histocompatibility class Ib molecules are able to undergo extensive proliferation after primary infection with Listeria monocytogenes.
Jiménez-Jiménez et al., Badajoz, Spain. In Eur J Neurol, 2010
our results suggest that, despite the possible role of histamine in the inflammatory processes related with the pathogenesis of MS, HNMT polymorphism is not related with the risk for MS in Caucasian Spanish people