histamine H3 receptor
Lipopolysaccharide and histaminergic systems interact to mediate food intake in broilers.
Tehrān, Iran. In Br Poult Sci, Oct 2015
The effects of intracerebroventricular (ICV) injection of α-fluoromethylhistidine (α-FMH, histidine decarboxylase inhibitor), chlorpheniramine (histamine H1 receptor antagonist), famotidine (histamine H2 receptor antagonist) and thioperamide (histamine H3 receptor antagonist) on lipopolysaccharide (LPS)-induced hypophagia in broilers were studied.
3-(1'-Cyclobutylspiro[4H-1,3-benzodioxine-2,4'-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist.
West Chester, United States. In Neuropharmacology, Oct 2015
UNASSIGNED: CEP-32215 is a new, potent, selective, and orally bioavailable inverse agonist of the histamine H3 receptor (H3R) with drug-like properties.
The Effect of Subchronic Dosing of Ciproxifan and Clobenpropit on Dopamine and Histamine Levels in Rats.
New Delhi, India. In J Exp Neurosci, 2014
The present study was designed to investigate the effect of once daily for 7-day (subchronic treatment) dosing of histamine H3 receptor antagonists, ciproxifan (CPX) (3 mg/kg, i.p.), and clobenpropit (CBP) (15 mg/kg, i.p), including clozapine (CLZ) (3.0 mg/kg, i.p.) and chlorpromazine (CPZ) (3.0 mg/kg, i.p.), the atypical and typical antipsychotic, respectively, on MK-801(0.2
Where do we stand in the field of anti-abuse drug discovery?
Aachen, Germany. In Expert Opin Drug Discov, 2014
It is hoped that at least a few of the investigated approaches (e.g., various glutamate and GABA receptor modulators, nociceptin/orphanin FQ peptide receptor agonists, or histamine H3 receptor antagonists) reach the stage of clinical development and eventually reach regulatory approval.
Emerging drugs for neuropathic pain.
Kingston, Canada. In Expert Opin Emerg Drugs, 2014
These include calcium channel antagonists, vanilloid receptor antagonists, potassium channel agonists, NMDA antagonists, novel opioid receptor agonists, histamine H3 receptor antagonists, a novel sodium channel antagonist, serotonin modulators, a novel acetylcholine receptor agonist, α-2b adrenoreceptor agonist, cannabinoid CB2 receptor agonist, nitric oxide synthase inhibitor, orexin receptor antagonist, angiotensin II 2 antagonist, imidazoline I2 receptor agonist, apoptosis inhibitor and fatty acid amide hydrolase inhibitor.
The other side of the histamine H3 receptor.
Wellington, New Zealand. In Trends Neurosci, 2014
Although histamine H3 receptors are predominantly known as presynaptic receptors, regulating the release of neurotransmitters such as dopamine, acetylcholine, and histamine, in the striatal complex the vast majority of these receptors are actually located on the other side, in other words postsynaptically.
The histamine H3 receptor and eating behavior.
Florence, Italy. In J Pharmacol Exp Ther, 2011
This review outlines the relevance of the histaminergic system in controlling feeding behavior and evaluates the potential role of the histamine H3 receptor as a target for regulating obesity.
The histamine H3 receptor: from gene cloning to H3 receptor drugs.
Amsterdam, Netherlands. In Nat Rev Drug Discov, 2005
"The human H(3)receptor gene suggested to consist of either 3 exons and 2 introns, or 4 exons and 3 introns, with ...additional exon accounting for...8 additional carboxy(C)-terminal amino acids...in some human H(3) receptor sequences"