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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Histamine receptor H2

histamine H2 receptor, H2R
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: ACID, H1, HAD, V1a, CAN
Papers on histamine H2 receptor
Ranitidine-Induced Anaphylaxis: Clinical Features, Cross-Reactivity, and Skin Testing.
New
Park et al., Seoul, South Korea. In Clin Exp Allergy, Feb 2016
BACKGROUND: Histamine H2 receptor antagonists are commonly prescribed medications and are known to be well tolerated.
Cellular analysis of the histamine H4 receptor in human myeloid cells.
New
Kahnt et al., Frankfurt am Main, Germany. In Biochem Pharmacol, Feb 2016
This was put into context with the expression of the H1R and H2R.
Spinal histamine in attenuation of mechanical hypersensitivity in the spinal nerve ligation-induced model of experimental neuropathy.
New
Pertovaara et al., Helsinki, Finland. In Eur J Pharmacol, Jan 2016
Histamine-induced mechanical antihypersensitivity effect was prevented by spinal pretreatment with zolantidine (histamine H2 receptor antagonist), prazosine (α1-adrenoceptor antagonist) and bicuculline (γ-aminobutyric acid subtype A, GABAA, receptor antagonist), but not by pyrilamine (histamine H1 receptor antagonist), atipamezole (α2-adrenoceptor antagonist), or raclopride (dopamine D2 receptor antagonist).
Protective effect of histamine microinjected into cerebellar fastigial nucleus on stress gastric mucosal damage in rats.
New
Zhang et al., Xuzhou, China. In Brain Res, Jan 2016
We found that the microinjection of histamine (0.05, 0.5, and 5μg) into FN significantly attenuated the SGMD, in a dose-dependent manner, whereas, the microinjection of histamine H2 receptor antagonist, ranitidine, and glutamic acid decarboxylase antagonist, 3-mercaptopropionic acid (3-MPA) exacerbated the SGMD.
Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats.
New
Kieć-Kononowiczc et al., Al `Ayn, United Arab Emirates. In Neuropharmacology, Nov 2015
Interestingly, the procognitive effect of DL77 on retrieval was completely abrogated when rats were pretreated with the centrally-acting H2R antagonist zolantidine (ZOL) but not the centrally acting H1R antagonist PYR, indicating that histaminergic pathways through activation of H2Rs appear to be participating in neuronal circuits involved in retrieval processes.
High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor.
New
Seifert et al., Hannover, Germany. In Naunyn Schmiedebergs Arch Pharmacol, Nov 2015
Its antileukemic activity is related to histamine H2-receptor (H2R)-mediated inhibition of reactive oxygen species (ROS) production in myeloid cells facilitating survival of antineoplastic lymphocytes.
Diagnosis and Treatment of Gastroesophageal Reflux in Infants and Children.
New
Karmes et al., United States. In Am Fam Physician, Nov 2015
Histamine H2 receptor antagonists and proton pump inhibitors are the principal medical therapies for GERD.
Refractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management.
Review
New
Qiu et al., Shanghai, China. In World J Methodol, Oct 2015
The strategies of pharmacological treatment for refractory chronic cough due to reflux include the optimization of proton pump inhibitors and add-on therapies with histamine H2 receptor antagonists, baclofen and gabapentin.
Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.
Review
New
Mimouni et al., Tel Aviv-Yafo, Israel. In Br J Clin Pharmacol, Aug 2015
Adverse effects have been reported in at least 23% of patients treated with histamine H2 receptor antagonists (H2 RAs) and 34% of those treated with proton pump inhibitors (PPIs), and mostly include headaches, diarrhoea, nausea (H2 RAs and PPIs) and constipation (PPIs).
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.
Review
New
Impact
Haas et al., Helsinki, Finland. In Pharmacol Rev, Jul 2015
Its physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention.
Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri.
Versalovic et al., Houston, United States. In Mbio, 2014
The ability of probiotic L. reuteri to suppress colitis depends on the presence of a bacterial histidine decarboxylase gene(s) in the intestinal microbiome, consumption of a histidine-containing diet, and signaling via the histamine H2 receptor (H2R).
Protective effect of histamine microinjected into the cerebellar fastigial nucleus on stress-induced gastric mucosal damage in rats.
Liang et al., Xuzhou, China. In Am J Transl Res, 2014
RESULTS: We observed that histamine microinjection into the FN markedly attenuated SGMD in a dose-dependent manner, and was prevented by pre-treatment with the ranitidine (a selective histamine H2 receptor antagonist) into the FN.
Modulation of behavior by the histaminergic system: lessons from H(1)R-and H(2)R-deficient mice.
Review
Seifert et al., Hannover, Germany. In Neurosci Biobehav Rev, 2014
Central effects of H2R are similar, but only few behavioral results from knockout models are available.
Histamine receptors and antihistamines: from discovery to clinical applications.
Review
Marone et al., Napoli, Italy. In Chem Immunol Allergy, 2013
Using selective agonists and antagonists, as well as molecular biology tools, four histamine receptors (H1R, H2R, H3R and H4R) have been identified.
Association between common genetic variant of HRH2 and gastric cancer risk.
GeneRIF
Shibata et al., Kanazawa, Japan. In Int J Oncol, 2012
1018 GG homozygosity of HRH2 may be associated with the severity of gastric mucosal atrophy
Effects of -1018G>A polymorphism of HRH2 (rs2607474) on the severity of gastric mucosal atrophy.
GeneRIF
Arisawa et al., Kanazawa, Japan. In J Gastrointestin Liver Dis, 2012
The results suggest that HRH2 -1018 GG homozygote is a risk factor for the severity of gastric mucosal atrophy under the influence of H. pylori infection, especially in older subjects.
Histamine via the histamine H₂-receptor reduces α-CD3-induced interferon-γ synthesis in murine CD4+ T cells in an indirect manner.
GeneRIF
Neumann et al., Hannover, Germany. In J Interferon Cytokine Res, 2012
Histamine reduced the alpha-CD3-induced interferon-gamma (IFN-gamma) production of CD4+ cells via the histamine H-receptor.
Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.
GeneRIF
State et al., New Haven, United States. In Biol Psychiatry, 2012
evidence supports the involvement of histaminergic and gamma-aminobutyric acidergic mechanisms in the etiology of TS and show an overlap of rare CNVs in TS and autism spectrum disorder.
Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation.
GeneRIF
Neumann et al., Hannover, Germany. In Plos One, 2011
Data suggest that a combined pharmacological targeting of histamine H(1) and H(4) receptors could be taken into consideration as an option for the prevention of asthma and maybe other allergic diseases.
Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors.
Impact
Akdis et al., China. In Nature, 2001
Here we report that histamine enhances TH1-type responses by triggering the histamine receptor type 1 (H1R), whereas both TH1- and TH2-type responses are negatively regulated by H2R through the activation of different biochemical intracellular signals.
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