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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Histamine receptor H1

histamine H1 receptor, histamine H(1) receptor, H1R, hIR
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: H1, V1a, CAN, HAD, MAST
Papers on histamine H1 receptor
2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity.
Strasser et al., Erlangen, Germany. In Bioorg Med Chem Lett, Feb 2016
Distinct diaminopyrimidines, for example, 4-(4-methylpiperazin-1-yl)-5,6-dihydrobenzo[h]quinazolin-2-amine are histamine H4 receptor (H4R) antagonists and show high affinity to the H4R, but only a moderate affinity to the histamine H1 receptor (H1R).
Cellular analysis of the histamine H4 receptor in human myeloid cells.
Kahnt et al., Frankfurt am Main, Germany. In Biochem Pharmacol, Feb 2016
This was put into context with the expression of the H1R and H2R.
A new, rapid in vivo method to evaluate allergic responses through distinctive distribution of a fluorescent-labeled immune complex: Potential to investigate anti-allergic effects of compounds administered either systemically or topically to the skin.
Yoshino et al., Kōbe, Japan. In J Immunol Methods, Jan 2016
The parallel induction of hypothermia, scratching, serum histamine increases, and ASDIS as well as the inhibition of ASDIS by either the systemic administration of a histamine H1 receptor antagonist or mast cell-depleting antibody suggested that our method, which only required 15min, induced these allergic responses including ASDIS.
Spinal histamine in attenuation of mechanical hypersensitivity in the spinal nerve ligation-induced model of experimental neuropathy.
Pertovaara et al., Helsinki, Finland. In Eur J Pharmacol, Jan 2016
Histamine-induced mechanical antihypersensitivity effect was prevented by spinal pretreatment with zolantidine (histamine H2 receptor antagonist), prazosine (α1-adrenoceptor antagonist) and bicuculline (γ-aminobutyric acid subtype A, GABAA, receptor antagonist), but not by pyrilamine (histamine H1 receptor antagonist), atipamezole (α2-adrenoceptor antagonist), or raclopride (dopamine D2 receptor antagonist).
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.
Daley et al., Lafayette, United States. In Bioorg Med Chem Lett, Jan 2016
At α2A, α2B, and α2C receptors, and at the histamine H1 receptor, binding affinity was correlated with the Hammett substituent parameter σp; higher affinity was associated with larger σp values.
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.
Haas et al., Helsinki, Finland. In Pharmacol Rev, Jul 2015
Its physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention.
Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways.
Monczor et al., Buenos Aires, Argentina. In Sci Rep, 2014
Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma.
The role of histamine H1 and H4 receptors in atopic dermatitis: from basic research to clinical study.
Hirasawa et al., Japan. In Allergol Int, 2014
It has been shown to regulate the expression of pruritic factors, such as nerve growth factor and semaphorin 3A, in skin keratinocytes via histamine H1 receptor (H1R).
Cigarette Smoke Amplifies Inflammatory Response and Atherosclerosis Progression Through Activation of the H1R-TLR2/4-COX2 Axis.
Dileepan et al., Kansas City, United States. In Front Immunol, 2014
Emerging evidence suggests that infection and persistent inflammation are key players in the pathogenesis of atherosclerotic cardiovascular disease (CVD).
Modulation of behavior by the histaminergic system: lessons from H(1)R-and H(2)R-deficient mice.
Seifert et al., Hannover, Germany. In Neurosci Biobehav Rev, 2014
The H1R causes central side effects, e.g. of first generation antihistamines, antidepressants or antipsychotics and represents the component of the central histaminergic system most extensively studied in behavior experiments with knock-out mice.
Histamine receptors and antihistamines: from discovery to clinical applications.
Marone et al., Napoli, Italy. In Chem Immunol Allergy, 2013
Using selective agonists and antagonists, as well as molecular biology tools, four histamine receptors (H1R, H2R, H3R and H4R) have been identified.
Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.
State et al., New Haven, United States. In Biol Psychiatry, 2012
evidence supports the involvement of histaminergic and gamma-aminobutyric acidergic mechanisms in the etiology of TS and show an overlap of rare CNVs in TS and autism spectrum disorder.
Involvement of protein kinase Cdelta/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 (PARP-1) signaling pathway in histamine-induced up-regulation of histamine H1 receptor gene expression in HeLa cells.
Fukui et al., Tokushima, Japan. In J Biol Chem, 2011
the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway is involved in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells
Genetic predictors of antipsychotic-induced weight gain: a case-matched multi-gene study.
Chang et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011
The glu349asp polymorphism of histamine-1 receptor is not associated with antipsychotic induced weight gain.
Structure of the human histamine H1 receptor complex with doxepin.
Iwata et al., Kyoto, Japan. In Nature, 2011
crystal structure of the H(1)R complex with doxepin, a first-generation H(1)R antagonist
H1 and PAR2 receptors enhance delivery of immune-competent cells and molecules by interrupting E-cadherin adhesion in epithelia.
Winter et al., Iowa City, United States. In Trans Am Clin Climatol Assoc, 2010
H1 and PAR2 receptors enhance delivery of immune-competent cells and molecules by interrupting E-cadherin adhesion in lung epithelial cells.
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.
Dunford et al., San Diego, United States. In Nat Rev Drug Discov, 2008
The inflammatory responses resulting from the liberation of histamine have long been thought to be mediated by the histamine H1 receptor, and H1-receptor antagonists--commonly known as antihistamines--have been used to treat allergies for many years.
Identification of Bphs, an autoimmune disease locus, as histamine receptor H1.
Teuscher et al., Beijing, China. In Science, 2002
We report that congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice.
Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors.
Akdis et al., China. In Nature, 2001
Here we report that histamine enhances TH1-type responses by triggering the histamine receptor type 1 (H1R), whereas both TH1- and TH2-type responses are negatively regulated by H2R through the activation of different biochemical intracellular signals.
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