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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Huntingtin interacting protein 1 related

HIP1R, HIP1-related, HIP12, huntingtin interacting protein-1 related
Top mentioned proteins: Actin, huntingtin, MARS, HIP1, CAN
Papers on HIP1R
Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP.
New
Lawrie et al., Malaysia. In Exp Mol Pathol, Dec 2015
Huntingtin-interacting protein 1-related (HIP1R) is an endocytic protein involved in receptor trafficking, including regulating cell surface expression of receptor tyrosine kinases.
The single nucleotide polymorphism Rs12817488 is associated with Parkinson's disease in the Chinese population.
New
Tang et al., Changsha, China. In J Clin Neurosci, Jun 2015
A recent meta-analysis of datasets from five of the published Parkinson's disease (PD) genome-wide association studies implicated the single nucleotide polymorphism (SNP) rs12817488 in coiled-coil domain containing 62 (CCDC62)/huntingtin interacting protein 1 related (HIP1R) as a risk factor for PD.
Association analysis of STK39, MCCC1/LAMP3 and sporadic PD in the Chinese Han population.
Guo et al., Changsha, China. In Neurosci Lett, 2014
A meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe found 11 loci that surpassed the threshold for genome-wide significance (p<5×10(-8)), and five were newly identified loci (ACMSD, STK39, MCCC1/LAMP3, SYT11 and CCDC62/HIP1R).
Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients.
Banham et al., Oxford, United Kingdom. In Leukemia, 2014
We previously identified autoantibodies to the endocytic-associated protein Huntingtin-interacting protein 1-related (HIP1R) in diffuse large B-cell lymphoma (DLBCL) patients.
Spatiotemporal patterns of the Huntingtin-interacting protein 1-related gene in the mouse head.
Yaginuma et al., Tochigi, Japan. In Congenit Anom (kyoto), 2013
Huntingtin-interacting protein 1-related (Hip1r) was originally identified due to its homology to Huntingtin-interacting protein 1, which contributes to the development of Huntington's disease (HD).
Genetic association study between STK39 and CCDC62/HIP1R and Parkinson's disease.
Peng et al., Chengdu, China. In Plos One, 2012
BACKGROUND: The first large-scale meta-analysis of published genome-wide association studies (GWAS) in Parkinson's disease (PD) identified 5 new genetic loci (ACMSD, STK39, MCCC1/LAMP3, SYT11, and CCDC62/HIP1R).
GWAS risk factors in Parkinson's disease: LRRK2 coding variation and genetic interaction with PARK16.
Ross et al., Jacksonville, United States. In Am J Neurodegener Dis, 2012
BST1, SNCA, HLA-DRA, CCDC62/HIP1R and MAPT all showed a significant association with PD under different models of inheritance and LRRK2 showed a suggestive association.
Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease.
Review
Lauterbach, Macon, United States. In Prog Neuropsychopharmacol Biol Psychiatry, 2012
RESULTS: Psychotropic drugs can meaningfully affect PD risk gene mRNA transcription, including antipsychotics (upregulate dopamine receptors D2 and D3 (DRD2, DRD3); downregulate low-density lipoprotein receptor-related protein 8 (LRP8), ubiquitin carboxyl-terminal esterase L1 (UCHL1, also known as PARK5)), haloperidol (upregulates DRD3, parkin (PRKN, also known as PARK2), DRD2; downregulates brain-derived neurotrophic factor (BDNF)), risperidone (upregulates monoamine oxidase B (MAOB), DRD2), olanzapine (upregulates transmembrane protein 163 (TMEM163), BDNF, glutathione S-transferase mu 1 (GSTM1), MAOB, DRD2, solute carrier organic anion transporter family, member 3A1 (SLCO3A1)), aripiprazole (upregulates DRD2), quetiapine, paliperidone, lurasidone, carbamazepine, and many antidepressants (upregulate BDNF), lithium and bupropion (downregulate BDNF), amitriptyline (upregulates DRD3, DRD2), imipramine (upregulates BDNF, DRD3, DRD2), desipramine (upregulates BDNF, DRD3), and fluoxetine (upregulates acid beta-glucosidase (GBA), coiled-coil domain containing 62 (CCDC62), BDNF, DRD3, UCHL1, unc-13 homolog B (UNC13B), and perhaps huntingtin interacting protein 1 related (HIP1R); downregulates microtubule-associated protein tau (MAPT), methylcrotonoyl-coenzyme A carboxylase I (MCCC1), GSTM1, 28kDa calbindin 1 (CALB1)).
IFNγ contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice.
GeneRIF
Samuelson et al., Ann Arbor, United States. In Lab Invest, 2012
IFNgamma was required for the mucous cell hypertrophy and hyperplasia observed in Hip1r-deficient mice. IFNgamma is critical for the development of the gastric epithelial cell metaplasia that results from parietal cell atrophy in the Hip1r-deficient mice.
Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.
Impact
Kirchhausen et al., Boston, United States. In Nat Cell Biol, 2011
We also find that light-chain-bound Hip1R mediates actin engagement.
Genetics of Parkinson's disease and essential tremor.
Review
Zimprich, Vienna, Austria. In Curr Opin Neurol, 2011
RECENT FINDINGS: Within the last two years, genome-wide association (GWA) analyses have revealed a number of novel low-risk susceptibility variants for Parkinson's disease, among them HLA-DRB5, BST1, ACMSD, STK39, MCCC1/LAMP3, SYT11, and CCDC62/HIP1R) and have confirmed LINGO1 as risk factor for essential tremor.
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
Impact
Wood et al., In Lancet, 2011
Six were previously identified loci (MAPT, SNCA, HLA-DRB5, BST1, GAK and LRRK2) and five were newly identified loci (ACMSD, STK39, MCCC1/LAMP3, SYT11, and CCDC62/HIP1R).
Cytodifferentiation of the postnatal mouse stomach in normal and Huntingtin-interacting protein 1-related-deficient mice.
GeneRIF
Samuelson et al., Ann Arbor, United States. In Am J Physiol Gastrointest Liver Physiol, 2010
This study characterized gastric gland development in wild-type and Hip1r-deficient mice to define normal development, as well as the timing and sequence of the cellular transformation events in the mutant stomach.
Huntingtin-interacting protein 1-related is required for accurate congression and segregation of chromosomes.
GeneRIF
Park, Pusan, South Korea. In Bmb Rep, 2010
HIP1r plays an important role in regulating the attachment of spindle microtubules to chromosomes during mitosis, an event that is required for accurate congression and segregation of chromosomes.
The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?
Review
Ashery et al., Tel Aviv-Yafo, Israel. In Biochem Soc Trans, 2010
HIP1 (huntingtin interacting protein 1) has two close relatives: HIP1R (HIP1-related) and yeast Sla2p.
HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death.
GeneRIF
Bae et al., South Korea. In Cell Physiol Biochem, 2008
This study provided the previously unknown function of HIP1R involved in the intrinsic cell death pathway and further explored possible mechanisms by which HIP1R induces cell death.
Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.
GeneRIF
Brodsky et al., San Francisco, United States. In J Biol Chem, 2008
Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain
Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: implications for oligodendrocyte viability.
Review
Carter, In Neurochem Int, 2007
Various other protein products of genes associated with bipolar disorder either bind to or are affected by phosphatidyl-inositol phosphate products of this pathway (ADBRK2, HIP1R, KCNQ2, RGS4, WFS1), are associated with its constituent elements (BCR, DUSP6, FAT, GNAZ) or are downstream targets of this signalling cascade (DPYSL2, DRD3, GAD1, G6PD, GCH1, KCNQ2, NOS3, SLC6A3, SLC6A4, SST, TH, TIMELESS).
Endocytosis and the cytoskeleton.
Review
Kessels et al., Magdeburg, Germany. In Int Rev Cytol, 2001
With molecules such as dynamin, syndapin, HIP1R, Abp1, synaptojanin, N-WASP, intersectin, and cortactin a set of molecular links is now available and it is likely that their further characterization will reveal the basic principles of a functional interconnection between the membrane cytoskeleton and the vesicle-budding machinery.
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.
Impact
Takenawa et al., Tokyo, Japan. In Science, 2001
Endocytic proteins such as epsin, AP180, and Hip1R (Sla2p) share a conserved modular region termed the epsin NH2-terminal homology (ENTH) domain, which plays a crucial role in clathrin-mediated endocytosis through an unknown target.
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