Aberrant palmitoylation in Huntington disease.
Vancouver, Canada. In Biochem Soc Trans, Apr 2015
In the presence of the HD mutation, the interactions between huntingtin (HTT) and huntingtin interacting protein 14 (HIP14 or DHHC17) and HIP14-like (DHHC13, a HIP14 orthologue), palmitoyl acyltransferases for HTT, are disturbed, resulting in reduced palmitoylation of HTT.
Memory and synaptic deficits in Hip14/DHHC17 knockout mice.
Vancouver, Canada. In Proc Natl Acad Sci U S A, 2014
Here we describe that the constitutive loss of huntingtin interacting protein 14 (Hip14, also known as DHHC17), a single member of the broad palmitoyl acyltransferase (PAT) family, produces marked alterations in synaptic function in varied brain regions and significantly impairs hippocampal memory and synaptic plasticity.
Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases.
Vancouver, Canada. In Prog Neurobiol, 2012
In total six PATs (HIP14, HIP14L, ZDHHC8, ZDHHC9, ZDHHC12, and ZDHHC15) and one thioesterase (PPT1) have been implicated in Huntington disease (HD), Alzheimer disease, schizophrenia, mental retardation, and infantile and adult onset forms of neuronal ceroid lipofuscinosis.
Insight into renal Mg2+ transporters.
Nijmegen, Netherlands. In Curr Opin Nephrol Hypertens, 2011
In addition to the well known transient receptor potential channel melastatin (TRPM), members 6 and 7, and the mitochondrial transporter Mrs2, additional Mg-transporting protein families can be acknowledged including the magnesium (Mag) transporters, the solute carrier (SLC) family 41 members, ancient conserved domain proteins (ACDP), nonimprinted in Prader-Willi/Angelman syndrome (NIPA) proteins, membrane Mg transporters (MMgT) and huntingtin-interacting protein 14 (HIP14).
Molecular identification of ancient and modern mammalian magnesium transporters.
Vancouver, Canada. In Am J Physiol Cell Physiol, 2010
However, other newly identified mammalian transporters, including TRPM6/7, MagT, NIPA, MMgT, and HIP14 families, are not represented in prokaryotic genomes, suggesting more recent development.