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Histidine triad nucleotide binding protein 2

Hint2, histidine triad nucleotide binding protein 2
Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: fibrillin-1, FHIT, CAN, HAD, SET
Papers on Hint2
Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide binding (Hint2) mitochondrial protein.
St-Pierre et al., Bern, Switzerland. In Am J Physiol Gastrointest Liver Physiol, Feb 2016
UNASSIGNED: The histidine nucleotide binding protein, Hint2, is a mitochondrial phosphoramidase expressed in liver, brown fat, pancreas and muscle.
Novel reactivity of Fhit proteins: catalysts for fluorolysis of nucleoside 5'-phosphoramidates and nucleoside 5'-phosphosulfates to generate nucleoside 5'-phosphorofluoridates.
Guranowski et al., Poznań, Poland. In Biochem J, Jul 2015
Among other HIT proteins, human histidine triad nucleotide-binding protein (Hint1) catalysed fluorolysis of NH2-pA 20 times and human Hint2 40 times more slowly than human Fhit.
Targeted deep DNA methylation analysis of circulating cell-free DNA in plasma using massively parallel semiconductor sequencing.
Holmila et al., Lyon, France. In Epigenomics, 2014
MATERIALS & METHODS: Methylation of VIM, FBLN1, LTBP2, HINT2, h19 and IGF2 was analyzed in plasma cfDNA and white blood cell DNA obtained from eight hepatocellular carcinoma patients and eight controls using Ion Torrent™ PGM sequencer.
Genome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds.
Du et al., Beijing, China. In Bmc Genomics, 2014
One region was in OAR2 including three genes (NPR2, SPAG8 and HINT2) the influence growth traits.
Characterization of the effect of the mitochondrial protein Hint2 on intracellular Ca(2+) dynamics.
Dupont et al., Orsay, France. In Biophys J, 2013
Hint2, one of the five members of the superfamily of the histidine triad AMP-lysine hydrolase proteins, is expressed in mitochondria of various cell types.
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human histidine triad nucleotide-binding protein 2 (hHINT2).
Nawrot et al., Łódź, Poland. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013
Histidine triad nucleotide-binding protein 2 (HINT2) is a mitochondrial adenosine phosphoramidase mainly expressed in the pancreas, liver and adrenal gland.
Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.
Syed et al., Bethesda, United States. In Cancer Prev Res (phila), 2013
Four proteins were then selected for validation studies: histone H1.4 (HIST1H1E), histidine triad nucleotide-binding protein 2 (HINT2), IFN-induced, double-stranded RNA-activated protein kinase (EIF2AK2), and Bcl-2-associated X protein (BAX).
Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.
St-Pierre et al., Bern, Switzerland. In Hepatology, 2013
UNLABELLED: The histidine triad nucleotide-binding (HINT2) protein is a mitochondrial adenosine phosphoramidase expressed in the liver and pancreas.
Hint2, the mitochondrial nucleoside 5'-phosphoramidate hydrolase; properties of the homogeneous protein from sheep (Ovis aries) liver.
Guranowski et al., Poznań, Poland. In Acta Biochim Pol, 2012
Our study focuses on the Hint2 protein purified by a simple procedure to homogeneity from sheep liver mitochondrial fraction (OaHint2).
Stable isotope metabolic labeling with a novel N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies.
Hambsch et al., München, Germany. In Plos One, 2008
Tissue from (15)N-labeled vs. (14)N-unlabeled mice was examined by mass spectrometry and differences in the expression of glyoxalase-1 (GLO1) and histidine triad nucleotide binding protein 2 (Hint2) proteins were correlated with the animals' psychopathological behaviors for methodological validation and proof of concept, respectively.
Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish.
Levenson et al., State College, United States. In Bmc Neurosci, 2008
A second set of NBPs, consisting of Pink1, Hint2, and Slc25a25, are destined for localization in mitochondria.
Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis.
Rossier et al., Genève, Switzerland. In Endocrinology, 2008
Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria.
Beta-catenin takes a HIT.
Weiske et al., Berlin, Germany. In Cell Cycle, 2008
To some of the family members including Fhit, Hint1 and Hint2, a tumor suppressive activity was assigned.
Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma.
Dufour et al., Bern, Switzerland. In Gastroenterology, 2006
Here we report the characterization of human Hint2.
Identification of proteins undergoing glutathionylation in oxidatively stressed hepatocytes and hepatoma cells.
Ghezzi et al., Milano, Italy. In Proteomics, 2003
Among the identified proteins some are the same or belong to the same functional class as those we have already identified in a previous paper on T cell blasts (actin, nucleophosmin, phosphogluconolactonase, myosin, profilin, cyclophilin A, stress 70 protein, ubiquitin in HepG2 cells and actin, peroxiredoxin 5, cytochrome C oxidase, heat shock cognate 70 in hepatocytes) while others are newly recognized (Ran specific GTPase activating protein, histidine triad nucleotide binding protein 2 in HepG2 cells and enoyl CoA hydratase in hepatocytes).
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