HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT.
Beijing, China. In Plos One, 2014
Recent studies suggest that epigenetic modifications, especially DNA methylation, could contribute to explain part of the missing heritability, and two epigenetic genome-wide analysis studies (EWAS) have reported that Hypoxia Inducible Factor 3 Alpha Subunit (HIF3A) methylation was associated with BMI or BMI change.
[Metastasis and hypoxia-inducible factor].
Japan. In Gan To Kagaku Ryoho, 2010
HIFs consist of a constitutively expressed subunit of HIF-1beta and an oxygen-regulated subunit of HIF-1alpha (or HIF-2alpha and HIF-3alpha).
Hypoxia and hypoxia-inducible factor in renal disease.
Tokyo, Japan. In Nephron Exp Nephrol, 2007
Intracellular accumulation of HIF induces the coordinated expression of a number of adaptive genes against hypoxic insult.Three isoforms of HIF-alpha subunits have been identified, HIF-1alpha, HIF-2alpha, and HIF-3alpha, of which HIF-2alpha is involved in the regulation of erythropoietin as well as oxidative stress.
Hypoxia and the HIF system in kidney disease.
Tokyo, Japan. In J Mol Med (berl), 2007
HIF consists of a constitutive beta-subunit and one of alternative oxygen-regulated HIF alpha-subunits (HIF-1alpha, HIF-2alpha, and HIF-3alpha), and HIF-2alpha is responsible for erythropoietin production.
Discovery of cancer biomarkers through the use of mouse models.
Ann Arbor, United States. In Cancer Lett, 2007
This is illustrated in a study in which we have applied a three-dimensional intact protein analysis system (IPAS) to elucidate detectable protein changes in serum from immunodeficient mice with lung xenografts from orthotopically implanted human A549 lung adenocarcinoma cells.
Hypoxia-inducible factor-1 (HIF-1).
New York City, United States. In Mol Pharmacol, 2006
HIF-1 consists of a constitutively expressed subunit HIF-1beta and an oxygen-regulated subunit HIF-1alpha (or its paralogs HIF-2alpha and HIF-3alpha).