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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Endothelial PAS domain protein 1

HIF-2alpha, HLF, HRF, histamine-releasing factor, TCTP
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: HIF-1alpha, CAN, V1a, HAD, vascular endothelial growth factor
Papers using HIF-2alpha antibodies
Molecular biology: damage control.
Lustig Arthur J., In PLoS ONE, 2006
... HeLa, HEK293T, HLF, HCT116 par, HCT116 DKO and T-Rex-HeLa (Invitrogen) cells were cultured in high-glucose D-MEM (Gibco Life Technologies) supplemented with 10% of ...
Papers on HIF-2alpha
FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro.
Mailleux et al., Paris, France. In Am J Physiol Lung Cell Mol Physiol, Feb 2016
We evaluated the expression of FGF9, FGF18 and FGF receptors (FGFR) in lung tissue from controls and IPF patients and assessed their effect on proliferation, survival, migration and differentiation of control and IPF human lung fibroblasts (HLF).
Milk with and without lactoferrin can influence intestinal damage in a pig model of malnutrition.
Maga et al., Davis, United States. In Food Funct, Feb 2016
We tested the ability of cow milk and milk from transgenic cows expressing human lactoferrin at levels found in human milk (hLF milk) to mitigate the effects of malnutrition at the level of the intestine in a pig model of malnutrition.
Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression.
Ishige et al., Yotsukaidō, Japan. In Oncol Lett, Dec 2015
HLF and PLC/PRF/5 HCC cells were cultured in the presence of niclosamide.
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
Yaspo et al., Düsseldorf, Germany. In Nat Genet, Sep 2015
TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is currently incurable.
Recovering HRFs from overlapping ROIs in fMRI data using thresholding correlations for sparse dictionary learning.
Seghouane et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
Recovering region-specific hemodynamic response function (HRF) in noisy fMRI data is essential to characterize the temporal dynamics of functionally coherent brain regions during activation.
Alternaria alternata and its allergens: a comprehensive review.
Mędrala et al., Wrocław, Poland. In Clin Rev Allergy Immunol, 2014
Others have structural and regulatory functions: Alt a 5 and Alt a 12 comprise the structure of large ribosomal subunits and mediate translation, Alt a 3 is a molecular chaperone, Alt a 7 regulates transcription, Alt a NTF2 facilitates protein import into the nucleus, and Alt a TCTP acts like a cytokine.
Antimicrobial Peptides in Human Sepsis.
Schuerholz et al., Aachen, Germany. In Front Immunol, 2014
Human lactoferrin peptide 1-11 (hLF 1-11) possesses antimicrobial activity and modulates inflammation.
Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway.
Ji et al., Shanghai, China. In Int J Clin Exp Med, 2014
The purpose of the present study was to investigate the protective effect of hawthorn leaf flavonoids (HLF), the dominant bioactive extracts of hawthorn leaves, on high fat diet (HFD)-induced hepatic steatosis and to elucidate its underlying mechanisms.
TCTP as therapeutic target in cancers.
Rocchi et al., Marseille, France. In Cancer Treat Rev, 2014
The translationally controlled tumor protein (TCTP) is a highly conserved protein present in eukaryotic organisms.
Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins.
Veiga et al., Curitiba, Brazil. In Toxicon, 2014
Other toxins with low level of expression also present in the venom include the serine proteases, serine protease inhibitors, hyaluronidases, allergen factors and translationally controlled tumor protein (TCTP).
Human relevance framework evaluation of a novel rat developmental toxicity mode of action induced by sulfoxaflor.
Billington et al., Midland, United States. In Crit Rev Toxicol, 2014
This review evaluates the weight of evidence for this MoA based upon the Bradford Hill criteria, includes a cross-comparison of applied and internal doses in a variety of in vitro, ex vivo, and in vivo study designs, examines alternative MoAs, and applies a Human relevance framework (HRF) to ascertain human risk for this rat MoA.
Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.
Rossi et al., Cambridge, United States. In Cell, 2014
We show that transient expression of six transcription factors Run1t1, Hlf, Lmo2, Prdm5, Pbx1, and Zfp37 imparts multilineage transplantation potential onto otherwise committed lymphoid and myeloid progenitors and myeloid effector cells.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Gieger et al., Freiburg, Germany. In Nat Genet, 2013
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4).
Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia.
Pacak et al., Bethesda, United States. In N Engl J Med, 2012
Here we report two novel somatic gain-of-function mutations in the gene encoding hypoxia-inducible factor 2alpha (HIF2A) in two patients, one presenting with paraganglioma and the other with paraganglioma and somatostatinoma, both of whom had polycythemia.
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Garcia et al., Dallas, United States. In J Biol Chem, 2012
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.
Sharp et al., London, United Kingdom. In Febs Lett, 2012
basal expression of Ctr1 is regulated by HIF2alpha; however, the induction by hypoxia is a HIF2alpha-independent event
HIF-1α protein is upregulated in HIF-2α depleted cells via enhanced translation.
Brüne et al., Frankfurt am Main, Germany. In Febs Lett, 2012
enhanced HIF-1alpha translation as molecular mechanism in HIF-2alpha knockdown (k/d) cells
Overexpression of Arabidopsis translationally controlled tumor protein gene AtTCTP enhances drought tolerance with rapid ABA-induced stomatal closure.
Kim et al., Kwangju, South Korea. In Mol Cells, 2012
TCTP has molecular properties similar to animal TCTPs, such as tubulin- and calcium-binding, and that it functions in ABA-mediated stomatal movement, in addition to regulating the growth of plants.
Reciprocal repression between P53 and TCTP.
Telerman et al., Cachan, France. In Nat Med, 2012
P53 binds to a P53 responsive element that is present in the promoter of TCTP, leading to the transcriptional repression of TCTP
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.
Kawaguchi et al., Tokyo, Japan. In Nat Med, 2010
central transactivator targets several crucial genes for endochondral ossification and may represent a therapeutic target for osteoarthritis
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