GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Hypoxia inducible factor 1, alpha subunit
HIF-1alpha, HIF-1, ARNT, Aryl Hydrocarbon Receptor Nuclear Translocator
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (from
NCBI)
Sponsored links
Papers using
HIF-1alpha
antibodies
Gene expression prowles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum
Supplier
In Gastroenterology Research and Practice, 2009
... , rabbit antismooth muscle actin (SMA) and rabbit anti-HIF-1α (Abcam, Cambridge, UK); rat antimouse ...
Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis
Supplier
In British Journal of Cancer, 2006
... of CD34 blood vessels (Novus Biologicals, LLC, Littleton, CO, USA, QBend10, dilution 1 : 100, no pre-treatment), HIF-1α (NB 100-131B, Novus Biologicals, dilution 1 : 500, pressure cooked ...
Evidence supporting the hypothesis that one of the main functions of the aryl hydrocarbon receptor is mediation of cell stress responses.
Supplier
In PLoS ONE, 2005
... Anti-AhR antibody (RPT9) and anti-ARNT antibody (2B10) were purchased from Abcam Inc ...
Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta
Supplier
In Breast Cancer Research : BCR, 2000
... Anti-ARNT and anti-HIF-1α were obtained from BD Biosciences (San Jose, CA, USA) ...
Nuclear localization and export signals of the human aryl hydrocarbon receptor.
more suppliersSupplier
In PLoS ONE, 1997
... UAS-Arnt transgenic lines were generated by ...
Papers on
HIF-1alpha
Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of HIF-1 and Upregulation of PPARα
New
Newark, United States. In Circ Res, 08 Apr 2013
Hypoxia-inducible factor-1α (HIF-1α) was downregulated while peroxisome proliferator-activated receptor-alpha (PPARα was upregulated in Tg-DN-Nox mice.
Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains.
New
Xiamen, China. In Plos Biol, 28 Feb 2013
The overall structure of VicK is a long-rod dimer that anchors four connected domains: HAMP, Per-ARNT-SIM (PAS), DHp, and catalytic and ATP binding domain (CA).
Effects of the silencing of hypoxia-inducible Factor-1 alpha on metastasis of pancreatic cancer.
New
China. In Eur Rev Med Pharmacol Sci, 28 Feb 2013
Hypoxia-inducible factor-1alpha (HIF-1alpha) is essential for this process, and has been suggested to be a target for cancer therapy.
Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs.
New
Utrecht, Netherlands. In Plos One, Dec 2012
To this end, we analyzed the mRNA expression in the liver of ,, , and other genes involved in this pathway, namely, those for aryl hydrocarbon receptor nuclear translocator 2 (), hypoxia inducible factor 1alpha (), heat shock protein 90AA1 (), cytochromes P450 (, and ), vascular endothelial growth factor A (), nitric oxide synthesase 3 (), and endothelin ().
In Silico Structural and Functional Characterization of the RSUME Splice Variants.
New
Buenos Aires, Argentina. In Plos One, Dec 2012
The NF-κB signaling pathway is inhibited and the HIF-1 pathway is increased more efficiently by the longest RSUME, by means of a greater physical interaction of RSUME267 with the target proteins.
[Is the vascular-endothelial growth factor responsible for the malignancy of lung cancer?].
Review
New
Kantharalak, Thailand. In Pol Merkur Lekarski, Oct 2012
VEGF is synthesized by cancer cells in response to ischemia and a key transcription factor regulating the synthesis of VEGF in hypoxic cell is HIF-1 (hypoxia inducible factor-1).
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae.
New
Impact
Montréal, Canada. In Cell Metab, Oct 2012
Using a genome-wide RNAi approach, we demonstrate that the disruption of genes that increase hydrogen peroxide levels enhance the survival of AMPK mutant dauers by altering both the abundance and the nature of the fatty-acid content in the animal by increasing the HIF-1-dependent expression of several key enzymes involved in fatty-acid biosynthesis.
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells.
Review
New
Baltimore, United States. In Trends Mol Med, Sep 2012
Breast cancers contain regions of intratumoral hypoxia in which reduced O(2) availability activates the hypoxia-inducible factors HIF-1 and HIF-2, which increase the transcription of genes encoding proteins that are required for many important steps in cancer progression.
MicroRNAs and the Warburg Effect: new players in an old arena.
Review
New
Hefei, China. In Curr Gene Ther, Aug 2012
In this review, we will summarize our current understanding of the roles of microRNAs, in particular their interplay with oncogenes/tumor suppressors such as cMyc, HIF-1 and P53, in tumor metabolism.
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
New
Impact
Dallas, United States. In Science, Aug 2012
A key component of this mechanism is a heterodimeric transcriptional activator consisting of two basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) domain protein subunits, CLOCK and BMAL1.
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.
Review
New
Impact
Chicago, United States. In Physiol Rev, Jul 2012
The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of other members of the HIF family of transcriptional activators has provided insight into the molecular underpinnings of oxygen homeostasis.
[Hypoxia, inflammation and phenotypic plasticity of macrophages: the central role of HIF-1 and NFkappaB].
Review
New
In Patol Fiziol Eksp Ter, Jul 2012
Molecular mechanisms of immune cells reaction on hypoxia and the role of transcription factors, HIF-1 and NF-kappaB, are analyzed.
The hedgehog signaling pathway, a new therapeutic target for treatment of ischemic heart disease.
Review
New
Changsha, China. In Pharmazie, Jun 2012
Recent studies show that up-regulated expression of hypoxia-induced factor-1 (HIF-1) and inflamemation in ischemic tissues activate the Hh signaling cascade in a GLI-dependent or independent way, resulting in elevated expression levels of pro-angiogenic and agiogenic factors to facilitate angiogenesis.
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
New
Impact
Nottingham, United Kingdom. In Nat Cell Biol, Feb 2012
Conversely, LIMD1 expression downregulates HIF-1 transcriptional activity in a manner depending on PHD and 26S proteasome activities.
Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.
Impact
Madrid, Spain. In Cell Metab, 2012
This switch involves the hypoxia-inducible transcription factor-1 (HIF-1).
Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.
GeneRIF
Baltimore, United States. In J Clin Invest, 2011
Signaling through herpesvirus entry mediator promoted HIF-1alpha activity in the kidney and subsequently facilitated renal Epo production and erythropoiesis in vivo under normoxic conditions.
Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice.
GeneRIF
Japan. In Biochem Biophys Res Commun, 2011
These findings suggest that HIF-1 in hepatocytes plays protective roles against the progression of diabetes mellitus.
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye.
GeneRIF
Los Angeles, United States. In J Cell Biol, 2011
The HIF-1alpha regulated macrophage migration inhibitory factor and promoted macrophage infiltration that accelerates hyaloidal vessel regression.
Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.
GeneRIF
San Francisco, United States. In Mol Cell, 2011
Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1alpha to control hypoxic response.
[HIF-1 in diabetic nephropathy].
More papers using
HIF-1alpha
antibodies
GeneRIF
In Nihon Jinzo Gakkai Shi, 2010
High glucose activates HIF-1alpha mediated gene expression regulation in glomerular mesangial cells, which causes diabetic nephropathy.
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
Supplier
In British Journal of Cancer, 1995
The staining of hypoxia-associated ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Supplier
In Cell Death & Disease, 1994
... Signaling Technology), anti-Cleaved Caspase-9 (1:250, #9509, Cell Signaling Technology), anti-LC3B (1:500, ab48394, Abcam, Cambridge, UK), anti-HIF-1α (1:500, NB100-479, Novus Biologicals, Cambridge, UK), anti-pimonidazole (1:1000, ...
