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Hypoxia inducible factor 1, alpha subunit

HIF-1alpha, HIF-1, ARNT, Aryl Hydrocarbon Receptor Nuclear Translocator
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, vascular endothelial growth factor, V1a, HAD, Sim
Papers using HIF-1alpha antibodies
Gene expression prowles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum
Dupuy Evelyne et al., In Gastroenterology Research and Practice, 2009
... , rabbit antismooth muscle actin (SMA) and rabbit anti-HIF-1α (Abcam, Cambridge, UK); rat antimouse ...
Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis
Guenther T et al., In British Journal of Cancer, 2006
... of CD34 blood vessels (Novus Biologicals, LLC, Littleton, CO, USA, QBend10, dilution 1 : 100, no pre-treatment), HIF-1α (NB 100-131B, Novus Biologicals, dilution 1 : 500, pressure cooked ...
Evidence supporting the hypothesis that one of the main functions of the aryl hydrocarbon receptor is mediation of cell stress responses.
Uversky Vladimir N., In PLoS ONE, 2005
... Anti-AhR antibody (RPT9) and anti-ARNT antibody (2B10) were purchased from Abcam Inc ...
Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta
Lee YoungJoo et al., In Breast Cancer Research : BCR, 2000
... Anti-ARNT and anti-HIF-1α were obtained from BD Biosciences (San Jose, CA, USA) ...
Nuclear localization and export signals of the human aryl hydrocarbon receptor.
Ellis Steven R., In PLoS ONE, 1997
... UAS-Arnt transgenic lines were generated by ...
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Papers on HIF-1alpha
Hypoxia-inducible factor 3 biology: Complexities and emerging themes.
Duan, United States. In Am J Physiol Cell Physiol, 11 Dec 2015
UNASSIGNED: The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates.
Activation of aryl hydrocarbon receptor mediates suppression of hypoxia inducible factor-dependent erythropoietin expression by indoxyl sulfate.
Watanabe-Akanuma et al., In Am J Physiol Cell Physiol, 11 Dec 2015
In addition to the involvement in the progression of CKD, a recent report indicates that IS suppresses hypoxia inducible factor (HIF)-dependent erythropoietin (EPO) production, suggesting that IS may also contribute to the progression of renal anemia.
Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver.
Gachon et al., Lausanne, Switzerland. In Proc Natl Acad Sci U S A, 09 Dec 2015
Here, we quantified simultaneously temporal transcription, accumulation, and translation of mouse liver mRNAs under physiological light-dark conditions and ad libitum or night-restricted feeding in WT and brain and muscle Arnt-like 1 (Bmal1)-deficient animals.
Design, Synthesis and Structure-Activity Relationship Studies of Novel 4-(1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors.
Hou et al., Changchun, China. In Med Chem, 08 Dec 2015
UNASSIGNED: Hypoxia inducible factor-1 (HIF-1) is a key mediator during cancer cells to adapt tumor hypoxic condition.
Preparation for oxidative stress under hypoxia and metabolic depression: Revisiting the proposal two decades later.
Campos et al., Brasília, Brazil. In Free Radic Biol Med, 23 Oct 2015
These responses would occur mainly through the activation of specific transcription factors (FoxO, Nrf2, HIF-1, NF-κB, and p53) and posttranslational mechanisms, both mechanisms leading to enhanced antioxidant defenses.
Structural integration in hypoxia-inducible factors.
Rastinejad et al., Orlando, United States. In Nature, Sep 2015
Transcriptionally active HIFs consist of HIF-α and ARNT (also called HIF-1β) subunits.
Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.
Mole et al., Erlangen, Germany. In Eur Urol, Sep 2015
Furthermore, HIF-1α activity is commonly diminished by chromosomal deletion in ccRCCs, and increased HIF-1 activity reduces tumor burden in xenograft tumor models.
Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells.
Niles et al., Huntington, United States. In Bmc Cancer, Dec 2014
BACKGROUND: Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis.
The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology.
Rannug et al., Düsseldorf, Germany. In Pharmacol Rev, Dec 2014
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to the Per-ARNT-Sim-basic helix-loop-helix protein family.
Mitochondria-controlled signaling mechanisms of brain protection in hypoxia.
Kirova et al., Moscow, Russia. In Front Neurosci, Dec 2014
This mechanism participates in at least four critical regulatory functions: (1) sensor function related with changes in kinetic properties of complex I and complex II in response to a gradual decrease in ambient oxygen concentration; this function is designed for selection of the most efficient pathway for energy substrate oxidation in hypoxia; (2) compensatory function focused on formation of immediate adaptive responses to hypoxia and hypoxic resistance of the body; (3) transcriptional function focused on activated synthesis of HIF-1 and the genes providing long-term adaptation to low pO2; (4) receptor function, which reflects participation of mitochondria in the intercellular signaling system via the succinate-dependent receptor, GPR91.
Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism.
Li et al., Shanghai, China. In Nutrients, Dec 2014
Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression.
The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease.
Crespo et al., Santander, Spain. In Biomed Res Int, Dec 2014
In the presence of obesity, the proinflammatory state in these patients together with intermittent episodes of hypoxia, characteristic of OSAHS pathogenesis, may lead to an enhanced inflammatory response mediated by a positive feedback loop mechanism that implicates HIF-1 and NFκB.
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.
Denko et al., Columbus, United States. In Cell Metab, Mar 2014
We now identify the mechanism by which HIF-1 activation results in a dramatic reduction in the activity of the key mitochondrial enzyme complex α ketoglutarate dehydrogenase (αKGDH).
Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity.
Chen et al., Shanghai, China. In Cancer Cell, Feb 2014
Here, we report that Cbx4, but not other members of the Cbx family, enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) cells through enhancing HIF-1α sumoylations at K391 and K477 in its two SUMO-interacting motifs-dependent mechanisms and increasing transcriptional activity of HIF-1.
Interactive features of proteins composing eukaryotic circadian clocks.
Young et al., Ithaca, United States. In Annu Rev Biochem, 2013
A series of clock protein structures demonstrate that the PAS (Per/Arnt/Sim) domain has been used with great variation to formulate the transcriptional activators and repressors of the clock.
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
Singh et al., Omaha, United States. In Proc Natl Acad Sci U S A, 2012
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer.
Syrjänen et al., Turku, Finland. In Anticancer Res, 2012
panel consisting of moderate/strong expression of CA IX, positive HIF-1alpha expression and negative/weak GLUT-1 expression in operative samples and negative/weak ezrin expression in biopsies was associated with 47.5-fold risk of death from this disease
Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.
Gamallo et al., Alacant, Spain. In Tumori, 2012
In our study, TT and AA genotypes of C1772T and G1790A hypoxia inducible factor-1alpha single nucleotide polymorphisms were associated with the development of pancreatic cancer.
[Allelic polymorphism of Pro582-->Ser HIF-1alpha to exercise-induced hypoxia adaptation].
In Fiziol Zh, 2011
The frequency of Pro582-->Ser allele of HIF-1alpha gene is significantly higher in athletes involved in sports.
[Dynamic beta-endorphin determination in hematologic patients].
Savchenko et al., In Ter Arkh, 2011
There was a direct correlation between the concentrations of beta-endorphin and HIF-1alpha in patients with acute leukemia
More papers using HIF-1alpha antibodies
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
Hirakawa K et al., In British Journal of Cancer, 1995
The staining of hypoxia-associated ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... Signaling Technology), anti-Cleaved Caspase-9 (1:250, #9509, Cell Signaling Technology), anti-LC3B (1:500, ab48394, Abcam, Cambridge, UK), anti-HIF-1α (1:500, NB100-479, Novus Biologicals, Cambridge, UK), anti-pimonidazole (1:1000, ...
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