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Hypoxia inducible factor 1, alpha subunit

HIF-1alpha, HIF-1, ARNT, Aryl Hydrocarbon Receptor Nuclear Translocator
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, vascular endothelial growth factor, V1a, HAD, Sim
Papers using HIF-1alpha antibodies
Gene expression prowles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum
Supplier
Dupuy Evelyne et al., In Gastroenterology Research and Practice, 2009
... , rabbit antismooth muscle actin (SMA) and rabbit anti-HIF-1α (Abcam, Cambridge, UK); rat antimouse ...
Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis
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Guenther T et al., In British Journal of Cancer, 2006
... of CD34 blood vessels (Novus Biologicals, LLC, Littleton, CO, USA, QBend10, dilution 1 : 100, no pre-treatment), HIF-1α (NB 100-131B, Novus Biologicals, dilution 1 : 500, pressure cooked ...
Evidence supporting the hypothesis that one of the main functions of the aryl hydrocarbon receptor is mediation of cell stress responses.
Supplier
Uversky Vladimir N., In PLoS ONE, 2005
... Anti-AhR antibody (RPT9) and anti-ARNT antibody (2B10) were purchased from Abcam Inc ...
Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta
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Lee YoungJoo et al., In Breast Cancer Research : BCR, 2000
... Anti-ARNT and anti-HIF-1α were obtained from BD Biosciences (San Jose, CA, USA) ...
Nuclear localization and export signals of the human aryl hydrocarbon receptor.
Supplier
Ellis Steven R., In PLoS ONE, 1997
... UAS-Arnt transgenic lines were generated by ...
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Papers on HIF-1alpha
MALDI-mass spectrometric imaging reveals hypoxia-driven lipids and proteins in a breast tumor model.
New
Glunde et al., In Anal Chem, 20 Jun 2015
To date, only a few molecular key players in tumor hypoxia, such as for example hypoxia-inducible factor-1 (HIF-1), have been discovered.
Deoxycholic acid inhibited proliferation and induced apoptosis and necrosis by regulating the activity of transcription factors in rat pancreatic acinar cell line AR42J.
New
Chen et al., Dalian, China. In In Vitro Cell Dev Biol Anim, 20 Jun 2015
A significant increase (P < 0.05) in the activity of transcription factor 2 (ATF2), interferon-stimulated response element (ISRE), NKX-2.5, androgen receptor (AR), p53, and hypoxia-inducible factor-1 (HIF-1) was observed, and the activity of peroxisome proliferator-activated receptor (PPAR), activator protein 1 (AP1), and E2F1 was reduced (P < 0.05).
A2a and a2b adenosine receptors affect HIF-1α signaling in activated primary microglial cells.
New
Gessi et al., Ferrara, Italy. In Glia, 15 Jun 2015
Hypoxia-inducible factor-1 (HIF-1), the main transcription factor of hypoxia-inducible genes, is also involved in the immune response, being regulated in normoxia by inflammatory mediators.
Adipose tissue fibrosis.
New
Eisinger et al., Regensburg, Germany. In World J Diabetes, 15 Jun 2015
Subsequent activation of hypoxia inducible factor 1 (HIF-1) inhibits preadipocyte differentiation and initiates adipose tissue fibrosis.
The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors.
Review
New
Xu et al., Beijing, China. In Cancer Treat Rev, 09 Jun 2015
Hypoxia-inducible factors (HIF-1, 2, 3) predominantly regulate the adaptation to hypoxia at the cellular or organismal level.
ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity.
New
Nakamura et al., Yokohama, Japan. In Bioorg Med Chem Lett, 02 Jun 2015
UNASSIGNED: ortho-Carboranylphenoxy derivatives were synthesized and evaluated for their ability to inhibit hypoxia-induced HIF-1 transcriptional activity using a cell-based reporter gene assay.
The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology.
Review
New
Impact
Rannug et al., Düsseldorf, Germany. In Pharmacol Rev, 30 Apr 2015
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to the Per-ARNT-Sim-basic helix-loop-helix protein family.
Critical protein GAPDH and its regulatory mechanisms in cancer cells.
Review
New
Cui et al., Dongguan, China. In Cancer Biol Med, Mar 2015
Several cancer-related factors, such as insulin, hypoxia inducible factor-1 (HIF-1), p53, nitric oxide (NO), and acetylated histone, not only modulate GAPDH gene expression but also affect protein functions via common pathways.
The association between the rs11549465 polymorphism in the hif-1α gene and cancer risk: a meta-analysis.
Review
New
Liu et al., Nanjing, China. In Int J Clin Exp Med, Dec 2014
PURPOSE: The associations between hypoxia-inducible factor-1 alpha (HIF-1alpha) and clinicopathological characteristics of cancers have been evaluated in various studies, with the conflicting results.
Natural compounds regulate glycolysis in hypoxic tumor microenvironment.
Review
New
Chen et al., Hangzhou, China. In Biomed Res Int, Dec 2014
Hypoxia inducible factor-1 (HIF-1) is one of the key transcription factors that play major roles in tumor glycolysis and could directly trigger Warburg effect.
Molecular mechanism of local drug delivery with Paclitaxel-eluting membranes in biliary and pancreatic cancer: new application for an old drug.
New
Lee et al., Seoul, South Korea. In Gastroenterol Res Pract, Dec 2014
Paclitaxel from the PEM and its diffusion into the tumor inhibited angiogenesis, which involved suppression of mammalian target of rapamycin (mTOR) through regulation of hypoxia inducible factor (HIF-1) and increased apoptosis.
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.
New
Impact
Denko et al., Columbus, United States. In Cell Metab, Mar 2014
We now identify the mechanism by which HIF-1 activation results in a dramatic reduction in the activity of the key mitochondrial enzyme complex α ketoglutarate dehydrogenase (αKGDH).
Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity.
New
Impact
Chen et al., Shanghai, China. In Cancer Cell, Feb 2014
Here, we report that Cbx4, but not other members of the Cbx family, enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) cells through enhancing HIF-1α sumoylations at K391 and K477 in its two SUMO-interacting motifs-dependent mechanisms and increasing transcriptional activity of HIF-1.
Interactive features of proteins composing eukaryotic circadian clocks.
Review
Impact
Young et al., Ithaca, United States. In Annu Rev Biochem, 2013
A series of clock protein structures demonstrate that the PAS (Per/Arnt/Sim) domain has been used with great variation to formulate the transcriptional activators and repressors of the clock.
bHLH-PAS proteins in cancer.
Review
Impact
Whitelaw et al., Adelaide, Australia. In Nat Rev Cancer, 2013
Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcription factors that sense and respond to environmental signals (such as pollutants) or to physiological signals (for example, hypoxia and circadian rhythms) through their two PAS domains.
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
GeneRIF
Singh et al., Omaha, United States. In Proc Natl Acad Sci U S A, 2012
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer.
GeneRIF
Syrjänen et al., Turku, Finland. In Anticancer Res, 2012
panel consisting of moderate/strong expression of CA IX, positive HIF-1alpha expression and negative/weak GLUT-1 expression in operative samples and negative/weak ezrin expression in biopsies was associated with 47.5-fold risk of death from this disease
Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.
GeneRIF
Gamallo et al., Alacant, Spain. In Tumori, 2012
In our study, TT and AA genotypes of C1772T and G1790A hypoxia inducible factor-1alpha single nucleotide polymorphisms were associated with the development of pancreatic cancer.
[Allelic polymorphism of Pro582-->Ser HIF-1alpha to exercise-induced hypoxia adaptation].
GeneRIF
In Fiziol Zh, 2011
The frequency of Pro582-->Ser allele of HIF-1alpha gene is significantly higher in athletes involved in sports.
[Dynamic beta-endorphin determination in hematologic patients].
GeneRIF
Savchenko et al., In Ter Arkh, 2011
There was a direct correlation between the concentrations of beta-endorphin and HIF-1alpha in patients with acute leukemia
More papers using HIF-1alpha antibodies
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
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Hirakawa K et al., In British Journal of Cancer, 1995
The staining of hypoxia-associated ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Supplier
Pereira T S et al., In Cell Death & Disease, 1994
... Signaling Technology), anti-Cleaved Caspase-9 (1:250, #9509, Cell Signaling Technology), anti-LC3B (1:500, ab48394, Abcam, Cambridge, UK), anti-HIF-1α (1:500, NB100-479, Novus Biologicals, Cambridge, UK), anti-pimonidazole (1:1000, ...
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