Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesismore suppliers
In British Journal of Cancer, 2006
... of CD34 blood vessels (Novus Biologicals, LLC, Littleton, CO, USA, QBend10, dilution 1 : 100, no pre-treatment), HIF-1α (NB 100-131B, Novus Biologicals, dilution 1 : 500, pressure cooked ...
Adrenomedullin and tumour microenvironment.
In J Transl Med, 05 Jan 2015
In addition, AM expression gets rapidly activated by hypoxia through a HIF-1¿ mediated mechanism, thus characterizing AM as a major survival factor for tumour cells.
Role of Copper in Regression of Cardiac Hypertrophy.
Chengdu, China. In Pharmacol Ther, 01 Jan 2015
Copper is also required for hypoxia-inducible factor-1 (HIF-1) transcriptional activity, acting on the interaction between HIF-1 and the hypoxia responsible element and the formation of HIF-1 transcriptional complex by inhibiting the factor inhibiting HIF-1.
Cytochrome P450 1 family and cancers.
Ch'ŏngju, South Korea. In J Steroid Biochem Mol Biol, 06 Dec 2014
UNLABELLED: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT).
The Enigmatic Cytoplasmic Regions of KCNH Channels.
Porto, Portugal. In J Mol Biol, Sep 2014
These channels share a general architecture with other voltage-gated ion channels but are distinguished by the presence of an N-terminal Per-Arnt-Sim (PAS) domain and a C-terminal domain with homology to cyclic nucleotide binding domains (referred to as the CNBh domain).
bHLH-PAS proteins in cancer.
Adelaide, Australia. In Nat Rev Cancer, Dec 2013
Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcription factors that sense and respond to environmental signals (such as pollutants) or to physiological signals (for example, hypoxia and circadian rhythms) through their two PAS domains.
The structural mechanism of KCNH-channel regulation by the eag domain.
More papers using
Seattle, United States. In Nature, Oct 2013
The amino-terminal region contains an eag domain, which is composed of a Per-Arnt-Sim (PAS) domain and a PAS-cap domain, whereas the carboxy-terminal region contains a cyclic nucleotide-binding homology domain (CNBHD), which is connected to the pore through a C-linker domain.
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
In Cell Death & Disease, 1994
... Signaling Technology), anti-Cleaved Caspase-9 (1:250, #9509, Cell Signaling Technology), anti-LC3B (1:500, ab48394, Abcam, Cambridge, UK), anti-HIF-1α (1:500, NB100-479, Novus Biologicals, Cambridge, UK), anti-pimonidazole (1:1000, ...