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Hypoxia inducible factor 1, alpha subunit

HIF-1alpha, HIF-1, ARNT, Aryl Hydrocarbon Receptor Nuclear Translocator
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, CAN, V1a, HAD, ACID
Papers using HIF-1alpha antibodies
Gene expression prowles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum
Supplier
Dupuy Evelyne et al., In Gastroenterology Research and Practice, 2009
... , rabbit antismooth muscle actin (SMA) and rabbit anti-HIF-1α (Abcam, Cambridge, UK); rat antimouse ...
Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis
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Guenther T et al., In British Journal of Cancer, 2006
... of CD34 blood vessels (Novus Biologicals, LLC, Littleton, CO, USA, QBend10, dilution 1 : 100, no pre-treatment), HIF-1α (NB 100-131B, Novus Biologicals, dilution 1 : 500, pressure cooked ...
Evidence supporting the hypothesis that one of the main functions of the aryl hydrocarbon receptor is mediation of cell stress responses.
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Uversky Vladimir N., In PLoS ONE, 2005
... Anti-AhR antibody (RPT9) and anti-ARNT antibody (2B10) were purchased from Abcam Inc ...
Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta
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Lee YoungJoo et al., In Breast Cancer Research : BCR, 2000
... Anti-ARNT and anti-HIF-1α were obtained from BD Biosciences (San Jose, CA, USA) ...
Nuclear localization and export signals of the human aryl hydrocarbon receptor.
Supplier
Ellis Steven R., In PLoS ONE, 1997
... UAS-Arnt transgenic lines were generated by ...
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Papers on HIF-1alpha
Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment.
Review
New
Tsiani et al., Canada. In Metabolism, Feb 2016
The regulation of GLUTs by key proliferation and pro-survival pathways including the phosphatidylinositol 3-kinase (PI3K)-Akt, hypoxia-inducible factor-1 (HIF-1), Ras, c-Myc and p53 pathways is discussed.
Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity.
New
Jin et al., Yanji, China. In Oncol Rep, Feb 2016
UNASSIGNED: Hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that mediates the adaptation of tumor cells and tissues to the hypoxic microenvironment, has attracted considerable interest as a potential therapeutic target.
Solution-phase synthesis and biological evaluation of triostin A and its analogues.
New
Nagasawa et al., Gifu, Japan. In Org Biomol Chem, Feb 2016
UNASSIGNED: Triostin A is a biosynthetic precursor of echinomycin which is one of the most potent hypoxia inducible factor 1 (HIF-1) inhibitors.
Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype.
New
Kondratov et al., Cleveland, United States. In Bone, Feb 2016
The transcription factor Brain and Muscle ARNT-like Protein 1 (BMAL1) is a component of the circadian clock and necessary for clock function.
Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.
New
Impact
Kaeberlein et al., Seattle, United States. In Science, Jan 2016
Stabilization of the hypoxia-inducible factor 1 (HIF-1) increases life span and health span in nematodes through an unknown mechanism.
Role of hypoxia-induced VEGF in blood-spinal cord barrier disruption in chronic spinal cord injury.
New
Li et al., Xinhui, China. In Chin J Traumatol, Nov 2015
Hypoxia inducible factor-1 (HIF-1) is a primary regulator of VEGF during hypoxic conditions.
HIF-1α pathway: role, regulation and intervention for cancer therapy.
Review
New
Li et al., Memphis, United States. In Acta Pharm Sin B, Sep 2015
Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target.
Structural integration in hypoxia-inducible factors.
New
Impact
Rastinejad et al., Orlando, United States. In Nature, Sep 2015
Transcriptionally active HIFs consist of HIF-α and ARNT (also called HIF-1β) subunits.
The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology.
Review
Impact
Rannug et al., Düsseldorf, Germany. In Pharmacol Rev, 2014
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to the Per-ARNT-Sim-basic helix-loop-helix protein family.
The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia.
Review
Lewis et al., Adelaide, Australia. In Int J Mol Sci, 2014
Neuronal Per-Arnt-Sim domain protein 4 (Npas4) is an activity-dependent transcription factor whose expression is induced in various brain insults, including cerebral ischemia.
The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease.
Review
Crespo et al., Santander, Spain. In Biomed Res Int, 2014
In the presence of obesity, the proinflammatory state in these patients together with intermittent episodes of hypoxia, characteristic of OSAHS pathogenesis, may lead to an enhanced inflammatory response mediated by a positive feedback loop mechanism that implicates HIF-1 and NFκB.
Mitochondria-controlled signaling mechanisms of brain protection in hypoxia.
Review
Kirova et al., Moscow, Russia. In Front Neurosci, 2014
This mechanism participates in at least four critical regulatory functions: (1) sensor function related with changes in kinetic properties of complex I and complex II in response to a gradual decrease in ambient oxygen concentration; this function is designed for selection of the most efficient pathway for energy substrate oxidation in hypoxia; (2) compensatory function focused on formation of immediate adaptive responses to hypoxia and hypoxic resistance of the body; (3) transcriptional function focused on activated synthesis of HIF-1 and the genes providing long-term adaptation to low pO2; (4) receptor function, which reflects participation of mitochondria in the intercellular signaling system via the succinate-dependent receptor, GPR91.
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.
Impact
Denko et al., Columbus, United States. In Cell Metab, 2014
We now identify the mechanism by which HIF-1 activation results in a dramatic reduction in the activity of the key mitochondrial enzyme complex α ketoglutarate dehydrogenase (αKGDH).
Induction of cap-independent BiP (hsp-3) and Bcl-2 (ced-9) translation in response to eIF4G (IFG-1) depletion in C. elegans.
Keiper et al., Greenville, United States. In Translation (austin), 2013
In this study we address the translational regulation of the stress and apoptosis-related mRNAs in C. elegans: BiP (hsp-3) (hsp-4), Hif-1 (hif-1), p53 (cep-1), Bcl-2 (ced-9) and Apaf-1 (ced-4).
Interactive features of proteins composing eukaryotic circadian clocks.
Review
Impact
Young et al., Ithaca, United States. In Annu Rev Biochem, 2013
A series of clock protein structures demonstrate that the PAS (Per/Arnt/Sim) domain has been used with great variation to formulate the transcriptional activators and repressors of the clock.
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
GeneRIF
Singh et al., Omaha, United States. In Proc Natl Acad Sci U S A, 2012
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer.
GeneRIF
Syrjänen et al., Turku, Finland. In Anticancer Res, 2012
panel consisting of moderate/strong expression of CA IX, positive HIF-1alpha expression and negative/weak GLUT-1 expression in operative samples and negative/weak ezrin expression in biopsies was associated with 47.5-fold risk of death from this disease
Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.
GeneRIF
Gamallo et al., Alacant, Spain. In Tumori, 2012
In our study, TT and AA genotypes of C1772T and G1790A hypoxia inducible factor-1alpha single nucleotide polymorphisms were associated with the development of pancreatic cancer.
[Allelic polymorphism of Pro582-->Ser HIF-1alpha to exercise-induced hypoxia adaptation].
GeneRIF
In Fiziol Zh, 2011
The frequency of Pro582-->Ser allele of HIF-1alpha gene is significantly higher in athletes involved in sports.
[Dynamic beta-endorphin determination in hematologic patients].
GeneRIF
Savchenko et al., In Ter Arkh, 2011
There was a direct correlation between the concentrations of beta-endorphin and HIF-1alpha in patients with acute leukemia
More papers using HIF-1alpha antibodies
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
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Hirakawa K et al., In British Journal of Cancer, 1995
The staining of hypoxia-associated ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Supplier
Pereira T S et al., In Cell Death & Disease, 1994
... Signaling Technology), anti-Cleaved Caspase-9 (1:250, #9509, Cell Signaling Technology), anti-LC3B (1:500, ab48394, Abcam, Cambridge, UK), anti-HIF-1α (1:500, NB100-479, Novus Biologicals, Cambridge, UK), anti-pimonidazole (1:1000, ...
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