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Hypoxia inducible factor 1, alpha subunit

HIF-1alpha, HIF-1, ARNT, Aryl Hydrocarbon Receptor Nuclear Translocator
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, vascular endothelial growth factor, V1a, Sim, HAD
Papers using HIF-1alpha antibodies
Gene expression prowles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum
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Dupuy Evelyne et al., In Gastroenterology Research and Practice, 2009
... , rabbit antismooth muscle actin (SMA) and rabbit anti-HIF-1α (Abcam, Cambridge, UK); rat antimouse ...
Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis
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Guenther T et al., In British Journal of Cancer, 2006
... of CD34 blood vessels (Novus Biologicals, LLC, Littleton, CO, USA, QBend10, dilution 1 : 100, no pre-treatment), HIF-1α (NB 100-131B, Novus Biologicals, dilution 1 : 500, pressure cooked ...
Evidence supporting the hypothesis that one of the main functions of the aryl hydrocarbon receptor is mediation of cell stress responses.
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Uversky Vladimir N., In PLoS ONE, 2005
... Anti-AhR antibody (RPT9) and anti-ARNT antibody (2B10) were purchased from Abcam Inc ...
Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta
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Lee YoungJoo et al., In Breast Cancer Research : BCR, 2000
... Anti-ARNT and anti-HIF-1α were obtained from BD Biosciences (San Jose, CA, USA) ...
Nuclear localization and export signals of the human aryl hydrocarbon receptor.
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Ellis Steven R., In PLoS ONE, 1997
... UAS-Arnt transgenic lines were generated by ...
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Papers on HIF-1alpha
Krüppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition.
New
Zhang et al., Xi'an, China. In Oncol Rep, 31 Dec 2014
Previously, we reported that hypoxia was able to induce invasion and metastasis in gastric cancer and that hypoxia-inducible factor-1 (HIF-1) is a key factor involved in this tumor type.
Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery Doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT).
New
Ernst et al., Chicago, United States. In J Clin Endocrinol Metab, 24 Nov 2014
FGRadv ECs also demonstrated lower aryl hydrocarbon receptor nuclear translocator expression.
Nobiletin suppresses cell viability through AKT Pathways in PC-3 and DU-145 prostate cancer cells.
New
Chen et al., In Bmc Pharmacol Toxicol, 24 Nov 2014
HIF-1alpha expression and AKT phosphorylation were decreased in both cell lines.
[Effect of qubi recipe on changes of oxygen free radical metabolism and hypoxia-inducible factor-1alpha in collagen-induced arthritis rats].
New
Ju et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, 30 Sep 2014
OBJECTIVE: To observe the effect of Qubi Recipe (QR) on the expression of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and hypoxia-inducible factor (HIF)-1alpha in rats with type II collagen-I induced arthritis (CIA), and to explore its therapeutic roles and mechanism.
The Enigmatic Cytoplasmic Regions of KCNH Channels.
Review
New
Robertson et al., Porto, Portugal. In J Mol Biol, 22 Sep 2014
These channels share a general architecture with other voltage-gated ion channels but are distinguished by the presence of an N-terminal Per-Arnt-Sim (PAS) domain and a C-terminal domain with homology to cyclic nucleotide binding domains (referred to as the CNBh domain).
Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node.
Review
New
Domann et al., Iowa City, United States. In Chem Biol Interact, Aug 2014
To regulate gene expression, the AhR requires its binding partner, the aryl hydrocarbon receptor nuclear translocator (ARNT).
Regulation of Wound Healing and Fibrosis by Hypoxia and Hypoxia-Inducible Factor-1.
Review
New
Kim et al., Richardson, United States. In Mol Cells, Jul 2014
Hypoxic responses, mainly mediated by a master transcription factor of oxygen homeostasis, hypoxiainducible factor-1 (HIF-1), have been shown to be critically involved in virtually all processes of wound healing and remodeling.
The Role of Hypoxia-Inducible Factor in Wound Healing.
Review
New
Longaker et al., Stanford, United States. In Adv Wound Care (new Rochelle), Jun 2014
Hypoxia-inducible factor-1 (HIF-1), as the master regulator of oxygen homeostasis, is an important determinant of healing outcomes.
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.
New
Impact
Denko et al., Columbus, United States. In Cell Metab, Mar 2014
We now identify the mechanism by which HIF-1 activation results in a dramatic reduction in the activity of the key mitochondrial enzyme complex α ketoglutarate dehydrogenase (αKGDH).
Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity.
New
Impact
Chen et al., Shanghai, China. In Cancer Cell, Feb 2014
Here, we report that Cbx4, but not other members of the Cbx family, enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) cells through enhancing HIF-1α sumoylations at K391 and K477 in its two SUMO-interacting motifs-dependent mechanisms and increasing transcriptional activity of HIF-1.
[Tissue hypoxiaand related changes of homeostasis during vibration load in athletes: influence on physical performance].
New
In Fiziol Zh, Dec 2013
Simultaneously, it is activated such a HIF-1 alpha-dependent process as erythropoiesis: the contents of red blood cells increases at the end of the study to 6.04+/-0.11x10(12)
Interactive features of proteins composing eukaryotic circadian clocks.
New
Impact
Young et al., Ithaca, United States. In Annu Rev Biochem, Dec 2013
A series of clock protein structures demonstrate that the PAS (Per/Arnt/Sim) domain has been used with great variation to formulate the transcriptional activators and repressors of the clock.
Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate.
Review
New
Contreras et al., Tijuana, Mexico. In Front Oncol, Dec 2013
Measures which inhibit the constitutive hypoxia-inducible factor-1 (HIF-1) activity in cancers (such as salsalate and mTORC1 inhibitors, or an improvement of tumor oxygenation), or that inhibit the HIF-1-inducible pyruvate dehydrogenase kinase (such as dichloroacetate), can be expected to increase pyruvate oxidation.
bHLH-PAS proteins in cancer.
Review
New
Impact
Whitelaw et al., Adelaide, Australia. In Nat Rev Cancer, Dec 2013
Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcription factors that sense and respond to environmental signals (such as pollutants) or to physiological signals (for example, hypoxia and circadian rhythms) through their two PAS domains.
The structural mechanism of KCNH-channel regulation by the eag domain.
New
Impact
Zagotta et al., Seattle, United States. In Nature, Oct 2013
The amino-terminal region contains an eag domain, which is composed of a Per-Arnt-Sim (PAS) domain and a PAS-cap domain, whereas the carboxy-terminal region contains a cyclic nucleotide-binding homology domain (CNBHD), which is connected to the pore through a C-linker domain.
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
GeneRIF
Singh et al., Omaha, United States. In Proc Natl Acad Sci U S A, 2012
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer.
GeneRIF
Syrjänen et al., Turku, Finland. In Anticancer Res, 2012
panel consisting of moderate/strong expression of CA IX, positive HIF-1alpha expression and negative/weak GLUT-1 expression in operative samples and negative/weak ezrin expression in biopsies was associated with 47.5-fold risk of death from this disease
Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.
GeneRIF
Gamallo et al., Alacant, Spain. In Tumori, 2012
In our study, TT and AA genotypes of C1772T and G1790A hypoxia inducible factor-1alpha single nucleotide polymorphisms were associated with the development of pancreatic cancer.
[Allelic polymorphism of Pro582-->Ser HIF-1alpha to exercise-induced hypoxia adaptation].
GeneRIF
In Fiziol Zh, 2011
The frequency of Pro582-->Ser allele of HIF-1alpha gene is significantly higher in athletes involved in sports.
[Dynamic beta-endorphin determination in hematologic patients].
GeneRIF
Savchenko et al., In Ter Arkh, 2011
There was a direct correlation between the concentrations of beta-endorphin and HIF-1alpha in patients with acute leukemia
More papers using HIF-1alpha antibodies
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
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Hirakawa K et al., In British Journal of Cancer, 1995
The staining of hypoxia-associated ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Supplier
Pereira T S et al., In Cell Death & Disease, 1994
... Signaling Technology), anti-Cleaved Caspase-9 (1:250, #9509, Cell Signaling Technology), anti-LC3B (1:500, ab48394, Abcam, Cambridge, UK), anti-HIF-1α (1:500, NB100-479, Novus Biologicals, Cambridge, UK), anti-pimonidazole (1:1000, ...
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