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Hypoxia inducible factor 1, alpha subunit

HIF-1alpha, HIF-1, ARNT, Aryl Hydrocarbon Receptor Nuclear Translocator
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, vascular endothelial growth factor, V1a, Sim, HAD
Papers using HIF-1alpha antibodies
Gene expression prowles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum
Supplier
Dupuy Evelyne et al., In Gastroenterology Research and Practice, 2009
... , rabbit antismooth muscle actin (SMA) and rabbit anti-HIF-1α (Abcam, Cambridge, UK); rat antimouse ...
Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis
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Guenther T et al., In British Journal of Cancer, 2006
... of CD34 blood vessels (Novus Biologicals, LLC, Littleton, CO, USA, QBend10, dilution 1 : 100, no pre-treatment), HIF-1α (NB 100-131B, Novus Biologicals, dilution 1 : 500, pressure cooked ...
Evidence supporting the hypothesis that one of the main functions of the aryl hydrocarbon receptor is mediation of cell stress responses.
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Uversky Vladimir N., In PLoS ONE, 2005
... Anti-AhR antibody (RPT9) and anti-ARNT antibody (2B10) were purchased from Abcam Inc ...
Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta
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Lee YoungJoo et al., In Breast Cancer Research : BCR, 2000
... Anti-ARNT and anti-HIF-1α were obtained from BD Biosciences (San Jose, CA, USA) ...
Nuclear localization and export signals of the human aryl hydrocarbon receptor.
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Ellis Steven R., In PLoS ONE, 1997
... UAS-Arnt transgenic lines were generated by ...
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Papers on HIF-1alpha
Decreased expression of neuronal Per-Arnt-Sim domain protein 4 gene in the hippocampus of a post-stroke depression rat model.
New
Song et al., Xinxiang, China. In Exp Ther Med, 30 Apr 2014
UNLABELLED: Neuronal Per-Arnt-Sim domain protein 4 (NPAS4) is important in regulating transcription and function in the limbic system and in brain development.
NPAS3 variants in schizophrenia: A neuroimaging study.
New
Tibbo et al., In Bmc Med Genet, 27 Apr 2014
Studies support a role for the neuronal Per-Arnt-Sim 3 (NPAS3) gene in processes that are essential for normal brain development.
Effects of Acute Systematic Hypoxia on Human Urinary Metabolites Using LC-MS-Based Metabolomics.
New
Wang et al., Taonan, China. In High Alt Med Biol, 25 Apr 2014
1-Methyladenosine was also highly upregulated from MH to SH and may be a very sensitive biomarker that reflects cellular hypoxia, due to its potential connection to HIF-1.
Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease.
New
Zhang et al., In Respir Res, 25 Apr 2014
The expression of hypoxia inducible factor (HIF-1alpha) and stromal cell-derived factor-1 (SDF-1), and relationship between HIF-1alpha and SDF-1 in a hypoxic cell model were analyzed by real-time PCR, western blotting, and enzyme-linked immunosorbent assay.
Enzyme 15-lipoxygenase 1 promotes hypoxia-inducible factor 1α turnover and reduces vascular endothelial growth factor expression: implications for angiogenesis.
New
Simons et al., United States. In Cancer Med, 25 Apr 2014
UNLABELLED: Hypoxia-inducible factor 1α (HIF-1α) is the regulatory subunit of the heterodimeric HIF-1 that plays a critical role in transcriptional regulation of genes in angiogenesis and hypoxic adaptation, while fatty acid metabolism mediated by lipoxygenases has been implicated in a variety of pathogeneses, including cancers.
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.
New
Impact
Denko et al., Columbus, United States. In Cell Metab, 04 Mar 2014
We now identify the mechanism by which HIF-1 activation results in a dramatic reduction in the activity of the key mitochondrial enzyme complex α ketoglutarate dehydrogenase (αKGDH).
[Effect of Qinghuang Powder combined Chinese herbs for Pi-strengthening and Shen-reinforcing on HIF-1alpha in bone marrow mononuclear cells of myelodysplastic syndrome patients: an experimental research].
New
Ma et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, 28 Feb 2014
OBJECTIVE: To study the effect of Qinghuang Powder (QHP) combined Chinese herbs for Pi-strengthening and Shen-reinforcing (CHPSSR) on hypoxia-inducible factor 1alpha (HIF-1alpha) in bone marrow mononuclear cells of myelodysplastic syndrome (MDS) patients.
Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity.
New
Impact
Chen et al., Shanghai, China. In Cancer Cell, 13 Feb 2014
Here, we report that Cbx4, but not other members of the Cbx family, enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) cells through enhancing HIF-1α sumoylations at K391 and K477 in its two SUMO-interacting motifs-dependent mechanisms and increasing transcriptional activity of HIF-1.
bHLH-PAS proteins in cancer.
Review
New
Impact
Whitelaw et al., Adelaide, Australia. In Nat Rev Cancer, Dec 2013
Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcription factors that sense and respond to environmental signals (such as pollutants) or to physiological signals (for example, hypoxia and circadian rhythms) through their two PAS domains.
Hydrogen peroxide sensing, signaling and regulation of transcription factors.
Review
New
Antunes et al., Lisbon, Portugal. In Redox Biol, Dec 2013
UNLABELLED: The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-κB, NOTCH, SP1 and SCREB-1) are reviewed.
The structural mechanism of KCNH-channel regulation by the eag domain.
New
Impact
Zagotta et al., Seattle, United States. In Nature, Oct 2013
The amino-terminal region contains an eag domain, which is composed of a Per-Arnt-Sim (PAS) domain and a PAS-cap domain, whereas the carboxy-terminal region contains a cyclic nucleotide-binding homology domain (CNBHD), which is connected to the pore through a C-linker domain.
Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans.
New
Impact
Horvitz et al., Cambridge, United States. In Science, Sep 2013
Key aspects of ischemia-reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2-ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2-sensing HIF (hypoxia-inducible factor) hydroxylase EGL-9.
Putative role of HIF transcriptional activity in melanocytes and melanoma biology.
Review
New
Slominski et al., Memphis, United States. In Dermatoendocrinol, May 2013
UNLABELLED: Hypoxia-inducible factor-1α (HIF-1α) is a highly oxygen sensitive bHLH protein that is part of the heterodimeric HIF-1 transcription factor.
[Mithochondria signaling in adaptation to hypoxia].
Review
Luk'ianova, In Fiziol Zh, 2012
Transient, reversible, compensatory activation of respiratory chain complex II is a major mechanism of urgent adaptation to hypoxia necessary for 1) succinate- related energy synthesis in conditions of oxygen deficiency and formation of urgent resistance in the body; 2) succinate- related stabilization of HIF-1alpha and initiation of its transcriptional activity related with formation of urgent and long-term adaptation; 3) succinate- related activation of a succinate-specific receptor GPR91.
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
GeneRIF
Singh et al., Omaha, United States. In Proc Natl Acad Sci U S A, 2012
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer.
GeneRIF
Syrjänen et al., Turku, Finland. In Anticancer Res, 2012
panel consisting of moderate/strong expression of CA IX, positive HIF-1alpha expression and negative/weak GLUT-1 expression in operative samples and negative/weak ezrin expression in biopsies was associated with 47.5-fold risk of death from this disease
Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.
GeneRIF
Gamallo et al., Alacant, Spain. In Tumori, 2012
In our study, TT and AA genotypes of C1772T and G1790A hypoxia inducible factor-1alpha single nucleotide polymorphisms were associated with the development of pancreatic cancer.
[Allelic polymorphism of Pro582-->Ser HIF-1alpha to exercise-induced hypoxia adaptation].
GeneRIF
In Fiziol Zh, 2011
The frequency of Pro582-->Ser allele of HIF-1alpha gene is significantly higher in athletes involved in sports.
[Dynamic beta-endorphin determination in hematologic patients].
GeneRIF
Savchenko et al., In Ter Arkh, 2011
There was a direct correlation between the concentrations of beta-endorphin and HIF-1alpha in patients with acute leukemia
Enhancement of cancer stem cell susceptibility to conventional treatments through complementary yoga therapy: possible cellular and molecular mechanisms.
Review
Koka et al., In J Stem Cells, 2011
Cancer stem cells are critically dependant on the hypoxia-inducible factor-1 (HIF-1) for survival, self-renewal, tumor growth and maintenance of their undifferentiated phenotype.
More papers using HIF-1alpha antibodies
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
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Hirakawa K et al., In British Journal of Cancer, 1995
The staining of hypoxia-associated ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Supplier
Pereira T S et al., In Cell Death & Disease, 1994
... Signaling Technology), anti-Cleaved Caspase-9 (1:250, #9509, Cell Signaling Technology), anti-LC3B (1:500, ab48394, Abcam, Cambridge, UK), anti-HIF-1α (1:500, NB100-479, Novus Biologicals, Cambridge, UK), anti-pimonidazole (1:1000, ...
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