Tagged Chromosomal Insertion Site System: A Method to Study Lamina-Associated Chromatin.
Baltimore, United States. In Methods Enzymol, Dec 2015
This system can be used to study the minimal DNA sequences that target the nuclear periphery (or other nuclear compartments), allowing researchers to understand how genome-wide results obtained, for example, by DNA adenine methyltransferase identification, chromosome conformation capture (HiC), or related methods, connect to the actual organization of DNA and chromosomes at the single-cell level.
The statistical-mechanics of chromosome conformation capture.
Auckland, New Zealand. In Nucleus, 2013
Proximity ligation assays commonly known as chromosome conformation capture (3C) and 3C based methodologies (e.g., GCC, HiC and ChIA-Pet) are increasingly being incorporated into empirical studies to investigate the role that three-dimensional genome structure plays in the regulation of phenotype.