gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transforming growth factor beta 1 induced transcript 1

Hic-5, ARA55
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Hic, CAN, LIM, PTC3, ARA54
Papers on Hic-5
Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ.
New
Centrella et al., New Haven, United States. In Gene, Dec 2015
Notably, DHT suppresses plasminogen activator inhibitor gene promoter activity, but synergistically increases Smad dependent gene promoter activity in TGF-β induced cells, which are differentially sensitive to AR mutations and the AR co-regulator ARA55.
Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.
Noda et al., Okazaki, Japan. In Plos One, 2014
In the present study, we showed that Tyr-554 phosphorylation reduced the association of Git1 with the FAH-domain-binding proteins, paxillin and Hic-5, based on immunoprecipitation experiments using the Tyr-554 mutants of Git1.
Interactions between E6, FAK, and GIT1 at paxillin LD4 are necessary for transformation by bovine papillomavirus 1 E6.
Vande Pol et al., Charlottesville, United States. In J Virol, 2014
UNLABELLED: Bovine papillomavirus 1 E6 interacts with two similar proteins that regulate cell attachment and cell migration called paxillin (PXN) and HIC-5 (also known as HIC5, ARA55, HIC-5, TSC-5, and TGFB1I1).
A HIC-5- and KLF4-dependent mechanism transactivates p21(Cip1) in response to anchorage loss.
Shibanuma et al., Tokyo, Japan. In J Biol Chem, 2012
RNAi experiments revealed that KLF4 and a multidomain adaptor protein, hydrogen peroxide-inducible clone 5 (HIC-5), were critically involved in DRE transactivation.
Hic-5 controls BMP4 responses in prostate cancer cells through interacting with Smads 1, 5 and 8.
GeneRIF
Danielpour et al., Cleveland, United States. In Oncogene, 2012
these results provide the first evidence for a physical and mutual functional interaction between Hic-5 and the BMP signaling pathway.
[Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target].
GeneRIF
Kim-Kaneyama, Tokyo, Japan. In Seikagaku, 2012
It plays a roll in extracellular matrix remodeling and the signal transduction via reactive oxygen species. (review)
Transforming growth factor-β1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein.
GeneRIF
Zhou et al., Albany, United States. In J Biol Chem, 2012
Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein.
Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis.
GeneRIF
Kagami et al., Tokushima, Japan. In Nephron Exp Nephrol, 2011
Findings suggest that hydrogen peroxide-inducible clone-5 (Hic-5) is involved in changes in the mesangial cells (MCs) phenotype to produce abnormal extracellular matrix remodeling in glomerulonephritis (GN).
HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth.
Nose et al., Tokyo, Japan. In Int J Cell Biol, 2011
HIC-5 is a multidomain LIM protein homologous to paxillin that serves as a molecular scaffold at focal adhesions and in the nucleus.
Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells.
GeneRIF
Itami et al., In J Dermatol Sci, 2011
Androgen receptor transactivity is potentiated by TGF-beta1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells.
Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation.
GeneRIF
Chang et al., Rochester, United States. In J Biol Chem, 2011
DNA-binding domain acetylation in the TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation
A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men.
Fabbri et al., In J Biol Regul Homeost Agents, 2011
To this end, we evaluated the gene expression profile of 19 genes (AKT2, CCND1, GSK3ALPHA, IGF1, GSK3BETA, FOXO3, IL6, IGFBP2, UGT2B17, ARA55, CREBBP, CYP11A, HSD17B1, HSD17B7, UGT2B7, SELADIN 1, CLU, PGC1, AKR1C1) selected according their function in the androgen pathways, in a series of 11 hypogonadal men pharmacologically treated with T. We noted that 7 genes were differentially expressed, five of them were up-regulated (AKT2 FC=2.39,
Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness.
GeneRIF
Bhowmick et al., Nashville, United States. In Oncogene, 2011
Hic-5/ARA55 expression in response to castration-enabled epithelial regression through the repression of c-myc gene at the chromatin level.
Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla.
Review
Itami et al., Suita, Japan. In J Dermatol Sci, 2011
Additionally, AR coactivator Hic-5/ARA55 is highly expressed in dermal papilla cells of hair follicles from androgen-sensitive sites such as AGA and beard.
Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes.
GeneRIF
Keller et al., Albany, United States. In J Mol Cell Cardiol, 2009
These findings demonstrate a novel role for hic-5 in the regulation of actin cytoskeleton and fetal gene expression.
Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients.
Bergh et al., Umeå, Sweden. In Prostate, 2009
METHODS: AR immunostaining was evaluated in relation to stroma morphology, expression of AR co-activator ARA55, tumor characteristics and clinical outcome in normal and prostate cancer (PCa) tissue obtained at transurethral resection in men treated with expectancy, and in diagnostic transrectal core biopsies in men treated with surgical castration.
Hic-5/ARA55: a prostate stroma-specific AR coactivator.
Review
GeneRIF
DeFranco et al., Pittsburgh, United States. In Steroids, 2007
Review highlights the role that Hic-5 may play in regulating androgen-induced growth factor signaling and/or cytokine expression in the prostate.
Identification and characterization of androgen receptor associated coregulators in prostate cancer cells.
Review
Chang et al., Rochester, United States. In J Biol Regul Homeost Agents, 2001
The LBD-interacting proteins ARA70, ARA55 and ARA54 were first characterized and ARA70 was found to have a relatively higher specificity for the AR in human prostate cancer DU145 cells.
Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer.
Review
Chang et al., Rochester, United States. In J Formos Med Assoc, 2000
Several new androgen receptor (AR) coregulators, including ARA70, ARA55, ARA54, ARA160 and ARA24, associated with the N-terminal or the ligand-binding domain (LBD) of AR, have been identified by our group.
Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators.
Review
Chang et al., Rochester, United States. In Keio J Med, 1999
Several new androgen receptor (AR) cofactors, associated to the ligand binding domain of AR, have been identified by our group and named AR associated protein (ARA)70, ARA55, and ARA54.
share on facebooktweetadd +1mail to friends