Pediatric targeted therapy: Clinical feasibility of personalized diagnostics in children with relapsed and progressive tumors.
Heidelberg, Germany. In Brain Pathol, Nov 2015
10 markers (HDAC2, HR23B, p-AKT, p-ERK, p-S6, p-EGFR, PDGFR-alpha/beta, p53, and BRAFV600E) were analyzed by immunohistochemistry. Pediatric patients with tumors independent of the histological diagnosis, with relapse or progression after treatment according to standard protocols were included.
eNERgizing pluripotent gene transcription.
Boston, United States. In Cell Stem Cell, 2011
(2011) in the most recent issue of Cell demonstrates that the XPC/RAD23B/CETN2 nucleotide excision repair complex additionally functions as a transcriptional coactivator of Oct4/Sox2, critically regulating maintenance and reestablishment of stem cell pluripotency.