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Keratin 81

hHb1, K81
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAIR, cytokeratin, hHb6, CAN, HB-5
Papers on hHb1
Protection of Drosophila chromosome ends through minimal telomere capping.
New
Loppin et al., Villeurbanne, France. In J Cell Sci, Jun 2015
We show that the exhaustion of HOAP results in a dramatic reduction of other capping proteins at telomeres, including K81 [encoded by ms(3)K81], which is essential for male fertility.
Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.
Li et al., Hefei, China. In Sci Rep, 2014
Here, we report that p300, which has histone acetyltransferase (HAT) activity, interacts with and acetylates RORγt at its K81 residue.
Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer.
Lei et al., Shanghai, China. In Nat Commun, 2014
Folate deprivation upregulates K81 acetylation and destabilizes MAT IIα to moderate cell proliferation, whereas a single mutation at K81 reverses the proliferative disadvantage of cancer cells upon folate deprivation.
In vitro assembly properties of human type I and II hair keratins.
Ando et al., Saga, Japan. In Cell Struct Funct, 2013
In this study, recombinant proteins of human type I hair keratins (K35, K36 and K38) and type II hair keratins (K81 and K85) were prepared using bacterial expression systems.
Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation.
GeneRIF
Bladé et al., Barcelona, Spain. In Clin Cancer Res, 2012
Overall survival was significantly longer in multiple myeloma patients with KRT81 rs3660 C/C variant
Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins.
Omary et al., Ulm, Germany. In J Cell Sci, 2012
We analyzed keratin sequences from many species: K1, K2, K5, K9, K10, K14 were studied as representatives of epidermal keratins, and compared with K7, K8, K18, K19, K20 and K31, K35, K81, K85, K86, which represent simple-type (single-layered or glandular) epithelial and hair keratins, respectively.
Repeated evolution of testis-specific new genes: the case of telomere-capping genes in Drosophila.
Loppin et al., Villeurbanne, France. In Int J Evol Biol, 2011
hiphop and its testis-specific paralog K81 are critical for the protection of chromosome ends in somatic cells and male gametes, respectively.
Target molecular simulations of RecA family protein filaments.
Wang et al., Tainan City, Taiwan. In Int J Mol Sci, 2011
We find 11 rotary residues (R72, T75-K81, M84, V86 and K87) and five zero rotary residues (I71, K74, E82, R83 and K88) in the simulations.
Mechanical and biological properties of keratose biomaterials.
Van Dyke et al., Winston-Salem, United States. In Biomaterials, 2011
Mass spectrometry identified the major protein constituents as a heterogeneous mixture of 15 hair keratins (type I: K31-35 and K37-39, and type II: K81-86) with small amounts of epithelial keratins which exist in monomeric, dimeric, multimeric, and even degraded forms.
Circumventing heterozygosity: sequencing the amplified genome of a single haploid Drosophila melanogaster embryo.
Stevens et al., Davis, United States. In Genetics, 2011
Here we present a simple genome sequencing protocol based on the whole-genome amplification of the gynogenetically derived haploid genome of a progeny of females mated to males homozygous for the recessive male sterile mutation, ms(3)K81.
Keratin gene mutations in disorders of human skin and its appendages.
Review
Mukhtar et al., Madison, United States. In Arch Biochem Biophys, 2011
Examples include epidermolysis bullosa simplex (EBS; K5, K14), keratinopathic ichthyosis (KPI; K1, K2, K10) i.e. epidermolytic ichthyosis (EI; K1, K10) and ichthyosis bullosa of Siemens (IBS; K2), pachyonychia congenita (PC; K6a, K6b, K16, K17), epidermolytic palmo-plantar keratoderma (EPPK; K9, (K1)), monilethrix (K81, K83, K86), ectodermal dysplasia (ED; K85) and steatocystoma multiplex.
Epigenetic maintenance of telomere identity in Drosophila: buckle up for the sperm ride.
Loppin et al., Lyon, France. In Cell Cycle, 2011
HipHop and K81 are two recently identified paralogous capping proteins with complementary expression patterns.
Paternal imprint essential for the inheritance of telomere identity in Drosophila.
Rong et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2011
The ms(3)k81 (k81) gene is a duplication of hiphop that encodes a telomeric protein.
A dual role for KRT81: a miR-SNP associated with recurrence in non-small-cell lung cancer and a novel marker of squamous cell lung carcinoma.
GeneRIF
Monzo et al., Barcelona, Spain. In Plos One, 2010
KRT81 has emerged as a promising immunohistochemical marker for the identification of squamous cell lung carcinoma
The DNA binding and bending activities of truncated tail-less HMGB1 protein are differentially affected by Lys-2 and Lys-81 residues and their acetylation.
Pasheva et al., Sofia, Bulgaria. In Int J Biol Sci, 2010
Such a conclusion is further confirmed by the experiments carried out with CBP-acetylated proteins: acetylation of Lys-2 in mutant protein K81/A81 alleviated DNA bending and induced DNA end-joining.
Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA.
GeneRIF
Gat et al., Jerusalem, Israel. In Differentiation, 2008
Transfected p65 induces transcriptional activation of Hb1.
Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues.
GeneRIF
Tate et al., Dunedin, New Zealand. In J Biol Chem, 2008
the ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals
[Origin of viviparity and genomic imprinting in mammals: a view from a retrotransposon-derived imprinted gene PEG10].
GeneRIF
Ishino et al., In Tanpakushitsu Kakusan Koso, 2007
It is a retrotransposon-derived imprinted gene and plays a essential role in placental formation.(review)
The molecular genetics of keratin disorders.
Review
Smith, Dundee, United Kingdom. In Am J Clin Dermatol, 2002
These include ichthyosis bullosa of Siemens (K2e), epidermolytic palmoplantar keratoderma (K1, K9), pachyonychia congenita (K6a, K6b, K16, K17), white sponge nevus (K4, K13), Meesmann's corneal dystrophy (K3, K12), cryptogenic cirrhosis (K8, K18) and monilethrix (hHb6, hHb1).In general, these disorders are inherited as autosomal dominant traits and the mutations act in a dominant-negative manner.
Paternal effects in Drosophila: implications for mechanisms of early development.
Review
Wakimoto et al., Seattle, United States. In Curr Top Dev Biol, 1997
Analyses of the paternal effects mutations sneaky, K81, paternal loss, and Horka have identified paternal products that play a role in mediating the initial response of the sperm to the egg cytoplasm, participation of the male pronucleus in the first mitosis, and stable inheritance of the paternal chromosomes in the early embryo.
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