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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Hgb, Cytoglobin, Cygb, STAP
This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, ACID, Serum albumin
Papers on Hgb
Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins reveal functional divergences with mammalian proteins.
Tejero et al., Pittsburgh, United States. In Nitric Oxide, Jan 2016
UNASSIGNED: Neuroglobin (Ngb) and cytoglobin (Cygb) are two six-coordinate heme proteins of unknown physiological function.
Assessment of Anemia and Quality of Life in Patients With Renal Transplantation.
Seyahi et al., İstanbul, Turkey. In Transplant Proc, Dec 2015
METHODS: Anemia was defined by a hemoglobin (Hgb) level of <12 g/dL and severe anemia by a Hgb level of <10 g/dL.
Hematologic and serum biochemical reference intervals for wild Tasmanian devils (Sarcophilus harrisii).
Canfield et al., Sydney, Australia. In Vet Clin Pathol, Dec 2015
Significant seasonal or reproductive status variation in adult males or breeding females were observed for PCV, HGB, RBC, MCHC, MCH, MCV, neutrophils and lymphocytes, fibrinogen, total plasma protein, AST, ALP, ALT, GLDH, bilirubin, urea, calcium, chloride, total protein, albumin, A:G, and glucose.
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
Kawada et al., Ōsaka, Japan. In Histol Histopathol, Dec 2015
UNASSIGNED: Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis and cancer.
NMRe: a web server for NMR protein structure refinement with high-quality structure validation scores.
Lee et al., Taejŏn, South Korea. In Bioinformatics, Nov 2015
The previously developed knowledge-based energy function STAP (Statistical Torsion Angle Potential) was used for NMRe refinement.
A Hispanic female patient with heartburn: A rare presentation of Paroxysmal Nocturnal Hemoglobinuria.
Cáceres-Pérkins et al., In Bol Asoc Med P R, Jul 2015
CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia (platelet count 59 x 109/L).
Long-Term Follow-Up of Renal Function in Living Kidney Donors in a Single Center.
Yin et al., Nanjing, China. In Ann Transplant, 2014
The hemoglobin (HGB) decreased and had significant differences on day 1 and week 1 compared with pre-operation HGB levels.
Cytoglobin as a Biomarker in Cancer: Potential Perspective for Diagnosis and Management.
Bahorun et al., Mauritius. In Biomed Res Int, 2014
In this line, cytoglobin (Cygb), a ubiquitously found protein, has been actively reviewed for its functional role.
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway.
Bjørås et al., Oslo, Norway. In Sci Rep, 2014
HIF1A, SP6, E2F8 and TCF3), antioxidant genes (PRDX4, PTGS1 and CYGB) and numerous genes of the p53 signaling pathway involved in cell-cycle arrest (i.e.
Cytoglobin in tumor hypoxia: novel insights into cancer suppression.
Nag et al., New Delhi, India. In Tumour Biol, 2014
Emerging new and intriguing roles of cytoglobin (Cygb) have attracted considerable attention of cancer researchers in recent years.
EPB42-Related Hereditary Spherocytosis
Begtrup et al., Seattle, United States. In Unknown Journal, 2014
The diagnosis of EPB42-HS is established by the presence of biallelic pathogenic variants in EPB42 (encoding protein 4.2) MANAGEMENT: Treatment of manifestations: Treatment for mild EPB42-HS (Hgb 11-15 g/dL, reticulocytes 3%-8%) includes folic acid supplementation (400 µg once daily up to age 1 year, then 1 mg once daily thereafter) and RBC transfusion as needed for a hemolytic or aplastic crisis.
Bidirectional developmental potential in reprogrammed cells with acquired pluripotency.
Wakayama et al., Kōbe, Japan. In Nature, 2014
We recently discovered an unexpected phenomenon of somatic cell reprogramming into pluripotent cells by exposure to sublethal stimuli, which we call stimulus-triggered acquisition of pluripotency (STAP).
Stimulus-triggered fate conversion of somatic cells into pluripotency.
Vacanti et al., Boston, United States. In Nature, 2014
Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the introduction of transcription factors.
Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain.
Hundahl et al., Copenhagen, Denmark. In Biochem Biophys Res Commun, 2012
This suggests that Cytoglobin is likely not important for global neuronal protection following ischemia and the role of Cytoglobin in relation to endogenous neuroprotection remains unresolved.
Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric oxide concentration.
Zweier et al., Columbus, United States. In Biochemistry, 2012
Coexistence of Cygb with efficient reductants in tissues allows Cygb to function as an oxygen-dependent regulator of nitric oxide (NO) decay. A related kinetic model predicts the NO consumption rate.
Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate.
Humphrey et al., Saint Louis, United States. In Prostate, 2012
Cytoglobin, a protein that can be induced in response to oxidative stress, is elevated in most atrophic foci in adenocarcinoma of the prostate, suggesting hypoxic, and/or oxidative damage.
Chromosome 17q25 genes, RHBDF2 and CYGB, in ovarian cancer.
Tonin et al., Montréal, Canada. In Int J Oncol, 2012
RHBDF2 and CYGB may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease.
Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells.
Hodges et al., Birmingham, United Kingdom. In Plos One, 2011
normal physiological concentrations of cytoglobin do not offer cytoprotection from reactive oxygen species
Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia.
Levine et al., Hamilton, Canada. In J Clin Oncol, 2007
Eligible patients were required to have NSCLC unsuitable for curative therapy and baseline hemoglobin (Hgb) levels less than 121 g/L.
Phase I trial to determine the safety, pharmacodynamics, and pharmacokinetics of RSR13, a novel radioenhancer, in newly diagnosed glioblastoma multiforme.
Gerber et al., Baltimore, United States. In J Clin Oncol, 1999
RSR13, a synthetic allosteric modifier of hemoglobin (HgB), is a novel radioenhancing agent that noncovalently binds to HgB, thereby reducing oxygen binding affinity and increasing tissue oxygen release to hypoxic tissues.
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