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Hexokinase 1

Hexokinase
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, Insulin, hK2, V1a
Papers using Hexokinase antibodies
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Supplier
Ng Davis T.W. et al., In The Journal of Cell Biology, 2003
... Anti-hexokinase antibody was purchased from United States Biological Inc ...
High glucose-induced oxidative stress and mitochondrial dysfunction in neurons.
Supplier
Bush Ashley I., In PLoS ONE, 2001
... Goat polyclonal anti-cytochrome c oxidase and monoclonal anti-hexokinase-1 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on Hexokinase
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.
New
Hall et al., Basel, Switzerland. In Embo Mol Med, Feb 2016
Restoration of glucose uptake in BAT by overexpression of hexokinase II or activated Akt2 was sufficient to increase body temperature and improve cold tolerance in AdRiKO mice.
Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase.
New
D'Antonio et al., United States. In Mol Biochem Parasitol, Feb 2016
UNASSIGNED: Glucokinase and hexokinase from pathogenic protozoa Trypanosoma cruzi are potential drug targets for antiparasitic chemotherapy of Chagas' disease.
Magnaporthe oryzae Aminosugar Metabolism is Essential for Successful Host Colonization.
New
Datta et al., New Delhi, India. In Environ Microbiol, Feb 2016
The catabolic pathway is composed of a GlcNAc transporter (MoNgt1), hexokinase(s), a GlcNAc-6-phosphate deacetylase (MoDac) and a GlcN-6-phosphate deaminase (MoDeam).
Role of hexokinase and VDAC in neurological disorders.
New
de Cerqueira César et al., Pirassununga, Brazil. In Curr Mol Pharmacol, Feb 2016
A key feature of brain bioenergetics is hexokinase (HK) binding to the outer mitochondrial membrane through the voltage dependent anion channel (VDAC).
An Integrated Circuit for Chip-Based Analysis of Enzyme Kinetics and Metabolite Quantification.
New
Cumming et al., In Ieee Trans Biomed Circuits Syst, Feb 2016
The device was then used to measure glucose concentration through the activity of hexokinase in the range of 0.05 mM-231 mM, encompassing glucose's physiological range in blood.
Mg++ requirement for MtHK binding, and Mg++ stabilization of mitochondrial membranes via activation of MtHK & MtCK activities and promotion of mitochondrial permeability transition pore closure: A hypothesis on mechanisms underlying Mg++'s antioxidant and cytoprotective effects.
Review
New
Golshani-Hebroni, In Gene, Jan 2016
The profound anti-apoptotic, anabolic, and anti-oxidant effects of mitochondrion bound hexokinase (MtHk), and the anti-apoptotic, anti-necrotic, and anti-oxidant functions of mitochondrial creatine kinase (MtCK) have been established over the past few decades.
Polyphenols as mitochondria-targeted anticancer drugs.
Review
New
Lewandowska et al., Łódź, Poland. In Cancer Lett, Nov 2015
(2013) according to their molecular mode of action into: hexokinase inhibitors; mimickers of the Bcl-2 homology-3 (BH3) domains; thiol redox inhibitors; deregulators of voltage-dependent anionic channel (VDAC)/adenine nucleotide translocase (ANT) complex; electron redox chain-targeting agents; lipophilic cations targeting the mitochondrial inner membrane; tricarboxylic acid cycle-targeting agents; and mitochondrial DNA-targeting agents.
Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy.
Review
Zhou et al., Tianjin, China. In Thorac Cancer, 2015
The three key enzymes of glycolysis are hexokinase, phosphofructokinase, and pyruvate kinase.
Dual proteolytic pathways govern glycolysis and immune competence.
Impact
Su et al., Bethesda, United States. In Cell, 2015
However, the overabundant lysosomes derange cellular metabolism by consuming the key glycolytic enzyme hexokinase-2 through chaperone-mediated autophagy.
HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection.
Review
Miyamoto et al., San Diego, United States. In Autophagy, 2014
HK2/hexokinase-II is a predominant isoform in insulin-sensitive tissues such as heart, skeletal muscle, and adipose tissues and is also upregulated in many types of tumors associated with enhanced aerobic glycolysis (the Warburg effect).
The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders.
Review
Wetzel et al., Regensburg, Germany. In Mini Rev Med Chem, 2014
Moreover, TSPO is interacting and building up functional complexes with other mitochondrial proteins such as the voltage-dependent anion channel (VDAC), the adenine nucleotide transporter (ANT), hexokinase I and II and Glycogen synthase kinase 3 beta (GSK3β).
Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: implications for brain energy metabolism and neurotrophic signaling.
GeneRIF
Fiskum et al., Baltimore, United States. In J Psychiatr Res, 2012
This study proposed that HK1 mitochondrial detachment could be linked to these disorders through impaired energy metabolism, increased vulnerability to oxidative stress, and impaired brain growth and development.
Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes.
GeneRIF
Pedersen et al., Copenhagen, Denmark. In Bmc Med Genet, 2010
An association is noted between the rs7072268 T-allele in HK1 and an increased blood glucose in non-diabetic individuals and a nominal association with type 2 diabetes prior to Bonferroni correction.
A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.
GeneRIF
Yu et al., Singapore, Singapore. In Mol Cell, 2010
FimA strengthens the VDAC1-hexokinase(I and II) interaction and prevents dissociation of hexokinase from VDAC1 triggered by apoptotic stimuli.
Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.
GeneRIF
De Felice et al., Rio de Janeiro, Brazil. In Plos One, 2009
Abeta-induced cellular redistribution and inactivation of neuronal HKI play important roles in oxidative stress and neurodegeneration in Alzheimer's disease
Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.
GeneRIF
Froguel et al., Lille, France. In Diabetes, 2009
HK1 may influence A1C levels through its anemic effect or its effect on glucose metabolism in erythrocytes, which may have implications for type 2 diabetes diagnosis and care.
Assessing the potential of glucokinase activators in diabetes therapy.
Review
Impact
Matschinsky, Philadelphia, United States. In Nat Rev Drug Discov, 2009
Glucokinase, a unique isoform of the hexokinase enzymes, which are known to phosphorylate D-glucose and other hexoses, was identified during the past three to four decades as a new, promising drug target for type 2 diabetes.
Nuclear pore association confers optimal expression levels for an inducible yeast gene.
Impact
Gasser et al., Basel, Switzerland. In Nature, 2006
Here we report that transcriptional activation of a subtelomeric gene, HXK1 (hexokinase isoenzyme 1), by growth on a non-glucose carbon source led to its relocalization to nuclear pores.
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
Impact
Yamada et al., Tsukuba, Japan. In Nat Med, 2006
TFE3 also induced hexokinase II (HK2) and insulin-induced gene 1 (INSIG1).
Sugar sensing and signaling in plants: conserved and novel mechanisms.
Review
Impact
Sheen et al., Leuven, Belgium. In Annu Rev Plant Biol, 2005
Genetic analyses have revealed extensive interactions between sugar and plant hormone signaling, and a central role for hexokinase (HXK) as a conserved glucose sensor.
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