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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Hematopoietically expressed homeobox

Hex, HHEX, PRH
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: N-acetyl-beta-D-glucosaminidase, CAN, ACID, HAD, fibrillin-1
Papers on Hex
The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth.
New
Oteiza et al., Stony Brook, United States. In Mol Carcinog, Feb 2016
Compared to the monomer ((-)-epicatechin) and the trimer, the hexamer (Hex) was the most active at reducing CRC cell viability.
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a.
New
McCormack et al., Australia. In Genes Dev, Feb 2016
Here we found that the hematopoietically expressed homeobox gene Hhex is overexpressed in acute myeloid leukemia (AML) and is essential for the initiation and propagation of MLL-ENL-induced AML but dispensable for normal myelopoiesis, indicating a specific requirement for Hhex for leukemic growth.
Screening of HHEX Mutations in Chinese Children with Thyroid Dysgenesis.
New
Deguo et al., In J Clin Res Pediatr Endocrinol, Jan 2016
The study was to screen Hematopoietically Expressed homeobox gene (HHEX) mutations in Chinese children with TD.
Hhex Is Necessary for the Hepatic Differentiation of Mouse ES Cells and Acts via Vegf Signaling.
New
Bogue et al., New Haven, United States. In Plos One, Dec 2015
We performed in vitro differentiation of mouse embryonic stem cells (mESCs) with a null mutation in the homeobox gene Hhex and show that Hhex-/- mESCs fail to differentiate from definitive endoderm (Sox17+/Foxa2+) to hepatic endoderm (Alb+/Dlk+).
Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice.
New
Kaestner et al., New Haven, United States. In Cell Mol Gastroenterol Hepatol, Oct 2015
We determine the role of the transcription factor hematopoietically expressed homeobox protein (Hhex) in ductal secretion and pancreatitis.
Genetics of neuroendocrine factors in rheumatoid arthritis.
Review
New
Imrich et al., Bratislava, Slovakia. In Horm Metab Res, Jun 2015
Recently, several new gene variants have been identified in association with serum DHEAS concentrations, such as in SULT2A1 and HHEX genes.
Thyroid transcription factors in development, differentiation and disease.
Review
Santisteban et al., Madrid, Spain. In Nat Rev Endocrinol, 2015
Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX, has considerably advanced our understanding of thyroid development, congenital thyroid disorders and thyroid cancer.
Calcisponges have a ParaHox gene and dynamic expression of dispersed NK homeobox genes.
Impact
Adamska et al., Bergen, Norway. In Nature, 2014
Our phylogenetic analyses demonstrate that these calcisponges possess orthologues of bilaterian NK genes (Hex, Hmx and Msx), a varying number of additional NK genes and one ParaHox gene, Cdx.
[Molecular pathogenesis and therapeutic approach of GM2 gangliosidosis].
Review
Tsuji, Tokushima, Japan. In Yakugaku Zasshi, 2012
Experimental and therapeutic approaches, including recombinant enzyme replacement, have been performed using Sandhoff disease model mice, suggesting the future application of novel techniques to treat GM2 gangliosidoses (Hex deficiencies), including Sandhoff disease as well as Tay-Sachs disease.
A potential role for the homeoprotein Hhex in hepatocellular carcinoma progression.
GeneRIF
Hu et al., Shanghai, China. In Med Oncol, 2012
Loss of HHEX is associated with colorectal cancer.
Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos.
GeneRIF
Chen et al., Guangzhou, China. In Proc Natl Acad Sci U S A, 2012
Data show that knockdown of hematopoietically expressed homeobox (hhex) resulted in a down-regulation of ventral pancreatic precursor 1 (vpp1) expression and a specific loss of the ventral pancreas.
[Association analysis of genetic polymorphisms of TCF7L2, CDKAL1, SLC30A8, HHEX genes and microvascular complications of type 2 diabetes mellitus].
GeneRIF
Yin et al., Chongqing, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
The associations between SNPs of TCF7L2, CDKAL1, SLC30A8 and HHEX and the development of DR and DN.
NKL homeobox genes in leukemia.
Review
Meijerink et al., Rotterdam, Netherlands. In Leukemia, 2012
We hypothesize that the NKL genes might share a similar downstream effect that promotes leukemogenesis, possibly due to mimicking a NKL gene that has a physiological role in early hematopoietic development, such as HHEX.
Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population.
GeneRIF
Shen et al., Nanjing, China. In Plos One, 2011
Genetic variants of the IDE-KIF11-HHEX region at 10q23.33 contribute to type 2 diabetes susceptibility.
The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation.
GeneRIF
Gaston et al., Birmingham, United Kingdom. In Plos One, 2011
The proline rich homeodomain protein PRH/Hhex forms predominantly octameric and/or hexadecameric species in solution as well as larger assemblies.
Structure-based analysis of the molecular recognitions between HIV-1 TAR-RNA and transcription factor nuclear factor-kappaB (NFkB).
Review
Gambari et al., Ferrara, Italy. In Curr Top Med Chem, 2011
In this paper we applied the "macromolecular docking" procedure to perform molecular modeling with the aim of screening transcription factor sequences for possible interaction to the HIV-1 TAR-RNA, employing the software Hex version 4.2.
Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?
Review
Impact
Schwartz et al., Philadelphia, United States. In Endocr Rev, 2010
For instance, no conclusive support for a role of the T1D-associated INS gene has been reported in T2D; conversely, but similarly, no evidence has been found for the role of the T2D-associated genes IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, FTO, and TCF7L2 in T1D.
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
Impact
Curtis et al., Melbourne, Australia. In Science, 2010
Forced expression of one such gene, Hhex, was sufficient to initiate self-renewal of thymocytes in vivo.
Anterior definitive endoderm from ESCs reveals a role for FGF signaling.
Impact
Brickman et al., Edinburgh, United Kingdom. In Cell Stem Cell, 2008
To address this, we devised a strategy using a fluorescent reporter gene under the transcriptional control of the anterior endoderm marker Hex alongside the definitive mesendoderm marker Cxcr4.
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Impact
Purcell et al., Cambridge, United States. In Science, 2007
With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study.
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