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Hairy and enhancer of split 7

Hes7
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (from NCBI)
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Top mentioned proteins: CLOCK, Lfng, galectin-1, CAN, Mesp2
Papers on Hes7
The transcriptome of utricle hair cell regeneration in the avian inner ear.
New
Lovett et al., Saint Louis, United States. In J Neurosci, 05 Apr 2014
For example, we show that HES7 is specifically expressed during utricle hair cell regeneration and closely parallels the expression of HES5.
3'-UTR-dependent regulation of mRNA turnover is critical for differential distribution patterns of cyclic gene mRNAs.
New
Bessho et al., Nara, Japan. In Febs J, Jan 2014
Somite segmentation, a prominent periodic event in the development of vertebrates, is instructed by cyclic expression of several genes, including Hes7 and Lunatic fringe (Lfng).
Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes.
New
Ish-Horowicz et al., London, United Kingdom. In Proc Natl Acad Sci U S A, Dec 2013
Here, we measure expression delays for three transcripts [Lunatic fringe, Hes7/her1, and Notch-regulated-ankyrin-repeat-protein (Nrarp)], that cycle during segmentation in the zebrafish, chick, and mouse, and provide in vivo measurements of endogenous splicing and export kinetics.
Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus.
New
Dunwoodie et al., Sydney, Australia. In Am J Med Genet A, Sep 2013
We found that both individuals were homozygous for the same mutation in HES7, and that this mutation caused a significant reduction of HES7 protein function; HES7 mutation causes SCD4.
Oscillatory links of Fgf signaling and Hes7 in the segmentation clock.
New
Kageyama et al., Kyoto, Japan. In Curr Opin Genet Dev, Aug 2013
Somitogenesis is controlled by the segmentation clock, where the oscillatory expression of cyclic genes such as Hes7 leads to the periodic expression of Mesp2, a master gene for somite formation.
Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6.
New
Dunwoodie et al., Sydney, Australia. In Hum Mol Genet, May 2013
Over the past decade, the genetic basis of several forms of autosomal recessive SCD cases has been solved with the identification of four causative genes (DLL3, MESP2, LFNG and HES7).
Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock.
Kageyama et al., Kyoto, Japan. In Plos One, 2012
A crucial component of the segmentation clock is the gene Hes7, which is regulated by the Notch and Fgf/Mapk pathways, but its relation to other pathways is unknown.
The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network.
Kudlicki et al., Galveston, United States. In Bmc Dev Biol, 2012
Our results also indicate the presence of a new class of genes (including Raf1 and Hes7) with two peaks of activity in two distinct phases of the somite cycle.
Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection.
Lackner et al., United States. In Plos One, 2012
In contrast, expression of NOTCH3, notch target genes (HES4, HES7) and EZH2 (histone methyltransferase) were significantly increased at 90DPI.
Oscillatory gene expression and somitogenesis.
Review
Harima et al., Kyoto, Japan. In Wiley Interdiscip Rev Dev Biol, 2012
Expression of her1 and her7 in zebrafish and Hes7 in mice oscillates by negative feedback, and mathematical models have been used to generate and test hypotheses to aide elucidation of the role of negative feedback in regulating oscillatory expression.
Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.
GeneRIF
Qiu et al., Nanjing, China. In Stud Health Technol Inform, 2011
MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Intronic delay is essential for oscillatory expression in the segmentation clock.
GeneRIF
Kageyama et al., Kyoto, Japan. In Proc Natl Acad Sci U S A, 2011
introns lead to an approximately 19-min delay in the Hes7 gene expression, and mathematical modeling suggested that without such a delay, Hes7 oscillations would be abolished
Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis.
GeneRIF
Dunwoodie et al., Sydney, Australia. In Eur J Hum Genet, 2010
Two new missense mutations in HES7 in a family with spondylocostal dysostosis.
Ultradian oscillations in Notch signaling regulate dynamic biological events.
Review
Ohtsuka et al., Kyoto, Japan. In Curr Top Dev Biol, 2009
This periodic event is regulated by a biological clock called the segmentation clock, which involves cyclic expression of the Notch effector gene Hes7.
The role of Notch in patterning the human vertebral column.
Review
Dunwoodie, Sydney, Australia. In Curr Opin Genet Dev, 2009
More specifically it describes that mutations in genes encoding Notch pathway components (DLL3, MESP2, LFNG and HES7) cause severe congenital vertebral defects in humans.
Rhythmic gene expression in somite formation and neural development.
Review
Shimojo et al., Kyoto, Japan. In Mol Cells, 2009
In mouse embryos, somite formation occurs every two hours, and this periodic event is regulated by a biological clock called the segmentation clock, which involves cyclic expression of the basic helix-loop-helix gene Hes7.
Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM.
GeneRIF
Bessho et al., Ikoma, Japan. In Plos One, 2008
Sprouty4 does not oscillate in Hes7-null mutant mouse embryos, and Hes7 can inhibit FGF-induced transcriptional activity of the Sprouty4 promoter.
Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis.
GeneRIF
Ish-Horowicz et al., London, United Kingdom. In Plos One, 2008
there are differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis
Mesp-family genes are required for segmental patterning and segmental border formation.
Review
Takahashi et al., Mishima, Japan. In Adv Exp Med Biol, 2007
In the posterior PSM, a basic-HLH protein Hes7 plays a central role to generate traveling wave of gene expression by negatively regulating the transcription of the target genes, which may lead defining soimte spacing and future segmental unit.
Instability of Hes7 protein is crucial for the somite segmentation clock.
Impact
GeneRIF
Kageyama et al., Kyoto, Japan. In Nat Genet, 2004
instability of Hes7 is essential for sustained oscillation and for its function as a segmentation clock
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