gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hairy and enhancer of split 6

Hes6, Her13.2
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: galectin-1, CAN, FATE, HES4, Rbx1
Papers using Hes6 antibodies
HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program
Supplier
St-Arnaud René et al., In The Journal of Cell Biology, 1995
... The HES6 cDNA, lacking the first 16 amino acids, was then subcloned into a yeast two-hybrid assay vector (pGAD-GH; CLONTECH Laboratories, Inc.) or mammalian ...
Papers on Hes6
Notch pathway promotes ovarian cancer growth and migration via CXCR4/SDF1α chemokine system.
New
Platonova et al., Milano, Italy. In Int J Biochem Cell Biol, Sep 2015
Additionally, for the first time, we demonstrated that Notch signalling activation can be detected in ovarian cancer specimens by immunohistochemistry analysis of the Notch transcriptional target, HES6 and is positively correlated with high expression levels of CXCR4 and SDF1α.
HES6 promotes prostate cancer aggressiveness independently of Notch signalling.
New
Berman et al., Baltimore, United States. In J Cell Mol Med, Jul 2015
We comprehensively profiled Notch pathway components in prostate cells and found prostate cancer-specific up-regulation of NOTCH3 and HES6.
HES5 silencing is an early and recurrent change in prostate tumourigenesis.
New
Lynch et al., Cambridge, United Kingdom. In Endocr Relat Cancer, Apr 2015
Treatment of prostate cancer cells with the demethylating agent 5-aza-2'-deoxycytidine increased HES5 expression and downregulated its transcriptional target HES6, consistent with functional silencing of the HES5 gene in prostate cancer.
Modeling the zebrafish segmentation clock's gene regulatory network constrained by expression data suggests evolutionary transitions between oscillating and nonoscillating transcription.
Holley et al., New Haven, United States. In Genetics, 2014
The nonoscillating gene hes6 forms the hub of a network of 10 Her/Hes protein dimers, which includes 7 DNA-binding dimers and 4 weak or non-DNA-binding dimers.
HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.
Neal et al., Cambridge, United Kingdom. In Embo Mol Med, 2014
HES6 is a transcription co-factor associated with stem cell characteristics in neural tissue.
Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia.
Plass et al., Heidelberg, Germany. In Genome Med, 2013
Nine novel hypermethylated genes, FZD5, FZD8, PRDM16, ROBO3, CXCL14, BCOR, ITPKA, HES6 and TAL1, the latter four being potential PU.1 targets, were confirmed to be hypermethylated in human normal karyotype AML patients, underscoring the relevance of the mouse model for human AML.
Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line.
Jaskula-Sztul et al., Madison, United States. In Cancer Med, 2013
Furthermore, treatment with thiocoraline resulted in changes in the expression of downstream targets of the Notch pathway (HES1, HES2, HES6, HEY1, and HEY2) and reduced expression of NET markers, CgA, and ASCL1.
Inferring the in vivo cellular program of developing bovine skeletal muscle from expression data.
Dalrymple et al., Australia. In Gene Expr Patterns, 2013
Of the canonical pro-myogenic transcription factors (TF), MYF6 and MYF5 are negatively co-expressed, with MYF6 displaying higher expression in the post-natal samples and MYF5, MYOG, HES6 and PAX7 displaying higher expression in early development.
HES6 enhances the motility of alveolar rhabdomyosarcoma cells.
Jones et al., Cambridge, United Kingdom. In Exp Cell Res, 2013
HES6, a member of the hairy-enhancer-of-split family of transcription factors, plays multiple roles in myogenesis.
Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6.
Cho et al., Seoul, South Korea. In Exp Mol Med, 2012
To test this possibility, human LDLR promoter reporter constructs were transfected into HepG2 cells and the effects of CLOCK/BMAL1, Hes1, and Hes6 expression were analyzed.
ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of nuclear factor-κB.
Demoulin et al., Brussels, Belgium. In Haematologica, 2012
In addition, several potential regulators of this process, including HES6, MYC and FOXO3 were identified using expression microarrays.
HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.
GeneRIF
Kallioniemi et al., Turku, Finland. In Oncogene, 2012
HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.
The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub.
GeneRIF
Holley et al., New Haven, United States. In Development, 2012
Data define a network of Her/Hes dimers underlying transcriptional negative feedback within the zebrafish segmentation clock, where Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6.
Topology and dynamics of the zebrafish segmentation clock core circuit.
Oates et al., Dresden, Germany. In Plos Biol, 2011
We show that the core pace-making circuit consists of two distinct negative feedback loops, one with Her1 homodimers and the other with Her7:Hes6 heterodimers, operating in parallel.
Activation of the Jak/Stat signalling pathway by leukaemia inhibitory factor stimulates trans-differentiation of human non-endocrine pancreatic cells into insulin-producing cells.
Saudek et al., Praha, Czech Republic. In Folia Biol (praha), 2011
Activation of the Jak/Stat signalling pathway by leukaemia inhibitory factor (LIF) stimulated differentiation of C-peptide-negative human non-endocrine pancreatic cells into insulin-producing cells in 6.3 ± 2.0 % cells (N = 5) and induced expression of pro-endocrine transcription factor neurogenin 3, Notch signalling pathway suppressor HES6 and stimulator of β-cell neogenesis REG3A.
Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development.
GeneRIF
Reh et al., Seattle, United States. In Dev Dyn, 2009
Data reveal a role for Ascl1 in the regulation of Hes6, a proneurogenic factor that inhibits Notch signaling to promote neural rather than glial differentiation
Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response.
GeneRIF
Kennedy et al., Christchurch, New Zealand. In Neurosci Lett, 2009
These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed.
Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation.
GeneRIF
Ström et al., Huddinge, Sweden. In Breast Cancer Res, 2008
Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells.
share on facebooktweetadd +1mail to friends