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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Hairy and enhancer of split 4

HES4, hHes4
Top mentioned proteins: galectin-1, Hes7, Hes6, Rbx1, ACID
Papers on HES4
Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition.
New
Raabe et al., Bethesda, United States. In J Neuropathol Exp Neurol, Aug 2015
Treatment of the DIPG cell lines JHH-DIPG1 and SF7761 with the γ-secretase inhibitor MRK003 suppressed the level of the NOTCH effectors HES1, HES4, and HES5; inhibited DIPG growth by 75%; and caused a 3-fold induction of apoptosis.
Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains.
New
Chen et al., Baltimore, United States. In Hum Mol Genet, Apr 2015
Neuron-specific mapping of the genome-wide distribution of H3K4me3 revealed 136 differentially enriched loci associated with genes implicated in neuronal development and neurodegeneration, including GPR3, TMEM106B, PDIA6 and the Notch signaling genes hairy and enhancer of split 4 (HES4) and JAGGED2, supporting the view that the neuronal epigenome is affected in HD.
A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.
LoRusso et al., Milano, Italy. In Clin Cancer Res, 2015
Consistent downmodulation of NOTCH-related HES4 gene expression was observed in peripheral blood from all evaluable patients.
Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.
Sathyanarayanan et al., Boston, United States. In Cancer Discov, 2014
Immunohistochemical staining of N1-ICD in TNBC xenografts correlated with responsiveness, and expression levels of the direct Notch target gene HES4 correlated with outcome in patients with TNBC.
Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection.
Lackner et al., United States. In Plos One, 2012
In contrast, expression of NOTCH3, notch target genes (HES4, HES7) and EZH2 (histone methyltransferase) were significantly increased at 90DPI.
Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models.
Christensen et al., Los Angeles, United States. In Clin Cancer Res, 2012
In the tested breast xenograft models, the baseline expressions of the Notch receptors, ligands, and the cleaved Notch1 failed to predict the antitumor response to PF-03084014, whereas several Notch pathway target genes, including HEY2, HES4, and HES3, strongly corresponded with the response with a P value less than 0.01.
Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines.
MacLeod et al., Braunschweig, Germany. In Leuk Res, 2010
Differential expression was detected for BHLHB2, HES1, HES4, HEY1, ID1, ID2, ID3, LYL1 and TAL1, highlighting dysregulation of family members with inhibitory activity.
[In vitro activity of human bone marrow cells after cryopreservation in liquid nitrogen for 21 - 25 years].
Zhao et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010
The method of freezing by -80 degrees C refrigerator with 5% DMSO-6% HES-4% HuA and preserving in liquid nitrogen would be convenient, cheap and easily-manipulated for preservation of the human bone marrow cells.
Comparative evaluation of different in vitro systems that stimulate germ cell differentiation in human embryonic stem cells.
Bongso et al., Singapore, Singapore. In Fertil Steril, 2010
RESULT(S): Expression data for both HES-3 and HES-4 differentiating cultures strongly indicated that inactivated POFs encouraged differentiation of hESC EBs into a germ cell lineage.
Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies.
Stroncek et al., Bethesda, United States. In J Transl Med, 2009
The expression of classical mDC biomarker genes CD83, CCR7, CCL5, CCL8, SOD2, MT2A, OASL, GBP1 and HES4 were up-regulated throughout maturation while MTIB, MTIE, MTIG, MTIH, GADD45A and LAMP3 were only up-regulated late in maturation.
Separation of SSEA-4 and TRA-1-60 labelled undifferentiated human embryonic stem cells from a heterogeneous cell population using magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS).
Bongso et al., Singapore, Singapore. In Stem Cell Rev, 2009
HES-3 and HES-4 cells were labelled in separate experiments for the stem cell markers SSEA-4 and TRA-1-60 using primary antibodies.
Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer.
Katoh et al., Japan. In Int J Oncol, 2007
Refined phylogenetic analysis using HES3 variant 2 instead of variant 1 revealed that mammalian bHLH transcription factors with Orange domain were grouped into HES subfamily (HES1, HES2, HES3, HES4, HES5, HES6, HES7) and HEY subfamily (HEY1, HEY2, HEYL, HESL/HELT, DEC1/BHLHB2, DEC2/BHLHB3).
Cell surface 5T4 antigen is transiently upregulated during early human embryonic stem cell differentiation: effect of 5T4 phenotype on neural lineage formation.
Stern et al., Manchester, United Kingdom. In Exp Cell Res, 2006
We show that 5T4 antigen is transiently unregulated during HES4 and H1 human ES cell differentiation and its expression correlates with loss of the pluripotent markers OCT-4 and Tra-1-60 and upregulation of transcript markers associated with the three primary germ layers.
Comparative genomics on HHIP family orthologs.
Katoh et al., Japan. In Int J Mol Med, 2006
Expression of HES/HEY family members, including HES1, HES2, HES3, HES4, HES5, HES6, HES7, HEY1, HEY2 and HEYL, in coronary artery endothelial cells was not detected in silico.
Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures.
Mummery et al., Utrecht, Netherlands. In Stem Cells, 2005
The stimulating effect of serum-free coculture on cardiomyocyte differentiation was observed not only in HES-2 but also in the HES-3 and HES-4 cell lines.
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