Getting to the heart of hERG K(+) channel gating.
Australia. In J Physiol, Jul 2015
Potassium ion channels encoded by the human ether-a-go-go related gene (hERG) form the ion-conducting subunit of the rapid delayed rectifier potassium current (IKr ).
Efficacy and safety of prucalopride in adults and children with chronic constipation.
Amsterdam, Netherlands. In Expert Opin Pharmacother, Feb 2015
AREAS COVERED: A PubMed search (1965 - 2014) using the following terms alone or in combination: prucalopride, 5-HT4, R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, human ether-a-go-go related gene (hERG), arrhythmia, potassium current, elderly, children.
The structural mechanism of KCNH-channel regulation by the eag domain.
Seattle, United States. In Nature, 2013
The KCNH voltage-dependent potassium channels (ether-à-go-go, EAG; EAG-related gene, ERG; EAG-like channels, ELK) are important regulators of cellular excitability and have key roles in diseases such as cardiac long QT syndrome type 2 (LQT2), epilepsy, schizophrenia and cancer.