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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hect domain and RLD 6

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ISG15, Ubiquitin, RCC1, UBE1L, CAN
Papers on HerC6
Transcriptomic analysis by RNA sequencing reveals that hepatic interferon-induced genes may be associated with feed efficiency in beef heifers.
Fitzsimmons et al., In J Anim Sci, Jul 2015
Through a combination of whole transcriptome and candidate gene analyses, we identified differentially expressed genes involved in inflammatory processes including hemoglobin β (HBB), myxovirus resistance 1 interferon-inducible protein p78 (MX1), ISG15 ubiquitin-like modifier (ISG15), hect domain and RLD 6 (HERC6), and interferon-induced protein 44 (IFI44) whose mRNA abundance was lower (HBB) or higher (MX1, ISG15, HERC6, and IFI44) in low-RFIfat heifers.
Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles.
Shimotohno et al., San Diego, United States. In J Interferon Cytokine Res, May 2015
Recent in vitro studies revealed that human Herc5 and mouse Herc6 are major ISG15 E3 ligases, respectively.
Global gene expression profiling of monocyte-derived macrophages from red deer (Cervus elaphus) genotypically resistant or susceptible to Mycobacterium avium subspecies paratuberculosis infection.
Griffin et al., Dunedin, New Zealand. In Dev Comp Immunol, 2013
Highly upregulated genes were related to chemotaxis (CXCL10, CSF3, and CCL8) and type 1 interferon signalling (RSAD2, IFIT1, IFIT2, ISG12, ISG15, USP18, and HERC6).
Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau.
Evans et al., Dublin, Ireland. In Physiol Genomics, 2012
Quantitative real-time PCR analysis of selected genes revealed PARP12, ZNFX1, HERC6, IFI16, RNF213, and DDX58 expression increased in pregnant compared with cyclic endometria on day 16 and were directly upregulated by intrauterine infusion of IFNT in vivo for 2 h (P < 0.05).
HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells.
Versteeg et al., New York City, United States. In Plos One, 2011
HECT domain and RCC1-like domain containing protein 5 (HerC5) mediates global ISGylation in human cells, whereas its closest relative, HerC6, does not.
ISG15 modulates development of the erythroid lineage.
Quang et al., Orsay, France. In Plos One, 2010
Using both in vivo and in vitro differentiating erythroblasts, we show that expression of ISG15 as well as the ISGylation process related enzymes Ube1L, UbcM8 and Herc6 are induced during erythroid differentiation.
Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein.
García-Sastre et al., New York City, United States. In J Virol, 2010
We confirm that human HerC5, but not human HerC6, has ISG15 E3 ligase activity and identify mouse HerC6 as a bona fide ISG15 E3 ligase.
Proteomic characterization of differentially expressed proteins associated with no stress in retinal ganglion cells.
Lee et al., Asan, South Korea. In Bmb Rep, 2009
The increased GAPDH expression in response to GSNO treatment was accompanied by an increase in Herc6 protein, an E3 ubiquitin ligase.
The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.
Kroismayr et al., Vienna, Austria. In Genomics, 2005
HERC6 ancestor emerged in nematodes and that the family expanded throughout evolution. The mRNA expression pattern was found to be diverse in selected tissues and cells
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