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Cell division cycle associated 4

Hepp, CDCA4
This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: Galp, fibrillin-1, ESI, ACID, HAD
Papers on Hepp
Differential expression of microRNAs in 2-cell and 4-cell mouse embryos.
Ling et al., Nanjing, China. In Zygote, 2014
Cdca4 and Tcf12 were identified as miR-154 target genes by target prediction analysis.
The first example of the Fischer-Hepp type rearrangement in pyrimidines.
Jakubkiene et al., Vilnius, Lithuania. In Beilstein J Org Chem, 2012
The subsequent treatment of the obtained products with aq H2SO4 can lead to either N-denitrosation to obtain 4,6-pyrimidinediamines or to a Fischer-Hepp type rearrangement to obtain 5-nitroso-4,6-pyrimidinediamines.
The structural diversity of lipopolysaccharide expressed by non-typeable Haemophilus influenzae strains 1158 and 1159.
Schweda et al., Huddinge, Sweden. In Carbohydr Res, 2012
The most abundant glycoform contained a disaccharide chain: PCho→7)-D-α-D-Hepp-(1→6)-β-D-Glcp linked to HepI from the common structural element of H. influenzae LPS: L-α-D-HepIIIp-(1→2)-[PEtn→6]-L-α-D-HepIIp-(1→3)-L-α-D-HepIp-(1→5)-[PPEtn→4]-α-Kdop-(2→6)-lipid A. Phosphocholine (PCho) was found at two positions in the LPS glycoforms; PCho substituted the 6-position of β-D-Glcp attached to HepIII and was also located at a novel position linked to D-α-D-Hepp; this latter position was determined by structural analysis of LPS from a 1158lpsA mutant strain.
Structural studies of the lipopolysaccharide from Haemophilus parainfluenzae strain 20.
Schweda et al., Huddinge, Sweden. In Carbohydr Res, 2011
This sugar is in β-configuration when linked to O-4 of the glucose residue of β-D-Galp-(1→2)-L-α-D-Hepp-(1→2)-[PEtn→6]-L-α-D-Hepp-(1→3)-[β-D-Glcp-(1→4)]-L-α-D-Hepp-(1→5)-[PPEtn→4]-α-Kdo-(2→6)-lipid A. LPS from a wbaP mutant of H. parainfluenzae strain 20 did not contain an O-antigen, consistent with the wbaP gene product being required for expression of O-antigen in fully extended LPS.
Expression of a new disialyllacto structure in the lipopolysaccharide of non-typeable Haemophilus influenzae.
Schweda et al., Huddinge, Sweden. In Carbohydr Res, 2011
Both strains express the conserved triheptosyl inner core, [l-α-d-Hepp-(1→2)-[PEtn→6]-l-α-d-Hepp-(1→3)-l-α-d-Hepp-(1→5)-[PPEtn→4]-α-Kdo-(2→6)-Lipid A] with PCho→6)-β-d-Glcp (GlcI) substituting the proximal heptose (HepI) at O-4. Strain 1247 expresses the common structural motifs of H. influenzae; globotetraose [β-d-GalpNAc-(1→3)-α-d-Galp-(1→4)-β-d-Galp-(1→4)-β-d-Glcp-(1→] and its truncated versions globoside [α-d-Galp-(1→4)-β-d-Galp-(1→4)-β-d-Glcp-(1→] and lactose [β-d-Galp-(1→4)-β-d-Glcp-(1→] linked to the terminal heptose of the inner core and GlcI.
Detailed structural features of lipopolysaccharide glycoforms in nontypeable Haemophilus influenzae strain 2019.
Schweda et al., Huddinge, Sweden. In Carbohydr Res, 2011
Analysis of LPS from wild type and lex2B, lpt3 and pgm mutant strains using NMR techniques and ESI-MS on O-deacylated LPS and core oligosaccharide material (OS), as well as ESI-MS(n) on permethylated dephosphorylated OS, confirmed the previously established structure in which lactose is linked to the proximal heptose (HepI) of the conserved triheptosyl inner-core moiety, l-α-D-Hepp-(1→2)-[PEtn→6]-l-α-D-Hepp-(1→3)-l-α-D-Hepp-(1→5)-[PPEtn→4]-α-Kdo-(2→6)-lipid A. Importantly, our data provide further structural detail whereby extensions from the middle heptose (HepII) are now characterized as β-D-Galp-(1→4)-β-D-Glcp-(1→4)-α-D-Glcp-(1→3 and truncated versions thereof.
The role of lic2B in lipopolysaccharide biosynthesis in Haemophilus influenzae strain Eagan.
Schweda et al., Huddinge, Sweden. In Carbohydr Res, 2011
Lic2B was found to encode a glucosyltransferase responsible for the linkage of β-D-Glcp-(1→4)-α-D-Glcp-(1→ extending from O-3 of the central heptose of the triheptosyl inner-core moiety, l-α-D-Hepp-(1→2)-[PEtn→6]-l-α-D-Hepp-(1→3)-l-α-D-Hepp-(1→5)-[PPEtn→4]-α-Kdo-(2→6)-lipid A.
Vasorelaxant and hypotensive effects of the extract and the isolated flavonoid rutin obtained from Polygala paniculata L.
Santos et al., Curitiba, Brazil. In J Pharm Pharmacol, 2011
OBJECTIVES: This study aimed to investigate the in-vitro and in-vivo cardiovascular effects of the crude hydroalcoholic extract from Polygala paniculata (HEPP) in rats.
A dual role for the lex2 locus: identification of galactosyltransferase activity in non-typeable Haemophilus influenzae strains 1124 and 2019.
Schweda et al., Huddinge, Sweden. In Carbohydr Res, 2009
Lipopolysaccharide (LPS) of Haemophilus influenzae comprises a conserved tri-l-glycero-d-manno-heptosyl inner-core moiety (l-alpha-d-Hepp-(1-->2)-[PEtn-->6]-l-alpha-d-Hepp-(1-->3)-[beta-d-GlcIp-(1-->4)]-l-alpha-d-Hepp-(1-->5)-alpha-Kdop) to which addition of beta-d-Glcp to O-4 of GlcI in serotype b strains is controlled by the gene lex2B.
Transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression.
GeneRIF
Yoshida et al., Kawasaki, Japan. In Biochimie, 2008
an important role of CDCA4 in the context of transcriptional regulation and cell fate determination through the JUN oncogene
The spindle function of CDCA4.
GeneRIF
Zeng et al., Beijing, China. In Cell Motil Cytoskeleton, 2008
Data suggest that CDCA4 is involved in spindle organization from prometaphase, and when anaphase begins, it may play a different role as a midzone factor involved in chromosome segregation or cytokinesis.
Reversal of GABA-mediated inhibition of the electrically and potassium chloride evoked [3H]-GABA release from rat substantia nigra slices by DL-3-hydroxy-3-phenyl pentanamide.
Bowery et al., Mexico. In Arzneimittelforschung, 2007
The phenyl alcohol amides, DL-2-hydroxy-2-phenyl butyramide (CAS 52839-87-9), DL-3-hydroxy-3-phenyl pentanamide (CAS 131802-69-2, DL-HEPP) and DL-4-hydroxy-4-phenyl hexanamide (CAS 67880-30-2) and their fluorine and chlorine analogs, at a concentration of 100 micromol/L, did not displace [3H]-gamma-aminobutyric acid ([3H]-GABA, CAS 108158-36-7) from GABAA receptors and only weakly displaced [3H]-GABA and [3H]-CGP62349 (CAS 186986-97-0), a GABAB receptor antagonist, from GABAB receptors in rat brain crude synaptic membranes.
Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence.
Review
Moxon et al., Huddinge, Sweden. In Int J Med Microbiol, 2007
LPS from H. influenzae consists of a conserved glucose-substituted triheptosyl inner-core moiety l-alpha-d-Hepp-(1-->2)-[PEtn-->6]-l-alpha-d-Hepp-(1-->3)-[beta-d-Glcp-(1-->4)]-l-alpha-d-Hepp linked to lipid A via Kdo 4-phosphate.
Neutralizing and cross-reactive antibodies against enterobacterial lipopolysaccharide.
Review
Brade et al., Germany. In Int J Med Microbiol, 2007
The minimal structural element necessary for high-affinity binding consists of R(1)-alpha-d-Glcp-(1-->3)-[l-alpha-d-Hepp-(1-->7)]-l-alpha-d-Hepp 4P-(1-->3)-R(2) (R(1), R(2)=additional sugars of LPS) in which the side-chain heptose and the 4-phosphate on the branched heptose are the main determinants of the epitope.
CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation.
GeneRIF
Yoshida et al., Kawasaki, Japan. In J Biol Chem, 2006
CDCA4 participates in the regulation of cell proliferation, mainly through the E2F/retinoblastoma protein pathway
Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP).
GeneRIF
Wicking et al., Australia. In Gene, 2006
The evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein Cdca4 was studied.
Cloning and characterization of Hepp, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells.
GeneRIF
Jurecic et al., Miami, United States. In Blood Cells Mol Dis, 2001
Isolation of the mouse ortholog and comparison to the human protein.
Therapeutic options in ocular allergic disease.
Review
Lightman et al., London, United Kingdom. In Drugs, 1995
Although results with HEPP have been disappointing, other modulators of mast cell function (e.g.
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