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Hepcidin antimicrobial peptide

Hepcidin, hepcidin-25
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Transferrin, Interleukin-6, CAN, HAD, HFE
Papers on Hepcidin
Defensive response of European sea bass (Dicentrarchus labrax) against Listonella anguillarum or Photobacterium damselae subsp. piscicida experimental infection.
New
Tiscar et al., Teramo, Italy. In Vet Immunol Immunopathol, 15 Jan 2015
At 24 and 72h post-infection, the expression analysis of immune-relevant genes (IL-1β, IL-6, IL-8, Hepcidin), the transcriptional level and detection of HSP70, and the quantification of serum iron were investigated in association with the histological analysis and the bacterial recognition in tissues by immunohistochemistry.
Recent Advances in Iron Metabolism: Relevance for Health, Exercise, and Performance.
New
Recalcati et al., Milano, Italy. In Med Sci Sports Exerc, 09 Jan 2015
Hepcidin is the central regulator of systemic iron homeostasis and exerts its function by controlling the presence of the iron exporter ferroportin on the cell membrane.
Serum hepcidin-25 level linked with high mortality in patients with non-Hodgkin lymphoma.
New
Nitta et al., Tokyo, Japan. In Ann Hematol, 03 Jan 2015
UNLABELLED: Hepatic hepcidin-25 production is stimulated by systemic inflammation, and it interferes with the body's utilization of iron, leading to anemia.
Hepcidin Expression in Psoriasis Patients.
New
Saral et al., Rize, Turkey. In Indian J Dermatol, 30 Nov 2014
Hepcidin is an important and recently discovered regulator of iron homeostasis.
Iron metabolism in hamsters experimentally infected with Leptospira interrogans serovar Pomona: Influence on disease pathogenesis.
New
Leal et al., Santa Maria, Brazil. In Comp Immunol Microbiol Infect Dis, 08 Nov 2014
Additionally, the total antioxidant capacity (TAC) and total oxidant status (TOS) were assessed, along with hepcidin and IL-6 levels.
The iron-regulatory hormone hepcidin: A possible therapeutic target?
Review
New
Vergely et al., Dijon, France. In Pharmacol Ther, Oct 2014
Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis.
Mechanistic and regulatory aspects of intestinal iron absorption.
Review
New
Collins et al., Brisbane, Australia. In Am J Physiol Gastrointest Liver Physiol, Sep 2014
Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin.
Iron, anemia and hepcidin in malaria.
Review
New
Drakesmith et al., Bethesda, United States. In Front Pharmacol, Dec 2013
Key to understanding the pathophysiology of iron metabolism in malaria is the activity of the iron regulatory hormone hepcidin.
Hepcidin antagonists for potential treatments of disorders with hepcidin excess.
Review
New
Arosio et al., Brescia, Italy. In Front Pharmacol, Dec 2013
The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis.
The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract.
Review
New
Zekanowska et al., Bydgoszcz, Poland. In Prz Gastroenterol, Dec 2013
Hepcidin, a 25-amino acid polypeptide, which is synthesised primarily in hepatocytes, reduces the iron absorption from the intestine by binding to the only known cellular iron exporter, ferroportin, causing it to be degraded.
Systemic iron homeostasis.
Review
New
Impact
Ganz, In Physiol Rev, Oct 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
Hepcidin and the iron-infection axis.
Review
Impact
Prentice et al., Oxford, United Kingdom. In Science, 2012
Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
GeneRIF
Guo et al., Shanghai, China. In Febs J, 2012
labeled hepcidin was also a suitable tool to visualize internalization of overexpressed or even endogenously expressed ferroportin without tags
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
GeneRIF
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Impact
GeneRIF
Arvedson et al., Thousand Oaks, United States. In Cell Metab, 2012
Hepcidin-induced ferroportin internalization did not require JAK2 or phosphorylation of ferroportin residues 302 and 303
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.
Impact
GeneRIF
Nemeth et al., Los Angeles, United States. In Cell Metab, 2012
ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis
[Hepcidin and diabetic anemia: is there an association?].
GeneRIF
Elias et al., Israel. In Harefuah, 2012
Based on the results of this small study, hepcidin was not associated with diabetic anemia
Intestinal ferritin H is required for an accurate control of iron absorption.
Impact
Kühn et al., Lausanne, Switzerland. In Cell Metab, 2010
To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.
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