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Hepcidin antimicrobial peptide

Hepcidin, hepcidin-25
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Transferrin, Interleukin-6, CAN, HAD, fibrillin-1
Papers on Hepcidin
Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency - a prospective cohort study.
Szecsi et al., Copenhagen, Denmark. In J Matern Fetal Neonatal Med, 27 Aug 2015
OBJECTIVE: To investigate hepcidin during pregnancy, delivery and postpartum in women with sufficient iron supplementation.
Homeostasis of Iron and Hepcidin in Erythropoietic Protoporphyria [EPP].
Bonkovsky et al., Charlotte, United States. In Eur J Clin Invest, 21 Aug 2015
Our aim was to determine whether hepcidin is increased in EPP/XLPP patients, resulting in decreased enteral iron absorption and IDA.
Starvation beneficially influences the liver physiology and nutrient metabolism in Edwardsiella tarda infected red sea bream (Pagrus major).
Ohta et al., Japan. In Comp Biochem Physiol A Mol Integr Physiol, 15 Aug 2015
The transcription of several iron homeostatis related genes, Hepcidin 1 and Transferrin, initially increased in 0dai (days after infection) starved fish but reduced significantly (P<0.05) at later stages.
Expression and purification of a new recombinant camel hepcidin able to promote the degradation of the iron exporter ferroportin1.
Sari et al., Tunisia. In Protein Expr Purif, 11 Aug 2015
UNASSIGNED: Hepcidin, a 25-amino-acid and highly disulfide bonded antimicrobial peptide, is the central regulator of iron homeostasis.
Serum hepcidin concentrations and type 2 diabetes.
Tuomainen et al., Kuopio, Finland. In World J Diabetes, 10 Aug 2015
Hepcidin is a peptide hormone with both paracrine and endocrine functions that help in maintaining body iron stores.
Systemic inflammation up-regulates serum hepcidin in exacerbations and stabile chronic obstructive pulmonary disease.
Salamunic et al., Split, Croatia. In Clin Biochem, 08 Aug 2015
OBJECTIVES: Hepcidin is the main regulator of systemic iron homeostasis and its expression is modulated by iron status, hypoxia, erythroid factors and inflammation.
Hepcidin - A novel biomarker with changing trends.
Seetharam et al., Pondicherry, India. In Pharmacogn Rev, Jan 2015
Hepcidin is a novel peptide hormone of hepatic origin.
Hepcidin: regulation of the master iron regulator.
Subramaniam et al., Brisbane, Australia. In Biosci Rep, Dec 2014
This regulation is mediated by the iron-regulatory hormone hepcidin.
Anemia in inflammatory bowel disease: an under-estimated problem?
Vavricka et al., Zürich, Switzerland. In Front Med (lausanne), 2013
Hepcidin has been identified to be a central regulator of iron absorption from the intestine and of iron plasma levels.
The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract.
Zekanowska et al., Bydgoszcz, Poland. In Prz Gastroenterol, 2013
Hepcidin, a 25-amino acid polypeptide, which is synthesised primarily in hepatocytes, reduces the iron absorption from the intestine by binding to the only known cellular iron exporter, ferroportin, causing it to be degraded.
Systemic iron homeostasis.
Ganz, In Physiol Rev, 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
Hepcidin and the iron-infection axis.
Prentice et al., Oxford, United Kingdom. In Science, 2012
Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
Guo et al., Shanghai, China. In Febs J, 2012
labeled hepcidin was also a suitable tool to visualize internalization of overexpressed or even endogenously expressed ferroportin without tags
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Arvedson et al., Thousand Oaks, United States. In Cell Metab, 2012
Hepcidin-induced ferroportin internalization did not require JAK2 or phosphorylation of ferroportin residues 302 and 303
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.
Nemeth et al., Los Angeles, United States. In Cell Metab, 2012
ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis
[Hepcidin and diabetic anemia: is there an association?].
Elias et al., Israel. In Harefuah, 2012
Based on the results of this small study, hepcidin was not associated with diabetic anemia
Intestinal ferritin H is required for an accurate control of iron absorption.
Kühn et al., Lausanne, Switzerland. In Cell Metab, 2010
To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.
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