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Hepcidin antimicrobial peptide

Hepcidin, hepcidin-25
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Transferrin, Interleukin-6, CAN, HAD, fibrillin-1
Papers on Hepcidin
Hepcidin regulation in prostate and its disruption in prostate cancer.
New
Torti et al., Van, Turkey. In Cancer Res, 09 May 2015
UNASSIGNED: Hepcidin is a circulating peptide hormone made by the liver that is a central regulator of systemic iron uptake and recycling.
Hepcidin: Regulation of the master iron regulator.
New
Subramaniam et al., In Biosci Rep, 01 May 2015
This regulation is mediated by the iron-regulatory hormone hepcidin.
B-cell translocation gene 2 promotes hepatic hepcidin production via induction of Yin Yang 1.
New
Kim et al., Taegu, South Korea. In Biochem Biophys Res Commun, 01 May 2015
UNASSIGNED: Hepcidin is a peptide hormone secreted in the liver and plays a key role in maintaining iron homeostasis.
Peripheral expression of hepcidin gene in Egyptian β-thalassemia Major.
New
El-Samie et al., Cairo, Egypt. In Gene, 25 Apr 2015
There is a sophisticated balance of body iron metabolism of storage and transport which is regulated by several factors including the peptide hepcidin.
Hepcidin in chronic kidney disease: not an anaemia management tool, but promising as a cardiovascular biomarker.
New
Gaillard et al., Amsterdam, Netherlands. In Neth J Med, 31 Mar 2015
Hepcidin is a key regulator of iron homeostasis and plays a role in the pathogenesis of anaemia of chronic disease.
Mechanistic and regulatory aspects of intestinal iron absorption.
Review
New
Collins et al., Brisbane, Australia. In Am J Physiol Gastrointest Liver Physiol, Sep 2014
Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin.
Hepcidin and iron homeostasis during pregnancy.
Review
New
Nemeth et al., Chicago, United States. In Nutrients, Aug 2014
Hepcidin is the master regulator of systemic iron bioavailability in humans.
The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract.
Review
Zekanowska et al., Bydgoszcz, Poland. In Prz Gastroenterol, 2013
Hepcidin, a 25-amino acid polypeptide, which is synthesised primarily in hepatocytes, reduces the iron absorption from the intestine by binding to the only known cellular iron exporter, ferroportin, causing it to be degraded.
[The role of hepcidin in iron metabolism in inflammatory bowel diseases].
Review
Pac-Kozuchowska et al., In Postepy Hig Med Dosw (online), 2013
Hepcidin is a 25-amino-acid peptide synthesized predominantly in hepatocytes, which plays an essential role in the regulation of systemic iron homeostasis.
Anemia in inflammatory bowel disease: an under-estimated problem?
Review
Vavricka et al., Zürich, Switzerland. In Front Med (lausanne), 2013
Hepcidin has been identified to be a central regulator of iron absorption from the intestine and of iron plasma levels.
Systemic iron homeostasis.
Review
Impact
Ganz, In Physiol Rev, 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
Hepcidin and the iron-infection axis.
Review
Impact
Prentice et al., Oxford, United Kingdom. In Science, 2012
Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
GeneRIF
Guo et al., Shanghai, China. In Febs J, 2012
labeled hepcidin was also a suitable tool to visualize internalization of overexpressed or even endogenously expressed ferroportin without tags
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
GeneRIF
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Impact
GeneRIF
Arvedson et al., Thousand Oaks, United States. In Cell Metab, 2012
Hepcidin-induced ferroportin internalization did not require JAK2 or phosphorylation of ferroportin residues 302 and 303
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.
Impact
GeneRIF
Nemeth et al., Los Angeles, United States. In Cell Metab, 2012
ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis
[Hepcidin and diabetic anemia: is there an association?].
GeneRIF
Elias et al., Israel. In Harefuah, 2012
Based on the results of this small study, hepcidin was not associated with diabetic anemia
Intestinal ferritin H is required for an accurate control of iron absorption.
Impact
Kühn et al., Lausanne, Switzerland. In Cell Metab, 2010
To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.
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