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Hepcidin antimicrobial peptide

Hepcidin, hepcidin-25
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Transferrin, Interleukin-6, CAN, HAD, fibrillin-1
Papers on Hepcidin
Inflammation neither increases hepatic hepcidin nor affects intestinal (59)Fe-absorption in two murine models of bowel inflammation, hemizygous TNF(ΔARE/+) and homozygous IL-10(-/-) mice.
New
Schümann et al., München, Germany. In J Trace Elem Med Biol, 31 Oct 2015
Hepcidin-synthesis was reported to be stimulated by inflammation.
Impaired Hepcidin Expression in Alpha-1-Antitrypsin Deficiency Associated with Iron Overload and Progressive Liver Disease.
New
Zoller et al., Innsbruck, Austria. In Hum Mol Genet, 26 Sep 2015
The aim of the present study was to define the genetics of this correlation and the effect of alpha-1-antitrypsin on the expression of the iron hormone hepcidin.
Short-Term Effects of Blood Transfusions on Hepcidin in Preterm Infants.
New
Franz et al., Tübingen, Germany. In Neonatology, 19 Sep 2015
BACKGROUND: Hepcidin, a key regulatory peptide hormone in iron homeostasis, may in future serve as a non-invasive iron status parameter for monitoring iron supplementation in preterm infants.
Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation.
Review
New
Schmidt, Boston, United States. In J Biol Chem, 31 Aug 2015
Hepcidin, a molecule first characterized as an antimicrobial peptide, plays a critical role in the regulation of iron homeostasis.
Hepcidin and Host Defense against Infectious Diseases.
Review
New
Mehrad et al., Charlottesville, United States. In Plos Pathog, 31 Aug 2015
Hepcidin is the master regulator of iron homeostasis in vertebrates.
Serum hepcidin concentrations and type 2 diabetes.
Review
New
Tuomainen et al., Kuopio, Finland. In World J Diabetes, 10 Aug 2015
Hepcidin is a peptide hormone with both paracrine and endocrine functions that help in maintaining body iron stores.
Study of Serum Hepcidin as a Potential Mediator of the Disrupted Iron Metabolism in Obese Adolescents.
New
Moustafa et al., Cairo, Egypt. In Int J Health Sci (qassim), Apr 2015
We aimed to study the relation between serum hepcidin level and both iron as well as high sensitive CRP status in obese adolescents.
Hepcidin - A novel biomarker with changing trends.
Review
New
Seetharam et al., Pondicherry, India. In Pharmacogn Rev, Jan 2015
Hepcidin is a novel peptide hormone of hepatic origin.
Hepcidin: regulation of the master iron regulator.
Review
New
Subramaniam et al., Brisbane, Australia. In Biosci Rep, Dec 2014
This regulation is mediated by the iron-regulatory hormone hepcidin.
Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25.
New
Bossi et al., Verona, Italy. In J Nanobiotechnology, Dec 2014
FINDINGS: Morphological analysis showed MIP NPs of 20-50 nm; MIP NP exhibited high affinity and selectivity for the target analyte: low nanomolar Kds for the interaction NP/Hepcidin-25, but none for the NP/non regulative Hepcidin-20.
Systemic iron homeostasis.
Review
Impact
Ganz, In Physiol Rev, 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
Hepcidin and the iron-infection axis.
Review
Impact
Prentice et al., Oxford, United Kingdom. In Science, 2012
Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
GeneRIF
Guo et al., Shanghai, China. In Febs J, 2012
labeled hepcidin was also a suitable tool to visualize internalization of overexpressed or even endogenously expressed ferroportin without tags
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
GeneRIF
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Impact
GeneRIF
Arvedson et al., Thousand Oaks, United States. In Cell Metab, 2012
Hepcidin-induced ferroportin internalization did not require JAK2 or phosphorylation of ferroportin residues 302 and 303
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.
Impact
GeneRIF
Nemeth et al., Los Angeles, United States. In Cell Metab, 2012
ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis
[Hepcidin and diabetic anemia: is there an association?].
GeneRIF
Elias et al., Israel. In Harefuah, 2012
Based on the results of this small study, hepcidin was not associated with diabetic anemia
Intestinal ferritin H is required for an accurate control of iron absorption.
Impact
Kühn et al., Lausanne, Switzerland. In Cell Metab, 2010
To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.
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