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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hepcidin antimicrobial peptide

Hepcidin, hepcidin-25
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Transferrin, Interleukin-6, CAN, HAD, fibrillin-1
Papers on Hepcidin
Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length.
New
Ołtarzewski et al., Warsaw, Poland. In Biol Trace Elem Res, Feb 2016
UNASSIGNED: To estimate the effect of tobacco smoking on iron homeostasis and the possible association between hepcidin and the neonatal birth weight and length, concentrations of serum hepcidin and selected iron markers were measured in 81 healthy pregnant women (41 smokers and 40 nonsmokers).
Tipping the balance: Haemoglobinopathies and the risk of diabetes.
New
Patel et al., Nottingham, United Kingdom. In World J Diabetes, Feb 2016
Hepcidin is crucial in terms of maintaining appropriate amounts of iron in the body and is in turn affected by haemoglobinopathies.
Next-Generation Biomarkers for Iron Status.
New
Drakesmith, In Nestle Nutr Inst Workshop Ser, Dec 2015
The hierarchical master determinant of dietary iron absorption and iron distribution within the body is the peptide hormone hepcidin.
Genetics, Genetic Testing, and Management of Hemochromatosis: 15 Years Since Hepcidin.
Review
New
Pietrangelo, Modena, Italy. In Gastroenterology, Oct 2015
The discovery of hepcidin in 2000 and the subsequent unprecedented explosion of research and discoveries in the iron field have dramatically changed our understanding of human disorders of iron metabolism.
Iron deficiency anaemia.
Review
New
Impact
Peyrin-Biroulet et al., Nancy, France. In Lancet, Sep 2015
Hepcidin has a key role in iron homoeostasis and could be a future diagnostic and therapeutic target.
Hepcidin and Host Defense against Infectious Diseases.
Review
New
Mehrad et al., Charlottesville, United States. In Plos Pathog, Aug 2015
Hepcidin is the master regulator of iron homeostasis in vertebrates.
Serum hepcidin concentrations and type 2 diabetes.
Review
New
Tuomainen et al., Kuopio, Finland. In World J Diabetes, Aug 2015
Hepcidin is a peptide hormone with both paracrine and endocrine functions that help in maintaining body iron stores.
Hepcidin: regulation of the master iron regulator.
Review
Subramaniam et al., Brisbane, Australia. In Biosci Rep, 2014
This regulation is mediated by the iron-regulatory hormone hepcidin.
Increased hepcidin expression in non-small cell lung cancer tissue and serum is associated with clinical stage.
Yu et al., Changsha, China. In Thorac Cancer, 2014
METHODS: Serum hepcidin-25, bone morphogenetic protein (BMP)-2, and interleukin (IL)-6 concentration in 53 patients and 16 non-cancerous individuals was measured by enzyme-linked immune sorbent assay.
Systemic iron homeostasis.
Review
Impact
Ganz, In Physiol Rev, 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
Molecular Characterisation and Phylogenetic Analysis of a Novel Isoform of Hepatic Antimicrobial Peptide, Hepcidin (Zc-hepc1), from the Coral Fish Moorish idol, Zanclus cornutus (Linnaeus, 1758).
Bright Singh et al., Cochin, India. In Probiotics Antimicrob Proteins, 2013
The mature hepcidin, Zc-hepc1 has a theoretical isoelectric point of 7.46, a predicted molecular weight of 2.43 kDa and a net positive charge of +1.
A Novel Isoform of the Hepatic Antimicrobial Peptide, Hepcidin (Hepc-CB1), from a Deep-Sea Fish, the Spinyjaw Greeneye Chlorophthalmus bicornis (Norman, 1939): Molecular Characterisation and Phylogeny.
Bright Singh et al., Cochin, India. In Probiotics Antimicrob Proteins, 2013
Hepcidin is cysteine-rich short peptide of innate immune system of fishes, equipped to perform prevention and proliferation of invading pathogens like bacteria and viruses by limiting iron availability and activating intracellular cascades.
Hepcidin and the iron-infection axis.
Review
Impact
Prentice et al., Oxford, United Kingdom. In Science, 2012
Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
GeneRIF
Guo et al., Shanghai, China. In Febs J, 2012
labeled hepcidin was also a suitable tool to visualize internalization of overexpressed or even endogenously expressed ferroportin without tags
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
GeneRIF
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Impact
GeneRIF
Arvedson et al., Thousand Oaks, United States. In Cell Metab, 2012
Hepcidin-induced ferroportin internalization did not require JAK2 or phosphorylation of ferroportin residues 302 and 303
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.
Impact
GeneRIF
Nemeth et al., Los Angeles, United States. In Cell Metab, 2012
ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis
[Hepcidin and diabetic anemia: is there an association?].
GeneRIF
Elias et al., Israel. In Harefuah, 2012
Based on the results of this small study, hepcidin was not associated with diabetic anemia
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