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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 18 Nov 2014.

Hepcidin antimicrobial peptide

Hepcidin, hepcidin-25
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Transferrin, Interleukin-6, CAN, HAD, HFE
Papers on Hepcidin
Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells.
New
Dai et al., Guangzhou, China. In Mol Med Report, 31 Jan 2015
Hepcidin is closely associated with bone metabolism, however, it remains to be elucidated whether hepcidin affects osteogenic differentiation in MSCs.
Twice-Monthly Administration of a Lower Dose of Epoetin Beta Pegol Can Maintain Adequate Hemoglobin Levels in Hemodialysis Patients.
New
Sakai et al., Kōbe, Japan. In Ther Apher Dial, 17 Dec 2014
Although increases in ferritin and hepcidin-25 levels in the ONCE group were noted at one month, they disappeared at 6 months.
Impact of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes.
New
Pedlar et al., United Kingdom. In Med Sci Sports Exerc, 10 Dec 2014
Hepcidin levels were significantly greater before and after exercise following the iron injection (p <0.05) and this was independent of changes in interleukin-6.
Hepcidin and risk of anemia in CKD: a cross-sectional and longitudinal analysis in the CKiD cohort.
New
Furth et al., Baltimore, United States. In Pediatr Nephrol, 08 Dec 2014
BACKGROUND: Hepcidin, a key iron regulatory protein, is elevated in patients with chronic kidney disease (CKD).
The iron-regulatory hormone hepcidin: A possible therapeutic target?
Review
New
Vergely et al., Dijon, France. In Pharmacol Ther, 06 Oct 2014
Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis.
Mechanistic and regulatory aspects of intestinal iron absorption.
Review
New
Collins et al., Brisbane, Australia. In Am J Physiol Gastrointest Liver Physiol, Sep 2014
Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin.
Iron, anemia and hepcidin in malaria.
Review
New
Drakesmith et al., Bethesda, United States. In Front Pharmacol, Dec 2013
Key to understanding the pathophysiology of iron metabolism in malaria is the activity of the iron regulatory hormone hepcidin.
Hepcidin antagonists for potential treatments of disorders with hepcidin excess.
Review
New
Arosio et al., Brescia, Italy. In Front Pharmacol, Dec 2013
The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis.
The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract.
Review
New
Zekanowska et al., Bydgoszcz, Poland. In Prz Gastroenterol, Dec 2013
Hepcidin, a 25-amino acid polypeptide, which is synthesised primarily in hepatocytes, reduces the iron absorption from the intestine by binding to the only known cellular iron exporter, ferroportin, causing it to be degraded.
Growth differentiation factor 15 is related to anemia and iron metabolism in heart allograft recipients and patients with chronic heart failure.
New
Małyszko et al., Kraków, Poland. In Transplant Proc, Dec 2013
BACKGROUND: Growth differentiation factor (GDF) 15 was recently identified as a hepcidin-suppression factor that is expressed at high levels in patients with ineffective erythropoiesis.
Systemic iron homeostasis.
Review
New
Impact
Ganz, In Physiol Rev, Oct 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
Hepcidin and the iron-infection axis.
Review
Impact
Prentice et al., Oxford, United Kingdom. In Science, 2012
Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
GeneRIF
Guo et al., Shanghai, China. In Febs J, 2012
labeled hepcidin was also a suitable tool to visualize internalization of overexpressed or even endogenously expressed ferroportin without tags
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
GeneRIF
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Impact
GeneRIF
Arvedson et al., Thousand Oaks, United States. In Cell Metab, 2012
Hepcidin-induced ferroportin internalization did not require JAK2 or phosphorylation of ferroportin residues 302 and 303
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.
Impact
GeneRIF
Nemeth et al., Los Angeles, United States. In Cell Metab, 2012
ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis
[Hepcidin and diabetic anemia: is there an association?].
GeneRIF
Elias et al., Israel. In Harefuah, 2012
Based on the results of this small study, hepcidin was not associated with diabetic anemia
Intestinal ferritin H is required for an accurate control of iron absorption.
Impact
Kühn et al., Lausanne, Switzerland. In Cell Metab, 2010
To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.
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