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Hepcidin antimicrobial peptide

Hepcidin, hepcidin-25
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Transferrin, Interleukin-6, CAN, HAD, fibrillin-1
Papers on Hepcidin
Mass spectral analysis of urine proteomic profiles of dairy cows suffering from clinical ketosis.
Li et al., Daqing, China. In Vet Q, 26 Jun 2015
Among these were VGF (non-acronymic) protein, amyloid precursor protein, SAA, fibrinogen, C1INH, apolipoprotein C-III, Cystatin C, Transthyretin, Hepcidin, human neutrophil peptides and osteopontin.
Relationship between hepcidin and GDF15 in anemic patients with type 2 diabetes without overt renal impairment.
Kim et al., Taegu, South Korea. In Diabetes Res Clin Pract, 11 Jun 2015
We measured anthropometric and metabolic parameters, as well as measured the serum iron, ferritin, interleukin-6 (IL-6), erythropoietin, hepcidin-25 and GDF15 levels.
Hepcidin and iron disorders: new biology and clinical approaches.
Nemeth et al., Porto, Portugal. In Int J Lab Hematol, 31 May 2015
Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders.
Association between hepcidin, haemoglobin level and iron status in stage 4 chronic kidney disease patients with anaemia.
Bashardoust et al., Ardabīl, Iran. In J Pak Med Assoc, 30 Apr 2015
OBJECTIVE: To explore the probable association of serum hepcidin and haemoglobin levels with iron and inflammation statuses in patients of chronic kidney disease stage 4 with anaemia.
Hepcidin - A novel biomarker with changing trends.
Seetharam et al., Pondicherry, India. In Pharmacogn Rev, Jan 2015
Hepcidin is a novel peptide hormone of hepatic origin.
Mechanistic and regulatory aspects of intestinal iron absorption.
Collins et al., Brisbane, Australia. In Am J Physiol Gastrointest Liver Physiol, Sep 2014
Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin.
Hepcidin and iron homeostasis during pregnancy.
Nemeth et al., Chicago, United States. In Nutrients, Aug 2014
Hepcidin is the master regulator of systemic iron bioavailability in humans.
The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract.
Zekanowska et al., Bydgoszcz, Poland. In Prz Gastroenterol, 2013
Hepcidin, a 25-amino acid polypeptide, which is synthesised primarily in hepatocytes, reduces the iron absorption from the intestine by binding to the only known cellular iron exporter, ferroportin, causing it to be degraded.
[The role of hepcidin in iron metabolism in inflammatory bowel diseases].
Pac-Kozuchowska et al., In Postepy Hig Med Dosw (online), 2013
Hepcidin is a 25-amino-acid peptide synthesized predominantly in hepatocytes, which plays an essential role in the regulation of systemic iron homeostasis.
Anemia in inflammatory bowel disease: an under-estimated problem?
Vavricka et al., Zürich, Switzerland. In Front Med (lausanne), 2013
Hepcidin has been identified to be a central regulator of iron absorption from the intestine and of iron plasma levels.
Systemic iron homeostasis.
Ganz, In Physiol Rev, 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
Hepcidin and the iron-infection axis.
Prentice et al., Oxford, United Kingdom. In Science, 2012
Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
Guo et al., Shanghai, China. In Febs J, 2012
labeled hepcidin was also a suitable tool to visualize internalization of overexpressed or even endogenously expressed ferroportin without tags
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Arvedson et al., Thousand Oaks, United States. In Cell Metab, 2012
Hepcidin-induced ferroportin internalization did not require JAK2 or phosphorylation of ferroportin residues 302 and 303
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.
Nemeth et al., Los Angeles, United States. In Cell Metab, 2012
ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis
[Hepcidin and diabetic anemia: is there an association?].
Elias et al., Israel. In Harefuah, 2012
Based on the results of this small study, hepcidin was not associated with diabetic anemia
Intestinal ferritin H is required for an accurate control of iron absorption.
Kühn et al., Lausanne, Switzerland. In Cell Metab, 2010
To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.
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