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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Forkhead box A2

Hepatocyte Nuclear Factor 3-beta, Foxa2, HNF-3beta
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: HNF-3, CAN, Insulin, HAD, ACID
Papers on Hepatocyte Nuclear Factor 3-beta
Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids.
New
Revzin et al., Davis, United States. In Acta Biomater, Feb 2016
Mouse ESCs were encapsulated into heparin microgels with a single dose of Nodal and FGF-2, and expressed high levels of endoderm markers Sox17 and FoxA2 after 5 days.
The characterisation and functional β-cell differentiation of duck pancreas derived mesenchymal cells.
New
Zheng et al., Beijing, China. In Br Poult Sci, Feb 2016
The cell surface antigens of PSCs, FOXA2, SOX9, NKX6.1 and INS were detected by immunofluorescent stain and flow cytometry for determining the biological characteristics of PSCs.
Forkhead box protein A2 and T helper type 2-mediated pulmonary inflammation.
Review
New
Luo et al., Chengdu, China. In World J Methodol, Jan 2016
The transcription factor forkhead box protein A2 (FOXA2, also known as hepatocyte nuclear factor 3β or transcription factor 3β), has been found to play pivotal roles in multiple phases of mammalian life, from the early development to the organofaction, and subsequently in homeostasis and metabolism in the adult.
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.
New
Smith et al., Heidelberg, Germany. In Embo J, Jan 2016
Tcf7l1 represses FoxA2, a pioneer factor for endoderm specification.
Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study.
New
Sanghera et al., Oklahoma City, United States. In J Steroid Biochem Mol Biol, Jan 2016
p=4.47×10(-9)] between FOXA2 and SSTR4 was identified to be associated with 25(OH)D levels.
Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.
New
Tucker et al., Iowa City, United States. In Invest Ophthalmol Vis Sci, Jan 2016
Induced pluripotent stem cell-derived CECs express carbonic anhydrase IV, eNOS, FOXA2, PLVAP, CD31, CD34, ICAM-1, Tie2, TTR, VE-cadherin, and vWF.
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
New
Impact
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium et al., Stanford, United States. In Nat Genet, Dec 2015
Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association.
Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.
New
Impact
Sander et al., San Diego, United States. In Cell Stem Cell, May 2015
Furthermore, these enhancers are first recognized by the pioneer transcription factors FOXA1 and FOXA2 when competence is acquired, while subsequent recruitment of lineage-inductive transcription factors, such as PDX1, leads to enhancer and target gene activation.
The chondrocytic journey in endochondral bone growth and skeletal dysplasia.
Review
Cheah et al., Hong Kong, Hong Kong. In Birth Defects Res C Embryo Today, 2014
Chondrocyte hypertrophy, marked by dramatic volume increase in phases, is controlled by transcription factors SOX9, Runt-related transcription factor, and FOXA2.
Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing.
GeneRIF
Costa et al., Boston, United States. In Lung Cancer, 2012
The main mechanism of downregulation of Foxa2 is epigenetic silencing through promoter hypermethylation
Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.
GeneRIF
Ang et al., London, United Kingdom. In Development, 2012
Foxa2 regulates directly and positively key determinants of mDA neurons, including Lmx1a, Lmx1b, Msx1 and Ferd3l, while negatively inhibiting transcription factors expressed in ventrolateral midbrain.
Midbrain dopamine neurons from hESCs
Review
Tomishima, Cambridge, United States. In Unknown Journal, 2012
Later work by developmental biologists, however, discovered additional markers of these neurons that the Perrier cells lacked (e.g., FOXA2/TH).
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.
GeneRIF
Lassar et al., Boston, United States. In Dev Cell, 2012
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.
Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer.
Impact
GeneRIF
Kaestner et al., Philadelphia, United States. In Cell, 2012
Study uncovered a central role for Foxa1 and Foxa2 in controlling estrogen and androgen signaling through recruitment of ERalpha and AR to their relevant targets in the liver, thereby explaining the sexual dimorphism of liver cancer in mammals
The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals.
GeneRIF
Hansen et al., Copenhagen, Denmark. In Bmc Med Genet, 2011
FOXA2 rs1209523 was not significantly associated with fasting plasma glucose in glucose-tolerant individuals from the general Danish population of middle-aged people
Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.
GeneRIF
Kaestner et al., Philadelphia, United States. In Plos Genet, 2011
Foxa1 and Foxa2, while redundant during development, have evolved divergent roles in the adult liver, ensuring the maintenance of both genes during evolution.
Differentiation of definitive endoderm from mouse embryonic stem cells.
Review
Ong et al., Vancouver, Canada. In Results Probl Cell Differ, 2011
Efficient production of definitive endoderm needs to meet the specific criteria that include (a) increase in the production of markers of definitive endoderm such as Sox 17, FOXA2, GSC, and Mixl1; (b) decrease in the production of markers of primitive/visceral/parietal endoderm, Sox 7 and OCT4; and (c) decrease in the mesoderm markers (Brachyury, MEOX) and ectoderm markers (Sox1 and ZIC1).
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Impact
Birnbaum et al., Philadelphia, United States. In Cell Metab, 2011
Two forkhead transcription factors, FoxA2 and FoxO1, have been suggested to function downstream of and to be negatively regulated by Akt and are proposed as key determinants of hepatic triglyceride content.
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.
Impact
Marth et al., Santa Barbara, United States. In Nat Med, 2011
Elevated concentrations of free fatty acids caused nuclear exclusion and reduced expression of the transcription factors FOXA2 and HNF1A in beta cells.
Left-right asymmetry in embryonic development and breast cancer: common molecular determinants?
Review
Hagedorn et al., Göttingen, Germany. In Curr Med Chem, 2010
Pitx2, FoxA2) may be candidates with such overlapping functions.
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