Hepatocyte Nuclear Factor 3-beta
Forkhead box protein A2 and T helper type 2-mediated pulmonary inflammation.
Chengdu, China. In World J Methodol, Jan 2016
The transcription factor forkhead box protein A2 (FOXA2, also known as hepatocyte nuclear factor 3β or transcription factor 3β), has been found to play pivotal roles in multiple phases of mammalian life, from the early development to the organofaction, and subsequently in homeostasis and metabolism in the adult.
Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.
Iowa City, United States. In Invest Ophthalmol Vis Sci, Jan 2016
Induced pluripotent stem cell-derived CECs express carbonic anhydrase IV, eNOS, FOXA2, PLVAP, CD31, CD34, ICAM-1, Tie2, TTR, VE-cadherin, and vWF.
Midbrain dopamine neurons from hESCs
Cambridge, United States. In Unknown Journal, 2012
Later work by developmental biologists, however, discovered additional markers of these neurons that the Perrier cells lacked (e.g., FOXA2/TH).
Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer.
Philadelphia, United States. In Cell, 2012
Study uncovered a central role for Foxa1 and Foxa2 in controlling estrogen and androgen signaling through recruitment of ERalpha and AR to their relevant targets in the liver, thereby explaining the sexual dimorphism of liver cancer in mammals
Differentiation of definitive endoderm from mouse embryonic stem cells.
Vancouver, Canada. In Results Probl Cell Differ, 2011
Efficient production of definitive endoderm needs to meet the specific criteria that include (a) increase in the production of markers of definitive endoderm such as Sox 17, FOXA2, GSC, and Mixl1; (b) decrease in the production of markers of primitive/visceral/parietal endoderm, Sox 7 and OCT4; and (c) decrease in the mesoderm markers (Brachyury, MEOX) and ectoderm markers (Sox1 and ZIC1).