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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Hepatocyte growth factor

hepatocyte growth factor, HGF, c-Met, scatter factor
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, vascular endothelial growth factor, Akt
Papers using hepatocyte growth factor antibodies
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
Supplier
Li Jun, In PLoS ONE, 2008
... Total c-MET antibodies included Met (25H2) (Cell Signaling Technology, Danvers, MA) and ...
Phase I trial to determine the dose range for the c-Met inhibitor ARQ197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule.
Supplier
Aziz Syed, In PLoS ONE, 2007
... Biosciences, Pleasanton, CA), Human HGF affinity chromatography purified Anti-human HGF (R&D systems, Minneapolis, MN), Anti-human HGF Ab-2 (clone SBF5) (Thermo Scientific, Fremont, CA), human HGF ...
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Supplier
Shellman Yiqun G., In PLoS ONE, 2004
... 21 and deletion E746-A750 in exon 19) antibodies were from Cell Signaling Technology, anti-HER3 and anti-c-Met antibodies were from Santa Cruz Biotechnology, anti-α-tubulin antibody was from ...
Decorin evokes protracted internalization and degradation of the EGF receptor via caveolar endocytosis
Supplier
Iozzo Renato V. et al., In The Journal of Cell Biology, 2004
... Met C terminus (Santa Cruz Biotechnology, Inc.), Met N terminus (H9786 [Sigma-Aldrich] and AF276 [R&D Systems]), and HGF (Abcam).
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Papers on hepatocyte growth factor
Pharmacokinetics and safety of human recombinant hepatocyte growth factor administered to vocal folds.
New
Ito et al., Kyoto, Japan. In Laryngoscope, 30 Sep 2014
OBJECTIVES/HYPOTHESIS: Previous animal studies demonstrated that hepatocyte growth factor (HGF) has the potential to regenerate scarred vocal folds.
Recent advances and future trends in the targeted therapy of metastatic gastric cancer.
New
Werner et al., Frankfurt am Main, Germany. In Expert Rev Gastroenterol Hepatol, Jul 2014
These include the hepatocyte growth factor and its receptor c-MET, the insulin-like growth factor 1, the fibroblast growth factor, the mammalian target of rapamycin (mTOR), the epidermal growth factor receptor, and other pathways, as well as relevant immunotherapeutic strategies.
Hepatocyte growth factor and p38 promote osteogenic differentiation of human mesenchymal stem cells.
New
Howard et al., Miami, United States. In Mol Endocrinol, May 2014
Blocking endogenous HGF using PHA665752, a c-Met inhibitor (the HGF receptor), or an HGF-neutralizing antibody attenuates mineralization, and PHA665752 markedly reduced alkaline phosphatase activity.
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.
New
Impact
Stassi et al., Palermo, Italy. In Cell Stem Cell, Apr 2014
Cytokines hepatocyte growth factor (HGF), osteopontin (OPN), and stromal-derived factor 1α (SDF-1), secreted from tumor associated cells, increase CD44v6 expression in CR-CSCs by activating the Wnt/β-catenin pathway, which promotes migration and metastasis.
Placental villous mesenchymal cells trigger trophoblast invasion.
Review
New
Chen, Taipei, Taiwan. In Cell Adh Migr, Apr 2014
HGF produced by hPMSCs was able to engage c-Met receptor on trophoblast and induced the trophoblast cAMP expression.
Acquired resistance of non-small cell lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.
Review
New
Takahashi et al., Tokyo, Japan. In Respir Investig, Mar 2014
However, acquired resistance to gefitinib and erlotinib via EGFR-mutant NSCLC has occurred through various molecular mechanisms such as T790M secondary mutation, MET amplification, hepatocyte growth factor (HGF) overexpression, PTEN downregulation, epithelial-mesenchymal transition (EMT), and other mechanisms.
Renal carcinoma pharmacogenomics and predictors of response: Steps toward treatment individualization.
Review
New
Rodriguez-Antona et al., Madrid, Spain. In Urol Oncol, Mar 2014
Finally, germline mutations of the c-Met gene have been proposed as the first predictor of response to targeted therapies in papillary renal cell carcinoma.
[MET signalling pathway and its therapeutic implications in gastrointestinal cancers].
Review
New
Taieb et al., Paris, France. In Bull Cancer, Feb 2014
The MET receptor tyrosine kinase and its ligand HGF regulates many signalling pathways involved in proliferation and cell motility, invasion and angiogenesis.
Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signaling.
New
Cao et al., In Stem Cell Res Ther, Dec 2013
The expressions of angiogenic factors, including VEGF, bFGF, IGF-1 and HGF, were decreased in MSCs from aged mice.
Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer.
New
Impact
Peterson et al., Chattanooga, United States. In J Clin Oncol, Dec 2013
PURPOSE: Increased hepatocyte growth factor/MET signaling is associated with poor prognosis and acquired resistance to epidermal growth factor receptor (EGFR) -targeted drugs in patients with non-small-cell lung cancer (NSCLC).
Cabozantinib in progressive medullary thyroid cancer.
New
Impact
Sherman et al., Milano, Italy. In J Clin Oncol, Nov 2013
PURPOSE: Cabozantinib, a tyrosine kinase inhibitor (TKI) of hepatocyte growth factor receptor (MET), vascular endothelial growth factor receptor 2, and rearranged during transfection (RET), demonstrated clinical activity in patients with medullary thyroid cancer (MTC) in phase I. PATIENTS AND METHODS: We conducted a double-blind, phase III trial comparing cabozantinib with placebo in 330 patients with documented radiographic progression of metastatic MTC.
HGF signaling regulates Claudin-3 dynamics through its C-terminal tyrosine residues.
New
de Rooij et al., Utrecht, Netherlands. In Tissue Barriers, Nov 2013
The hormone HGF regulates morphogenesis and regeneration of multiple organs and increased HGF signaling is strongly associated with metastatic cancer.
MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Review
New
Impact
Wang et al., Hangzhou, China. In Nat Rev Cancer, Jul 2013
Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON (also known as MST1R) in the early 1990s, the roles of this signalling axis in cancer pathogenesis has been extensively studied in various model systems.
Phase III randomized, placebo-controlled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: an eastern cooperative oncology group trial.
New
Impact
Forastiere et al., San Antonio, United States. In J Clin Oncol, May 2013
EGFR, c-MET, and KRAS mutations and polymorphisms in drug metabolizing enzymes and transporters were evaluated by pyrosequencing.
Targeted therapies in development for non-small cell lung cancer.
Review
Dy et al., Bangkok, Thailand. In J Carcinog, 2012
In non-small cell lung cancer (NSCLC), the ErbB family of receptors (e.g., EGFR [epidermal growth factor receptor], HER2 [human epidermal growth factor receptor 2]), RAS (rat sarcoma gene), BRAF (v-raf murine sarcoma viral oncogene homolog B1), MAPK (mitogen-activated protein kinase) c-MET (c-mesenchymal-epithelial transition), FGFR (fibroblast growth factor receptor), DDR2 (discoidin domain receptor 2), PIK3CA (phosphatidylinositol-4,5-bisphosphate3-kinase, catalytic subunit alpha)), PTEN (phosphatase and tensin homolog), AKT (protein kinase B), ALK (anaplastic lym phoma kinase), RET (rearranged during transfection), ROS1 (reactive oxygen species 1) and EPH (erythropoietin-producing hepatoma) are key targets of various agents currently in clinical development.
Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis.
GeneRIF
Sadiq et al., New York City, United States. In J Neuroimmunol, 2012
There was decreased expression of hepatocyte growth factor in CSF cells as well as reduced CSF but not plasma HGF levels in multiple sclerosis patients. Patients with active disease had lower hepatocyte growth factor CSF levels than inactive disease.
The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.
GeneRIF
Hieronymus et al., Aachen, Germany. In J Immunol, 2012
These data unveil Met signaling in dendritic cells as a critical determinant for the maintenance of normal immune function
Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
GeneRIF
Tanzawa et al., Saitama, Japan. In Anticancer Res, 2012
levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.
Impact
GeneRIF
Bergers et al., San Francisco, United States. In Cancer Cell, 2012
demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2 heterocomplex
Clinical value of serum hepatocyte growth factor, B-cell lymphoma-2 and nitric oxide in primary breast cancer patients.
GeneRIF
Ramadan et al., Cairo, Egypt. In Eur Rev Med Pharmacol Sci, 2012
Serum levels of HGF, Bcl-2 or nitric oxide may help in the diagnosis of breast cancer patients and may aid in disease prognosis.
More papers using hepatocyte growth factor antibodies
Role of receptor tyrosine kinases in lung cancer
Supplier
Salgia Ravi et al., In Journal of Carcinogenesis, 2002
... Total c-Met was obtained from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Supplier
Sundan Anders et al., In European Journal of Haematology, 2002
... c-Met from Cell Signaling Technology (Beverly, MA, USA); ...
Phenotypic variation of retinal pigment epithelium in age-related macular degeneration
Supplier
Kim Yeong Hoon et al., In Korean Journal of Ophthalmology : KJO, 2001
... Rabbit anti-human c-Met polyclonal antibody and monoclonal antibody to human c-Met were acquired from Santa Cruz Biotechnology (C-28, Santa Cruz, CA, ...
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
Supplier
Sethi Jaswinder K., In PLoS ONE, 2001
... and HEPES were from Invitrogen (Carlsbad, CA), insulin from Lilly (Suresnes, France), PDGF-BB, IGF-1, and HGF from PeproTech (Rocky Hill, NJ), and 2-[3H]deoxyglucose from PerkinElmer Life (Waltham, MA) ...
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor
Supplier
Bandyopadhyay Sandip K. et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1999
... EIA kit, nitrate/ nitrite fluorometric assay kit, VEGF and HGF ELISA kits (Cayman Chem., Ann Arbor, MI, ...
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
Supplier
Brugge Joan S. et al., In The Journal of Cell Biology, 1998
... Antibodies to CSF-1R and c-Met were obtained from Santa Cruz Biotechnology, Inc.; laminin 5 from Chemicon; ...
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
Supplier
Fisher Elizabeth M. C. et al., In Disease Models & Mechanisms, 1996
... Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS ...
Proteoglycans as modulators of growth factor activities
Supplier
Pals Steven T. et al., In The Journal of Experimental Medicine, 1990
... Polyclonal antibodies used were rabbit anti–c-Met, C-12 (IgG) (Santa Cruz Biotechnology ...
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