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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hepatocyte growth factor

hepatocyte growth factor, HGF, c-Met, scatter factor
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, EGFR, HAD, vascular endothelial growth factor
Papers using hepatocyte growth factor antibodies
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
Supplier
Li Jun, In PLoS ONE, 2008
... Total c-MET antibodies included Met (25H2) (Cell Signaling Technology, Danvers, MA) and ...
Phase I trial to determine the dose range for the c-Met inhibitor ARQ197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule.
Supplier
Aziz Syed, In PLoS ONE, 2007
... Biosciences, Pleasanton, CA), Human HGF affinity chromatography purified Anti-human HGF (R&D systems, Minneapolis, MN), Anti-human HGF Ab-2 (clone SBF5) (Thermo Scientific, Fremont, CA), human HGF ...
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Supplier
Shellman Yiqun G., In PLoS ONE, 2004
... 21 and deletion E746-A750 in exon 19) antibodies were from Cell Signaling Technology, anti-HER3 and anti-c-Met antibodies were from Santa Cruz Biotechnology, anti-α-tubulin antibody was from ...
Decorin evokes protracted internalization and degradation of the EGF receptor via caveolar endocytosis
Supplier
Iozzo Renato V. et al., In The Journal of Cell Biology, 2004
... Met C terminus (Santa Cruz Biotechnology, Inc.), Met N terminus (H9786 [Sigma-Aldrich] and AF276 [R&D Systems]), and HGF (Abcam).
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Papers on hepatocyte growth factor
Elevated HGF Expression as an Autocrine c-Met Activation Mechanism in Acquired Resistance to Sorafenib in HCC Cells.
New
Atabey et al., İzmir, Turkey. In Cancer Sci, Feb 2016
Moreover, upon long term sorafenib treatment, HCC cells demonstrated induction of HGF synthesis and secretion along with increased levels of c-Met kinase and its active phosphorylated form indicating autocrine activation of HGF/c-Met signaling.
Recent progress in therapeutic strategy for ischemic stroke.
New
Abe et al., In Cell Transplant, Feb 2016
Thirdly, we administrated GDNF and hepatocyte growth factor (HGF) protein into post-ischemic rat brain, and estimated the infracted size and antiapoptotic and antiautophagic effects.
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
New
Impact
Hung et al., Houston, United States. In Nat Med, Feb 2016
Here we show that the receptor tyrosine kinase c-Met associates with and phosphorylates PARP1 at Tyr907 (PARP1 pTyr907 or pY907).
MET Exon 14 Mutations in Non-Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression.
New
Impact
Sholl et al., Boston, United States. In J Clin Oncol, Feb 2016
PURPOSE: Non-small-cell lung cancers (NSCLCs) harboring mutations in MET exon 14 and its flanking introns may respond to c-Met inhibitors.
Hepatocyte growth factor (HGF) and hemodialysis: physiopathology and clinical implications.
Review
New
Dal Canton et al., Pavia, Italy. In Clin Exp Nephrol, Jan 2016
UNASSIGNED: Hepatocyte growth factor (HGF) is a pleiotropic cytokine which exerts a variety of effects on several cells, being involved in the regulation of many biological processes, such as inflammation, tissue repair, morphogenesis, angiogenesis, tumour propagation, immunomodulation of viral infections and cardio-metabolic activities.
Recent advances in the development of dual VEGFR and c-Met small molecule inhibitors as anticancer drugs.
Review
New
Ouyang et al., Shenyang, China. In Eur J Med Chem, Jan 2016
On the other side, c-Met is the receptor of hepatocyte growth factor (HGF) and a receptor tyrosine kinase.
A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion.
New
El-Osta et al., Shreveport, United States. In Plos One, Dec 2015
Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in response to certain tumor microenvironment stimulus, such as hepatocyte growth factor (HGF) or acidic extracellular pH (pHe), increases cathepsin B secretion and tumor cell invasion.
Clinical impacts of a micropapillary pattern in lung adenocarcinoma: a review.
Review
New
Yuan et al., Hangzhou, China. In Onco Targets Ther, Dec 2015
Molecular markers, including vimentin, napsin A, phosphorylated c-Met, cytoplasmic maspin, Notch-1, MUC1, and tumoral CD10, may have higher expression in MPPAC than other subtypes; conversely, markers such as MUC4 and surfactant apoprotein A have lower expression in MPPAC.
Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing.
New
Pasquinelli et al., Bologna, Italy. In Stem Cells Int, Dec 2015
Hepatocyte Growth Factor/Scatter Factor (HGF/SF) is a pleiotropic cytokine exerting many biological activities through the c-Met receptor.
Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.
New
Trusolino et al., Torino, Italy. In Bmc Biol, Dec 2015
Using a panel of lung cancer cell lines as a model system, we found that abrogation of tankyrase activity by two different, structurally unrelated small-molecule inhibitors (one introduced and characterized here for the first time) or by RNA interference-based genetic silencing weakened cell migration, invasion, and directional movement induced by the motogenic cytokine hepatocyte growth factor.
Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.
New
Impact
Lo et al., Los Angeles, United States. In Cell, Oct 2015
We identified in the tumor cell compartment supra-physiologic c-MET up-expression, infra-physiologic LEF1 down-expression and YAP1 signature enrichment as drivers of acquired resistance.
Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met.
New
Impact
Hardwick et al., Leiden, Netherlands. In Nat Med, Aug 2015
Here we describe GE-137, a water-soluble probe consisting of a 26-amino acid cyclic peptide that binds the human tyrosine kinase c-Met conjugated to a fluorescent cyanine dye.
HGF Guides T Cells into the Heart.
New
Impact
Ley et al., Los Angeles, United States. In Immunity, Jul 2015
In this issue of Immunity, Komarowska et al. (2015) describe an autocrine loop that is initiated by cardiac-expressed hepatocyte growth factor to direct T cells into the heart during inflammation and cardiac transplant rejection.
Overview of fundamental study of pazopanib in cancer.
Review
Zhou et al., Tianjin, China. In Thorac Cancer, 2014
In vivo xenograft studies and phase I/II clinical trials revealed a series of plasma cytokine and angiogenic factors, such as interleukin (IL)-6, IL-12, hepatocyte growth factor (HGF), and soluble VEGFR2, which have significant association with clinical curative effect.
Gastric Cancer: New Drugs - New Strategies.
Review
Härtel et al., Mannheim, Germany. In Gastrointest Tumors, 2014
This review examines the main molecular targets in the treatment of gastric cancer, namely the vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER2), hepatocyte growth factor (HGF)/c-Met, epidermal growth factor receptor (EGFR) and phosphoinositide 3-kinase (PI3K)/Akt pathways.
Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis.
GeneRIF
Sadiq et al., New York City, United States. In J Neuroimmunol, 2012
There was decreased expression of hepatocyte growth factor in CSF cells as well as reduced CSF but not plasma HGF levels in multiple sclerosis patients. Patients with active disease had lower hepatocyte growth factor CSF levels than inactive disease.
The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.
GeneRIF
Hieronymus et al., Aachen, Germany. In J Immunol, 2012
These data unveil Met signaling in dendritic cells as a critical determinant for the maintenance of normal immune function
Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
GeneRIF
Tanzawa et al., Saitama, Japan. In Anticancer Res, 2012
levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.
Impact
GeneRIF
Bergers et al., San Francisco, United States. In Cancer Cell, 2012
demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2 heterocomplex
Clinical value of serum hepatocyte growth factor, B-cell lymphoma-2 and nitric oxide in primary breast cancer patients.
GeneRIF
Ramadan et al., Cairo, Egypt. In Eur Rev Med Pharmacol Sci, 2012
Serum levels of HGF, Bcl-2 or nitric oxide may help in the diagnosis of breast cancer patients and may aid in disease prognosis.
More papers using hepatocyte growth factor antibodies
Role of receptor tyrosine kinases in lung cancer
Supplier
Salgia Ravi et al., In Journal of Carcinogenesis, 2002
... Total c-Met was obtained from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Supplier
Sundan Anders et al., In European Journal of Haematology, 2002
... c-Met from Cell Signaling Technology (Beverly, MA, USA); ...
Phenotypic variation of retinal pigment epithelium in age-related macular degeneration
Supplier
Kim Yeong Hoon et al., In Korean Journal of Ophthalmology : KJO, 2001
... Rabbit anti-human c-Met polyclonal antibody and monoclonal antibody to human c-Met were acquired from Santa Cruz Biotechnology (C-28, Santa Cruz, CA, ...
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
Supplier
Sethi Jaswinder K., In PLoS ONE, 2001
... and HEPES were from Invitrogen (Carlsbad, CA), insulin from Lilly (Suresnes, France), PDGF-BB, IGF-1, and HGF from PeproTech (Rocky Hill, NJ), and 2-[3H]deoxyglucose from PerkinElmer Life (Waltham, MA) ...
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor
Supplier
Bandyopadhyay Sandip K. et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1999
... EIA kit, nitrate/ nitrite fluorometric assay kit, VEGF and HGF ELISA kits (Cayman Chem., Ann Arbor, MI, ...
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
Supplier
Brugge Joan S. et al., In The Journal of Cell Biology, 1998
... Antibodies to CSF-1R and c-Met were obtained from Santa Cruz Biotechnology, Inc.; laminin 5 from Chemicon; ...
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
Supplier
Fisher Elizabeth M. C. et al., In Disease Models & Mechanisms, 1996
... Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS ...
Proteoglycans as modulators of growth factor activities
Supplier
Pals Steven T. et al., In The Journal of Experimental Medicine, 1990
... Polyclonal antibodies used were rabbit anti–c-Met, C-12 (IgG) (Santa Cruz Biotechnology ...
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