gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Hepatocyte growth factor

hepatocyte growth factor, HGF, c-Met, scatter factor
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, EGFR, HAD, Akt
Papers using hepatocyte growth factor antibodies
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
Li Jun, In PLoS ONE, 2008
... Total c-MET antibodies included Met (25H2) (Cell Signaling Technology, Danvers, MA) and ...
Phase I trial to determine the dose range for the c-Met inhibitor ARQ197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule.
Aziz Syed, In PLoS ONE, 2007
... Biosciences, Pleasanton, CA), Human HGF affinity chromatography purified Anti-human HGF (R&D systems, Minneapolis, MN), Anti-human HGF Ab-2 (clone SBF5) (Thermo Scientific, Fremont, CA), human HGF ...
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Shellman Yiqun G., In PLoS ONE, 2004
... 21 and deletion E746-A750 in exon 19) antibodies were from Cell Signaling Technology, anti-HER3 and anti-c-Met antibodies were from Santa Cruz Biotechnology, anti-α-tubulin antibody was from ...
Decorin evokes protracted internalization and degradation of the EGF receptor via caveolar endocytosis
Iozzo Renato V. et al., In The Journal of Cell Biology, 2004
... Met C terminus (Santa Cruz Biotechnology, Inc.), Met N terminus (H9786 [Sigma-Aldrich] and AF276 [R&D Systems]), and HGF (Abcam).
more suppliers
Papers on hepatocyte growth factor
Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites.
Reddy et al., Houston, United States. In Cancer Biol Ther, 09 Dec 2015
KRAS-mutated mCRC had higher protein expression of c-MET (47% vs. 36%) and lower MGMT (56% vs. 63%), suggesting consideration of c-MET inhibitors and temozolomide.
Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration.
Sobue et al., Nagoya, Japan. In Biochem Biophys Res Commun, 07 Dec 2015
Hepatocyte growth factor (HGF) is a polypeptide growth factor which has neuroprotective properties.
Cytokine Dosage in Fresh and Preserved Human Amniotic Membrane.
Silveira et al., São Paulo, Brazil. In Cornea, 06 Dec 2015
An enzyme-linked immunosorbent assay was performed on the supernatant for detection of the following cytokines: epidermal growth factor, basic fibroblast growth factor, hepatocyte growth factor, keratinocyte growth factor, transforming growth factor-beta, and interleukins 4 and 10, and the findings were assessed by post hoc analysis of variance.
Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship.
Bharate et al., Jammu, India. In Eur J Med Chem, 01 Dec 2015
Thus, fascaplysin and its analogs showing promising P-gp induction along with AChE inhibition at 1 μM, with good safety window (LS-180: IC50 > 10 μM, hGF: 4 μM), clearly indicates their promise for development as an anti-Alzheimer agent.
Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer.
Lai et al., Tainan City, Taiwan. In Oncotarget, 22 Nov 2015
The natural carcinogenic molecules TGF-β-1, HGF, and hepatitis B surface antigen increased the expression of CD90 and CD133.
Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: Are we getting there?
Cheng et al., Taipei, Taiwan. In World J Gastroenterol, 28 Oct 2015
Studies based on patient cohorts identified the potential of blood levels of angiopoietin-2, hepatocyte growth factor, insulin-like growth factor-1, and transforming growth factor-β1 for predicting sorafenib efficacy.
Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.
Lo et al., Los Angeles, United States. In Cell, 10 Oct 2015
We identified in the tumor cell compartment supra-physiologic c-MET up-expression, infra-physiologic LEF1 down-expression and YAP1 signature enrichment as drivers of acquired resistance.
Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease.
Nishimatsu et al., Kawasaki, Japan. In World J Cardiol, Sep 2015
ADSCs also produce a variety of paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor-1 that have proangiogenic and/or antiapoptotic activities.
Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met.
Hardwick et al., Leiden, Netherlands. In Nat Med, Aug 2015
Here we describe GE-137, a water-soluble probe consisting of a 26-amino acid cyclic peptide that binds the human tyrosine kinase c-Met conjugated to a fluorescent cyanine dye.
MET deregulation in breast cancer.
Landi et al., Livorno, Italy. In Ann Transl Med, Aug 2015
BACKGROUND: Mesenchymal-epithelial transition (MET) is an oncogene encoding for a trans-membrane tyrosine kinase receptor activated by the hepatocyte growth factor (HGF).
MET is required for the recruitment of anti-tumoural neutrophils.
Mazzone et al., Leuven, Belgium. In Nature, Jul 2015
Here we show that MET is required for neutrophil chemoattraction and cytotoxicity in response to its ligand hepatocyte growth factor (HGF).
HGF Guides T Cells into the Heart.
Ley et al., Los Angeles, United States. In Immunity, Jul 2015
In this issue of Immunity, Komarowska et al. (2015) describe an autocrine loop that is initiated by cardiac-expressed hepatocyte growth factor to direct T cells into the heart during inflammation and cardiac transplant rejection.
Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release.
Marelli-Berg et al., Copenhagen, Denmark. In Immunity, Jul 2015
We report that engagement of the hepatocyte growth factor (HGF) receptor c-Met by heart-produced HGF during priming in the lymph nodes instructs T cell cardiotropism, which was associated with a specialized homing "signature" (c-Met(+)CCR4(+)CXCR3(+)). c-Met signals facilitated T cell recruitment to the heart via the chemokine receptor CCR5 by inducing autocrine CCR5 ligand release.
Hepatocyte Growth Factor from a Clinical Perspective: A Pancreatic Cancer Challenge.
Trevino et al., Hyderābād, India. In Cancers (basel), Dec 2014
A major factor regulating desmoplasia and subsequently promoting chemoresistance in pancreatic cancer is hepatocyte growth factor (HGF), the sole ligand for c-MET (mesenchymal-epithelial transition), an epithelial tyrosine kinase receptor.
Development of Tivantinib as Treatment for Hepatocellular Carcinoma.
Frenette et al., Los Angeles, United States. In J Clin Transl Hepatol, 2013
The c-Met pathway has been found to be an important pathway in half of all patients with HCC.
Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis.
Sadiq et al., New York City, United States. In J Neuroimmunol, 2012
There was decreased expression of hepatocyte growth factor in CSF cells as well as reduced CSF but not plasma HGF levels in multiple sclerosis patients. Patients with active disease had lower hepatocyte growth factor CSF levels than inactive disease.
The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.
Hieronymus et al., Aachen, Germany. In J Immunol, 2012
These data unveil Met signaling in dendritic cells as a critical determinant for the maintenance of normal immune function
Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
Tanzawa et al., Saitama, Japan. In Anticancer Res, 2012
levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.
Bergers et al., San Francisco, United States. In Cancer Cell, 2012
demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2 heterocomplex
Clinical value of serum hepatocyte growth factor, B-cell lymphoma-2 and nitric oxide in primary breast cancer patients.
Ramadan et al., Cairo, Egypt. In Eur Rev Med Pharmacol Sci, 2012
Serum levels of HGF, Bcl-2 or nitric oxide may help in the diagnosis of breast cancer patients and may aid in disease prognosis.
More papers using hepatocyte growth factor antibodies
Role of receptor tyrosine kinases in lung cancer
Salgia Ravi et al., In Journal of Carcinogenesis, 2002
... Total c-Met was obtained from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Sundan Anders et al., In European Journal of Haematology, 2002
... c-Met from Cell Signaling Technology (Beverly, MA, USA); ...
Phenotypic variation of retinal pigment epithelium in age-related macular degeneration
Kim Yeong Hoon et al., In Korean Journal of Ophthalmology : KJO, 2001
... Rabbit anti-human c-Met polyclonal antibody and monoclonal antibody to human c-Met were acquired from Santa Cruz Biotechnology (C-28, Santa Cruz, CA, ...
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
Sethi Jaswinder K., In PLoS ONE, 2001
... and HEPES were from Invitrogen (Carlsbad, CA), insulin from Lilly (Suresnes, France), PDGF-BB, IGF-1, and HGF from PeproTech (Rocky Hill, NJ), and 2-[3H]deoxyglucose from PerkinElmer Life (Waltham, MA) ...
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor
Bandyopadhyay Sandip K. et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1999
... EIA kit, nitrate/ nitrite fluorometric assay kit, VEGF and HGF ELISA kits (Cayman Chem., Ann Arbor, MI, ...
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
Brugge Joan S. et al., In The Journal of Cell Biology, 1998
... Antibodies to CSF-1R and c-Met were obtained from Santa Cruz Biotechnology, Inc.; laminin 5 from Chemicon; ...
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
Fisher Elizabeth M. C. et al., In Disease Models & Mechanisms, 1996
... Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS ...
Proteoglycans as modulators of growth factor activities
Pals Steven T. et al., In The Journal of Experimental Medicine, 1990
... Polyclonal antibodies used were rabbit anti–c-Met, C-12 (IgG) (Santa Cruz Biotechnology ...
share on facebooktweetadd +1mail to friends