GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Hepatocyte growth factor
hepatocyte growth factor, HGF, c-Met, scatter factor
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
hepatocyte growth factor
antibodies
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
Supplier
In PLoS ONE, 2008
Phase I trial to determine the dose range for the c-Met inhibitor ARQ197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule.
Supplier
In PLoS ONE, 2007
... Biosciences, Pleasanton, CA), Human HGF affinity chromatography purified Anti-human HGF (R&D systems, Minneapolis, MN), Anti-human HGF Ab-2 (clone SBF5) (Thermo Scientific, Fremont, CA), human HGF ...
Decorin evokes protracted internalization and degradation of the EGF receptor via caveolar endocytosis
Supplier
In The Journal of Cell Biology, 2004
... Met C terminus (Santa Cruz Biotechnology, Inc.), Met N terminus (H9786 [Sigma-Aldrich] and AF276 [R&D Systems]), and HGF (Abcam).
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Supplier
In PLoS ONE, 2004
... 21 and deletion E746-A750 in exon 19) antibodies were from Cell Signaling Technology, anti-HER3 and anti-c-Met antibodies were from Santa Cruz Biotechnology, anti-α-tubulin antibody was from ...
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
more suppliersSupplier
In Gene therapy, 2003
... , HGF-transgenic mouse.
Papers on
hepatocyte growth factor
MET As a Possible Target for Non-Small-Cell Lung Cancer.
New
Impact
United States. In J Clin Oncol, 10 Apr 2013
The ligand hepatocyte growth factor (HGF) can also be overexpressed in lung cancer or expressed in stroma, and both the MET receptor and the HGF ligand can be targets for therapeutics, especially in lung cancer.
Phase III Randomized, Placebo-Controlled Trial of Docetaxel With or Without Gefitinib in Recurrent or Metastatic Head and Neck Cancer: An Eastern Cooperative Oncology Group Trial.
New
Impact
San Antonio, United States. In J Clin Oncol, 04 Apr 2013
EGFR, c-MET, and KRAS mutations and polymorphisms in drug metabolizing enzymes and transporters were evaluated by pyrosequencing.ResultsTwo hundred seventy patients were enrolled before the study was closed early at interim analysis (arm A, n = 136; arm B, n = 134).
Protective Effects of Hepatocyte Growth Factor on Hypoxic HumanPulmonary Microvascular Endothelial Cells.
New
Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 31 Mar 2013
Objective To investigate the protective effects of hepatocyte growth factor (HGF) on hypoxic human pulmonary microvascular endothelial cells (HPMECs).
Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.
New
Shanghai, China. In Bioorg Med Chem Lett, 14 Mar 2013
A series of novel 5-(benzyloxy)pyridin-2(1H)-ones were designed, synthesized and biologically evaluated for c-Met inhibition.
A Necrotic Stimulus is Required to Maximize Matrix-Mediated Myogenesis.
New
Ottawa, Canada. In Dis Model Mech, 14 Mar 2013
Furthermore, conditioned medium collected from satellite cells cultured with both stimuli contained elevated levels of factors that modulate satellite cell activation and proliferation, such as FGF-2, HGF and SDF-1.
[Biomechanic and biological activity assessment of concavity-convex amniotic membrane].
New
Nanchang, China. In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, Dec 2012
The content of 10 cytokines [epidermal growth factor (EGF), fibroblast growth factor (FGF), b-fibroblast growth factor b-FGF, hepatocyte growth factor (HGF), transforming growth factor-beta (TGF-beta), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), nerve growth factor (NGF), brain-derived nellrotrophic factor (BDNF), ciliary neurotrophic factor (CNTF)] of CCAM decreased significantly compared with the FAM and increased significantly compared with MAM and DAM in 6 cytokines (EGF, FGF, HGF, TGF-betap, PDGF, NGF; P < 0.05).
New insights into the management of renal cell cancer.
Review
New
Paris, France. In Oncology, Dec 2012
Besides, co-inhibition of signalling pathways mediating resistance to anti-VEGF are being developed targeting fibroblast growth factor and c-Met.
Receptor tyrosine kinases: principles and functions in glioma invasion.
Review
New
Kanazawa, Japan. In Adv Exp Med Biol, Dec 2012
Recent studies have revealed that RTKs such as epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), c-Met, Tie, Axl, discoidin domain receptor 1 (DDR1), and erythropoietin-producing human hepatocellular carcinoma (Eph) play a major role in glioma invasion.
Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells.
New
Hong Kong, Hong Kong. In Plos One, Dec 2012
While increased expression of major angiogenic factors including epidermal growth factor, hepatocyte growth factor, vascular endothelial growth factor, placental growth factor and stromal derived factor-1 were observed in all EC cultures during hypoxia compared with normoxia (), the magnitudes of cytokine up-regulation upon hypoxic were more dramatic in hiPSC-EC and hESC-EC ().
Racial differences between blacks and whites with systemic sclerosis.
Review
New
Charleston, United States. In Curr Opin Rheumatol, Nov 2012
Racial differences in the expression of transforming growth factor-β1 (TGF-β1) and caveolin-1, as well as differences in the expression of hepatocyte growth factor and PPAR-γ, have been demonstrated in blacks with SSc, as well as in normal black individuals.
[Therapeutic biomarkers of EGFR-TKI].
Review
New
Tokyo, Japan. In Gan To Kagaku Ryoho, Nov 2012
Several acquired-resistance mechanisms and candidates, including exon 20 T790M secondary mutation, MET amplification, a high-level of HGF expression, PTEN downregulation, FAS-NF-κB pathway activation, epithelial-mesenchymal transition, and conversion to small cell lung cancer, have been identified.
Targeting the hepatocyte growth factor-cMET axis in cancer therapy.
New
Impact
Houston, United States. In J Clin Oncol, Oct 2012
The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic changes that stimulate tissue repair and regeneration in normal cells but can be co-opted during tumor growth.
Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling.
New
Impact
Bethesda, United States. In Cancer Cell, Sep 2012
Hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) regulate normal development and homeostasis and drive disease progression in many forms of cancer.
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.
New
Impact
San Francisco, United States. In Cancer Cell, Aug 2012
Here, we demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2 heterocomplex, thereby suppressing HGF-dependent MET phosphorylation and tumor cell migration.
Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer.
Impact
GeneRIF
Pesaro, Italy. In J Clin Oncol, 2012
qPCR revealed approximately 10% of white patients with gastric cancer harboring MET copy number gain (CNG)of five or more copies.
Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.
Impact
GeneRIF
Boston, United States. In Cancer Cell, 2012
multiple receptor tyrosine kinases are amplified in a subset of glioblastoma subclones, epidermal growth factor receptor, MET and platelet-derived growth factor receptor alpha
A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism.
Impact
GeneRIF
Pittsburgh, United States. In Nat Med, 2011
Met stimulates hepatocyte glucose uptake through crosstalk with insulin receptor.
Advances in molecular targets for the treatment of medulloblastomas.
Review
Québec, Canada. In Clin Invest Med, 2011
Evidence showing several molecular and pharmacological targets within key signalling pathways, such as HEDGEHOG, WNT, NOTCH, Receptor Tyrosine Kinase (ERB, IGF-IR, c-MET, PDGF, Estrogen, p75NTR) , their downstream effectors like PI3K/AKT, c-MYC and STAT3, and as well as other targets such as telomerase and cytoskeletal elements, is summarized.
Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus.
GeneRIF
Adelaide, Australia. In Invest Ophthalmol Vis Sci, 2011
Taken together, these results implicate genetic variation at the HGF locus with keratoconus susceptibility.
Hepatocyte growth factor-induced amelioration in renal interstitial fibrosis is associated with reduced expression of alpha-smooth muscle actin and transforming growth factor-beta1.
More papers using
hepatocyte growth factor
antibodies
GeneRIF
Changchun, China. In Indian J Biochem Biophys, 2011
Hepatocyte growth factor-induced amelioration in renal interstitial fibrosis is associated with reduced expression of alpha-smooth muscle actin and transforming growth factor-beta1
Role of receptor tyrosine kinases in lung cancer
Supplier
In Journal of Carcinogenesis, 2002
... Total c-Met was obtained from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Supplier
In European Journal of Haematology, 2002
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
Supplier
In PLoS ONE, 2001
... and HEPES were from Invitrogen (Carlsbad, CA), insulin from Lilly (Suresnes, France), PDGF-BB, IGF-1, and HGF from PeproTech (Rocky Hill, NJ), and 2-[3H]deoxyglucose from PerkinElmer Life (Waltham, MA) ...
Phenotypic variation of retinal pigment epithelium in age-related macular degeneration
Supplier
In Korean Journal of Ophthalmology : KJO, 2001
... Rabbit anti-human c-Met polyclonal antibody and monoclonal antibody to human c-Met were acquired from Santa Cruz Biotechnology (C-28, Santa Cruz, CA, ...
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 1999
... EIA kit, nitrate/ nitrite fluorometric assay kit, VEGF and HGF ELISA kits (Cayman Chem., Ann Arbor, MI, ...
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
Supplier
In The Journal of Cell Biology, 1998
... Antibodies to CSF-1R and c-Met were obtained from Santa Cruz Biotechnology, Inc.; laminin 5 from Chemicon; ...
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
Supplier
In Disease Models & Mechanisms, 1996
... Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS ...
Proteoglycans as modulators of growth factor activities
Supplier
In The Journal of Experimental Medicine, 1990
... Polyclonal antibodies used were rabbit anti–c-Met, C-12 (IgG) (Santa Cruz Biotechnology ...
