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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Jul 2015.

Hepatocyte growth factor

hepatocyte growth factor, HGF, c-Met, scatter factor
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, Akt, EGFR
Papers using hepatocyte growth factor antibodies
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
Li Jun, In PLoS ONE, 2008
... Total c-MET antibodies included Met (25H2) (Cell Signaling Technology, Danvers, MA) and ...
Phase I trial to determine the dose range for the c-Met inhibitor ARQ197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule.
Aziz Syed, In PLoS ONE, 2007
... Biosciences, Pleasanton, CA), Human HGF affinity chromatography purified Anti-human HGF (R&D systems, Minneapolis, MN), Anti-human HGF Ab-2 (clone SBF5) (Thermo Scientific, Fremont, CA), human HGF ...
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Shellman Yiqun G., In PLoS ONE, 2004
... 21 and deletion E746-A750 in exon 19) antibodies were from Cell Signaling Technology, anti-HER3 and anti-c-Met antibodies were from Santa Cruz Biotechnology, anti-α-tubulin antibody was from ...
Decorin evokes protracted internalization and degradation of the EGF receptor via caveolar endocytosis
Iozzo Renato V. et al., In The Journal of Cell Biology, 2004
... Met C terminus (Santa Cruz Biotechnology, Inc.), Met N terminus (H9786 [Sigma-Aldrich] and AF276 [R&D Systems]), and HGF (Abcam).
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Papers on hepatocyte growth factor
Useful properties of undifferentiated mesenchymal stromal cells and adipose tissue as the source in liver-regenerative therapy studied in an animal model of severe acute fulminant hepatitis.
Malheiros Luzo et al., Campinas, Brazil. In Cytotherapy, 31 Aug 2015
Hepatocyte differentiation protocol was performed with the use of Dulbecco's modified Eagle's medium, hepatocyte growth factor, basic fibroblast growth factor and nicotinamide (7 days); maturation medium (oncostatin, dexamethasone, insulin, transferrin and selenium) was added at 36 days.
Increased gene copy number of HER2 and concordant protein overexpression found in a subset of eyelid sebaceous gland carcinoma indicate HER2 as a potential therapeutic target.
Kim et al., Anyang, South Korea. In J Cancer Res Clin Oncol, 04 Aug 2015
METHODS: The expression levels of HER2, EGFR, C-MET, and FGFR1 were determined by immunohistochemistry (IHC).
Depleting MET-expressing tumor cells by ADCC provides a therapeutic advantage over inhibiting HGF/MET signaling.
Michieli et al., Gent, Belgium. In Cancer Res, 03 Aug 2015
UNASSIGNED: Hepatocyte growth factor (HGF) and its receptor MET represent validated targets for cancer therapy.
New molecular targets in non clear renal cell carcinoma: An overview of ongoing clinical trials.
Montironi et al., Verona, Italy. In Cancer Treat Rev, 31 Jul 2015
Interestingly, other than mTOR and VEGF pathways, tumor proliferation of some nccRCC histotypes seems to depend on alternative signaling pathways, as demonstrated by the close correlation between papillary RCC and activation of the HGF/MET axis.
Angiogenesis Biomarkers May Be Useful in the Management of Patients With Indeterminate Pulmonary Nodules.
Borgia et al., Chicago, United States. In Ann Thorac Surg, 30 Jul 2015
Our previously reported multi-analyte classification panel was refined to include interleukin (IL)-6, IL-10, IL-1 receptor antagonist (RA), tumor necrosis factor (TNF)-α, insulin-like growth factor binding protein (IGFBP)-5, IGFBP-4, IGF-2, stromal cell-derived factor (SDF)-1(α+β), HB-EGF, and HGF resulting in improved accuracy and a validated negative predictive value of 96.4%.
Vascularized subcutaneous human liver tissue from engineered hepatocyte/fibroblast sheets in mice.
Eguchi et al., Nagasaki, Japan. In Biomaterials, 27 Jul 2015
The engineered hepatocyte/fibroblast sheets (EHFSs) showed superior expression levels of vascularization-associated growth factors (vascular endothelial growth factor, transforming growth factor beta 1, and hepatocyte growth factor) in vitro.
MET is required for the recruitment of anti-tumoural neutrophils.
Mazzone et al., Leuven, Belgium. In Nature, 18 Jul 2015
Here we show that MET is required for neutrophil chemoattraction and cytotoxicity in response to its ligand hepatocyte growth factor (HGF).
HGF Guides T Cells into the Heart.
Ley et al., Los Angeles, United States. In Immunity, 16 Jul 2015
(2015) describe an autocrine loop that is initiated by cardiac-expressed hepatocyte growth factor to direct T cells into the heart during inflammation and cardiac transplant rejection.
Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release.
Marelli-Berg et al., Copenhagen, Denmark. In Immunity, 16 Jul 2015
We report that engagement of the hepatocyte growth factor (HGF) receptor c-Met by heart-produced HGF during priming in the lymph nodes instructs T cell cardiotropism, which was associated with a specialized homing "signature" (c-Met(+)CCR4(+)CXCR3(+)). c-Met signals facilitated T cell recruitment to the heart via the chemokine receptor CCR5 by inducing autocrine CCR5 ligand release.
Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461.
Wang et al., Shanghai, China. In Bioorg Med Chem Lett, 01 Jul 2015
UNASSIGNED: Two series of novel 1,5-naphthyridine and 1,6-naphthyridine derivatives were designed and synthesized based on the c-Met kinase inhibitor MK-2461 under the guidance of scaffold hopping strategy.
New targeted therapies in pancreatic cancer.
Seicean et al., Cluj-Napoca / Kolozsvár, Romania. In World J Gastroenterol, 28 Jun 2015
It includes mainly therapies targeting against kinases, including epidermal growth factor receptor, Ras/Raf/mitogen-activated protein kinase cascade, human epidermal growth factor receptor 2, insulin growth factor-1 receptor, phosphoinositide 3-kinase/Akt/mTOR and hepatocyte growth factor receptor.
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.
Wells et al., Cincinnati, United States. In Nature, Jan 2015
Using hGOs to model pathogenesis of human disease, we found that H. pylori infection resulted in rapid association of the virulence factor CagA with the c-Met receptor, activation of signalling and induction of epithelial proliferation.
Neuropilin-1 as Therapeutic Target for Malignant Melanoma.
Lacal et al., Roma, Italy. In Front Oncol, Dec 2014
Its ability to bind or modulate the activity of a number of other extracellular ligands, such as class 3 semaphorins, TGF-β, HGF, FGF, and PDGF, has suggested the involvement of NRP-1 in a variety of physiological and pathological processes.
The roles of signaling pathways in epithelial-to-mesenchymal transition of PVR.
Li et al., Tianjin, China. In Mol Vis, Dec 2014
In this article, we review research to date about the roles of such signaling, including including transforming growth factor-beta-, hepatocyte growth factor-, platelet-derived growth factor-, and Notch-, Wnt/β-catenin-, and Hippo-signaling pathways, in the EMT of PVR.
Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate.
Beachy et al., Stanford, United States. In Nat Cell Biol, Dec 2014
Decreased pathway activity correlates with increased stromal production of hepatocyte growth factor (Hgf), and we show that Hgf induces epithelial tubule branching.
Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis.
Sadiq et al., New York City, United States. In J Neuroimmunol, 2012
There was decreased expression of hepatocyte growth factor in CSF cells as well as reduced CSF but not plasma HGF levels in multiple sclerosis patients. Patients with active disease had lower hepatocyte growth factor CSF levels than inactive disease.
The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.
Hieronymus et al., Aachen, Germany. In J Immunol, 2012
These data unveil Met signaling in dendritic cells as a critical determinant for the maintenance of normal immune function
Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
Tanzawa et al., Saitama, Japan. In Anticancer Res, 2012
levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.
Bergers et al., San Francisco, United States. In Cancer Cell, 2012
demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2 heterocomplex
Clinical value of serum hepatocyte growth factor, B-cell lymphoma-2 and nitric oxide in primary breast cancer patients.
Ramadan et al., Cairo, Egypt. In Eur Rev Med Pharmacol Sci, 2012
Serum levels of HGF, Bcl-2 or nitric oxide may help in the diagnosis of breast cancer patients and may aid in disease prognosis.
More papers using hepatocyte growth factor antibodies
Role of receptor tyrosine kinases in lung cancer
Salgia Ravi et al., In Journal of Carcinogenesis, 2002
... Total c-Met was obtained from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Sundan Anders et al., In European Journal of Haematology, 2002
... c-Met from Cell Signaling Technology (Beverly, MA, USA); ...
Phenotypic variation of retinal pigment epithelium in age-related macular degeneration
Kim Yeong Hoon et al., In Korean Journal of Ophthalmology : KJO, 2001
... Rabbit anti-human c-Met polyclonal antibody and monoclonal antibody to human c-Met were acquired from Santa Cruz Biotechnology (C-28, Santa Cruz, CA, ...
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
Sethi Jaswinder K., In PLoS ONE, 2001
... and HEPES were from Invitrogen (Carlsbad, CA), insulin from Lilly (Suresnes, France), PDGF-BB, IGF-1, and HGF from PeproTech (Rocky Hill, NJ), and 2-[3H]deoxyglucose from PerkinElmer Life (Waltham, MA) ...
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor
Bandyopadhyay Sandip K. et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1999
... EIA kit, nitrate/ nitrite fluorometric assay kit, VEGF and HGF ELISA kits (Cayman Chem., Ann Arbor, MI, ...
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
Brugge Joan S. et al., In The Journal of Cell Biology, 1998
... Antibodies to CSF-1R and c-Met were obtained from Santa Cruz Biotechnology, Inc.; laminin 5 from Chemicon; ...
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
Fisher Elizabeth M. C. et al., In Disease Models & Mechanisms, 1996
... Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS ...
Proteoglycans as modulators of growth factor activities
Pals Steven T. et al., In The Journal of Experimental Medicine, 1990
... Polyclonal antibodies used were rabbit anti–c-Met, C-12 (IgG) (Santa Cruz Biotechnology ...
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