A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types.
Tokyo, Japan. In Clin Transl Med, Dec 2015
70 proteins including HPX, CTTN, CDH1, EGFR, MUC1 were found as LPIA-type marker candidates, 15 protein candidates for MIA-type marker included CRABP2, LMO7, and NPEP, and 26 protein candidates for AIS-type marker included LTA4H and SOD2.
Integration of transcriptome and methylome analysis of aldosterone-producing adenomas.
Tokyo, Japan. In Eur J Endocrinol, Aug 2015
Of these, three genes (CYP11B2, MC2R, and HPX) may be related to aldosterone production, and five genes (PRRX1, RAB38, FAP, GCNT2, and ASB4) are potentially involved in tumorigenesis.
HO-1 expression control in the rat glomerulus.
Athens, Greece. In Biochem Biophys Res Commun, Jun 2015
Following 18 h incubations with hemin (0-200 μM), HO-1 expression increased in a concentration-dependent manner and via a hemopexin (HPX) independent mechanism with no effect on HO-2.
New strategies for targeting matrix metalloproteinases.
Jupiter, United States. In Matrix Biol, May 2015
Small molecules and peptides have been developed that bind exosites in the catalytic (CAT) domain of MMP-13, the CAT or hemopexin-like (HPX) domain of MT1-MMP, and the collagen binding domain (CBD) of MMP-2 and MMP-9.
Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders.
Kansas City, United States. In Front Physiol, 2014
The goal here is to describe our current understanding of heme metabolism and the deleterious effects of "free" heme on immunological processes, endothelial function, systemic inflammation, and various end-organ tissues (e.g., kidney, lung, liver, etc.), with particular attention paid to the role of hemopexin (HPX).
The startle syndromes: physiology and treatment.
Amsterdam, Netherlands. In Epilepsia, 2012
Startle syndromes form a heterogeneous group of disorders with three categories: hyperekplexia (HPX), stimulus-induced disorders, and neuropsychiatric syndromes.
Hemopexin decreases hemin accumulation and catabolism by neural cells.
Philadelphia, United States. In Neurochem Int, 2012
results demonstrate that hemopexin decreases the accumulation and catabolism of exogenous hemin by neural cells. Its beneficial effect in stroke models is unlikely to be mediated by increased production of cytoprotective heme breakdown products