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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hemopexin

Hemopexin, HPX
This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, Haptoglobin, catalase
Papers on Hemopexin
Structure-based drug discovery accelerated by many-core devices.
New
Brylinski et al., Baton Rouge, United States. In Curr Drug Targets, Feb 2016
We also discuss common parallel programming frameworks targeted to this accelerator, including OpenMP, OpenCL, MPI and HPX.
A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types.
New
Kato et al., Tokyo, Japan. In Clin Transl Med, Dec 2015
70 proteins including HPX, CTTN, CDH1, EGFR, MUC1 were found as LPIA-type marker candidates, 15 protein candidates for MIA-type marker included CRABP2, LMO7, and NPEP, and 26 protein candidates for AIS-type marker included LTA4H and SOD2.
Proteomic Profiling of the Respiratory Syncytial Virus-Infected Rat Pneumonia Model.
New
Wang et al., In Jpn J Infect Dis, Oct 2015
The significantly elevated expressions of four proteins T-kininogen 1 (KNT1), T-kininogen 2 (KNT2), haptoglobin (HP), and hemopexin (HPX) were further validated in RSV-infected rats using western blot and immunohistochemistry, which might serve as the potential biomarkers of RSV-infected pneumonia.
[The Effects of the Hemopexin on Generation of Free Radicals and Brain Edema after Intracerebral Hemorrhage].
New
Li et al., In Sichuan Da Xue Xue Bao Yi Xue Ban, Sep 2015
OBJECTIVE: To explore the effects of the Hemopexin (Hx) on the generation of free radicals and brain edema after intracerebral hemorrhage (ICH).
Integration of transcriptome and methylome analysis of aldosterone-producing adenomas.
New
Ogawa et al., Tokyo, Japan. In Eur J Endocrinol, Aug 2015
Of these, three genes (CYP11B2, MC2R, and HPX) may be related to aldosterone production, and five genes (PRRX1, RAB38, FAP, GCNT2, and ASB4) are potentially involved in tumorigenesis.
HO-1 expression control in the rat glomerulus.
New
Lianos et al., Athens, Greece. In Biochem Biophys Res Commun, Jun 2015
Following 18 h incubations with hemin (0-200 μM), HO-1 expression increased in a concentration-dependent manner and via a hemopexin (HPX) independent mechanism with no effect on HO-2.
New strategies for targeting matrix metalloproteinases.
Review
New
Fields, Jupiter, United States. In Matrix Biol, May 2015
Small molecules and peptides have been developed that bind exosites in the catalytic (CAT) domain of MMP-13, the CAT or hemopexin-like (HPX) domain of MT1-MMP, and the collagen binding domain (CBD) of MMP-2 and MMP-9.
[Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP].
New
Mao et al., In Sheng Wu Gong Cheng Xue Bao, Feb 2015
Analysis of the affinities of these five antisense peptides to other MMPs (MMP1-3, MMP7-13, MMP14 HPX, MMP16) revealed that the peptide FVTFPYIR was more specific to MT1-MMP.
Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders.
Biernacka et al., Rochester, United States. In Transl Psychiatry, 2014
After correcting for multiple testing and adjusting for covariates, growth differentiation factor 15 (GDF-15), hemopexin (HPX), hepsin (HPN), matrix metalloproteinase-7 (MMP-7), retinol-binding protein 4 (RBP-4) and transthyretin (TTR) all showed statistically significant differences among groups.
Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders.
Review
McCulloh et al., Kansas City, United States. In Front Physiol, 2014
The goal here is to describe our current understanding of heme metabolism and the deleterious effects of "free" heme on immunological processes, endothelial function, systemic inflammation, and various end-organ tissues (e.g., kidney, lung, liver, etc.), with particular attention paid to the role of hemopexin (HPX).
The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators.
Åkerström et al., Lund, Sweden. In Plos One, 2014
Thus, we have investigated the levels of cell-free HbF (both free, denoted HbF, and in complex with Hp, denoted Hp-HbF) as well as the major human endogenous Hb- and heme-scavenging systems: haptoglobin (Hp), hemopexin (Hpx), α1-microglobulin (A1M) and CD163 in plasma of PE women (n = 98) and women with normal pregnancies (n = 47) at term.
Biophysical studies of matrix metalloproteinase/triple-helix complexes.
Review
Fields, Port Saint Lucie, United States. In Adv Protein Chem Struct Biol, 2013
Structures observed in solution exhibit flexibility between the MMP catalytic (CAT) and hemopexin-like (HPX) domains, while solid-state structures are relatively compact.
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway.
Impact
Werb et al., San Francisco, United States. In Cell Stem Cell, 2013
We show that MMP3 overexpression promotes hyperplastic epithelial growth, surprisingly, in a nonproteolytic manner via its hemopexin (HPX) domain.
[Progress in biochemical characteristics of hemopexin and its clinical application].
Review
Xiong et al., China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2013
Hemopexin (HPX) is a plasma protein with the strongest binding capacity to heme and widely involved in modulation of a variety of physiological and pathological processes.
The startle syndromes: physiology and treatment.
Review
Tijssen et al., Amsterdam, Netherlands. In Epilepsia, 2012
Startle syndromes form a heterogeneous group of disorders with three categories: hyperekplexia (HPX), stimulus-induced disorders, and neuropsychiatric syndromes.
Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation.
GeneRIF
Warren et al., Boston, United States. In J Immunol, 2012
The findings suggest that hemopexin can modulate the role of hemoglobin in sterile and infectious inflammation
Hemopexin is up-regulated in plasma from type 1 diabetes mellitus patients: Role of glucose-induced ROS.
GeneRIF
Chan et al., Taiwan. In J Proteomics, 2012
In conclusion, the current work has identified potential T1DM biomarkers and one of these, hemopexin, can be modulated by glucose through a ROS-dependent mechanism.
Hemopexin decreases hemin accumulation and catabolism by neural cells.
GeneRIF
Regan et al., Philadelphia, United States. In Neurochem Int, 2012
results demonstrate that hemopexin decreases the accumulation and catabolism of exogenous hemin by neural cells. Its beneficial effect in stroke models is unlikely to be mediated by increased production of cytoprotective heme breakdown products
Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin.
GeneRIF
Yoshikawa et al., Kyoto, Japan. In J Gastroenterol Hepatol, 2012
Hemopexin was identified as upregulated protein in the small intestine exposed to indomethacin.
A role for hemopexin in oligodendrocyte differentiation and myelin formation.
GeneRIF
Tolosano et al., Torino, Italy. In Plos One, 2010
Data sugget that Hx may be considered a novel OL differentiation factor and the modulation of its expression in CNS may be an important factor in the pathogenesis of human neurodegenerative disorders.
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