Iron modulates the alpha chain of fibrinogen.
Tucson, United States. In Biometals, Feb 2016
UNASSIGNED: Iron-bound fibrinogen has been noted to accelerate plasmatic coagulation in patients with divergent conditions involving upregulation of heme oxygenase activity, including hemodialysis, Alzheimer's disease, sickle cell anemia, and chronic migraine.
Oxidative stress modulation in hepatitis C virus infected cells.
Monterrey, Mexico. In World J Hepatol, Jan 2016
Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system (GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1.
The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance.
Genova, Italy. In Oxid Med Cell Longev, Dec 2015
Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes such as heme oxygenase 1 (HO-1).
Modulation of neurotrophic signaling pathways by polyphenols.
Shīrāz, Iran. In Drug Des Devel Ther, Dec 2015
Finally, the antioxidant activity of polyphenols reflected in the activation of Nrf2 pathway and the consequent upregulation of detoxification enzymes such as heme oxygenase-1 as well as the contribution of these effects to the neurotrophic activity have also been discussed.
Redox mechanisms of cardiomyocyte mitochondrial protection.
Durham, United States. In Front Physiol, 2014
Coordinated cytoplasmic to nuclear cell-signaling and mitochondrial transcriptional responses to the presence of elevated cytoplasmic oxidant production, e.g., H2O2, allows nuclear translocation of the Nfe2l2 transcription factor and up-regulation of downstream cytoprotective genes such as heme oxygenase-1 which generates physiologic signals, such as CO that up-regulates Nfe212 gene transcription.