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TED4 heme oxygenase 1

heme oxygenase, ho1, hy6
Encodes a plastid heme oxygenase necessary for phytochrome chromophore biosynthesis and for coupling the expression of some nuclear genes to the functional state of the chloroplast. (from NCBI)
Top mentioned proteins: Nrf2, V1a, CAN, Ros, ACID
Papers using heme oxygenase antibodies
Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes.
Pi Jingbo et al., In Environmental Health Perspectives, 2010
... Antibodies for NRF2 (sc-13032; 1:500), KEAP1 (sc-15246; 1:500), NRF1 (sc-13031; 1:500), and heme oxygenase 1 (HMOX-1; sc-136902; 1:500) were purchased from Santa Cruz Biotechnology Inc ...
Selective separation of proteins with pH-dependent magnetic nanoadsorbents
Qin Song et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... ho1 and pcyA genes for the biosynthesis of PCB were ligated ...
A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.
Gendelman Howard E., In PLoS ONE, 1998
... using appropriate primary antibodies (anti-Nrf2, (1∶1000 Epitomics CA); anti-NQO1, anti-glutathione reductase and anti-heme oxygenase-1 (1∶1000 Abcam MA) and anti-β-actin Chemicon ...
Papers on heme oxygenase
Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury.
Signorelli et al., Milano, Italy. In Basic Res Cardiol, Mar 2016
In the area at risk, myriocin downregulated ceramide, reduced the content in other mediators of inflammation and reactive oxygen species, and activated the Nrf2-HO1 cytoprotective response.
Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats.
Dong et al., Xi'an, China. In Fundam Clin Pharmacol, Feb 2016
The protein and mRNA expression of Nrf2 and heme oxygenase-1 (HO-1) in the colon were detected by Western blot and quantitative polymerase chain reaction (qPCR) respectively.
Involvement of Nuclear Related Factor 2 Signaling Pathway in the Brain of Obese Rats and Obesity-Resistant Rats Induced by High-Fat Diet.
Xiao et al., Beijing, China. In J Med Food, Feb 2016
In addition, the protein expression of Nrf2 and its downstream factors such as heme oxygenase 1, manganese superoxide dismutase, and NAD(P)H quinone oxidoreductase 1 (NQO1) in the brain tissue were measured by Western blotting.
Iron modulates the alpha chain of fibrinogen.
Jacobsen et al., Tucson, United States. In Biometals, Feb 2016
UNASSIGNED: Iron-bound fibrinogen has been noted to accelerate plasmatic coagulation in patients with divergent conditions involving upregulation of heme oxygenase activity, including hemodialysis, Alzheimer's disease, sickle cell anemia, and chronic migraine.
Oxidative stress modulation in hepatitis C virus infected cells.
Rivas-Estilla et al., Monterrey, Mexico. In World J Hepatol, Jan 2016
Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system (GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1.
The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance.
Nitti et al., Genova, Italy. In Oxid Med Cell Longev, Dec 2015
Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes such as heme oxygenase 1 (HO-1).
Modulation of neurotrophic signaling pathways by polyphenols.
Firuzi et al., Shīrāz, Iran. In Drug Des Devel Ther, Dec 2015
Finally, the antioxidant activity of polyphenols reflected in the activation of Nrf2 pathway and the consequent upregulation of detoxification enzymes such as heme oxygenase-1 as well as the contribution of these effects to the neurotrophic activity have also been discussed.
Chemical Characterization, Free Radical Scavenging, and Cellular Antioxidant and Anti-Inflammatory Properties of a Stilbenoid-Rich Root Extract of Vitis vinifera.
Rimbach et al., Kiel, Germany. In Oxid Med Cell Longev, Dec 2015
On a cellular level it was observed that the root extract of Vitis vinifera protects against hydrogen peroxide-induced DNA damage and induces Nrf2 and its target genes heme oxygenase-1 and γ-glutamylcysteine synthetase.
The Abdominal Aortic Aneurysm and Intraluminal Thrombus: Current Concepts of Development and Treatment.
Brostjan et al., Vienna, Austria. In Front Cardiovasc Med, 2014
Particular focus is placed on the controversial role of heme oxygenase 1/carbon monoxide and nitric oxide synthase/peroxynitrite, which may exert both protective and damaging effects in the development of the aneurysm.
Redox mechanisms of cardiomyocyte mitochondrial protection.
Piantadosi et al., Durham, United States. In Front Physiol, 2014
Coordinated cytoplasmic to nuclear cell-signaling and mitochondrial transcriptional responses to the presence of elevated cytoplasmic oxidant production, e.g., H2O2, allows nuclear translocation of the Nfe2l2 transcription factor and up-regulation of downstream cytoprotective genes such as heme oxygenase-1 which generates physiologic signals, such as CO that up-regulates Nfe212 gene transcription.
Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin.
Ikeda-Saito et al., Baltimore, United States. In Acc Chem Res, 2014
Thus, in the determination of heme oxygenase activity in vitro, it is important to ensure that the reaction proceeds through successive oxygenation steps.
Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.
Esterbauer et al., Vienna, Austria. In Cell, 2014
Here, we tested a hypothesized anti-inflammatory role for heme oxygenase-1 (HO-1) in the development of metabolic disease.
Mutation of Arabidopsis HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.
Shen et al., Nanjing, China. In J Exp Bot, 2012
Mutation of HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.
Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization.
Riley et al., London, United Kingdom. In Nat Med, 2012
Induction of heme oxygenase-1 (HO-1) mediates tolerance to the cytotoxic effects of heme during malarial hemolysis but might impair resistance to NTS by limiting production of bactericidal reactive oxygen species.
Functional interconnections of HY1 with MYC2 and HY5 in Arabidopsis seedling development.
Chattopadhyay et al., New Delhi, India. In Bmc Plant Biol, 2011
HY1 and HY5 additively regulate the expression of light regulated genes and accumulation of chlorophyll and anthocyanin during early seedling development.
An antioxidant link between sickle cell disease and severe malaria.
Engwerda et al., Australia. In Cell, 2011
(2011) show that carriers of the sickle cell mutation increase expression of the heme oxygenase-1 enzyme, which produces antioxidant molecules that may prevent severe disease symptoms.
Sickle hemoglobin confers tolerance to Plasmodium infection.
Soares et al., Portugal. In Cell, 2011
Sickle Hb induces the expression of heme oxygenase-1 (HO-1) in hematopoietic cells, via a mechanism involving the transcription factor NF-E2-related factor 2 (Nrf2).
Evidence of Arabidopsis salt acclimation induced by up-regulation of HY1 and the regulatory role of RbohD-derived reactive oxygen species synthesis.
Shen et al., Nanjing, China. In Plant J, 2011
HY1 (Heme oxygenase 1) plays an important role in salt acclimation.
Characterization of the haem oxygenase protein family in Arabidopsis thaliana reveals a diversity of functions.
Frankenberg-Dinkel et al., Bochum, Germany. In Biochem J, 2010
all members of the HO1 subfamily (HY1, HO3 and HO4) are active monomeric HOs and can convert haem to BV IXalpha using spinach Fd (ferredoxin) as an electron donor
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