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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hedgehog interacting protein

Hedgehog-interacting protein
Top mentioned proteins: Shh, Smo, Ihh, Gli, CAN
Papers on Hedgehog-interacting protein
Secreted phosphoprotein 1 is a determinant of lung function development in mice.
Leikauf et al., In Am J Respir Cell Mol Biol, 2014
Insulin-like growth factor 1, Hedgehog-interacting protein, wingless-related mouse mammary tumor virus integration site 5A, and NOTCH1 transcripts decreased in the lung of P14 Spp1((-/-)) mice as determined by quantitative RT-PCR analysis.
Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling.
Roelink et al., Berkeley, United States. In Nat Commun, 2013
Several negative feedback mechanisms are in place, including the Shh-induced upregulation of Hedgehog-interacting protein (Hhip).
Glioma stem cells enhance endothelial cell migration and proliferation via the Hedgehog pathway.
Guo et al., Chongqing, China. In Oncol Lett, 2013
The gene expression of the HH pathway-related genes, Sonic Hedgehog (Shh) and Hedgehog-interacting protein (Hhip) was altered in the endothelial cells when co-cultured with GSCs.
Sonic hedgehog regulates its own receptor on postcrossing commissural axons in a glypican1-dependent manner.
Stoeckli et al., Zürich, Switzerland. In Neuron, 2013
Here, we show that the heparan sulfate proteoglycan Glypican1 (GPC1) is required as a coreceptor for the Shh-dependent induction of Hedgehog-interacting protein (Hhip) in commissural neurons.
Chromosome 4q31 locus in COPD is also associated with lung cancer.
Gamble et al., Auckland, New Zealand. In Eur Respir J, 2010
The Hedgehog-interacting protein (HHIP), which mediates the epithelial response (EMT) to smoking, has been implicated in COPD and lung cancer.
Interactions between Hedgehog proteins and their binding partners come into view.
Review
Siebold et al., Stanford, United States. In Genes Dev, 2010
Unraveling the nature and effects of these interactions has proven challenging, but recent structural and biophysical studies of Hh proteins and active fragments of heparin, Ihog, Cdo, Boc, Hedgehog-interacting protein (Hhip), Patched (Ptc), and the monoclonal antibody 5E1 have added a new level of molecular detail to our understanding of how Hh signal response and distribution are regulated within tissues.
Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
Hymowitz et al., San Francisco, United States. In J Biol Chem, 2010
Using biochemical, biophysical, and x-ray crystallographic studies, we show that, like the regulatory receptors Cdon and Hedgehog-interacting protein (Hhip), ch5E1 binding to Sonic hedgehog (Shh) is enhanced by calcium ions.
Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer.
Review
Lazarus et al., San Francisco, United States. In Biol Chem, 2010
For Hh, this region binds to the antagonist receptor Hedgehog-interacting protein (Hhip) and most probably to Ptc1 as well.
Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study.
Stricker et al., Gent, Belgium. In Eur Respir J, 2010
A genome-wide association study has demonstrated that two single nucleotide polymorphisms (SNPs) near the Hedgehog-interacting protein (Hip) gene, SNP identifiers rs1828591 and rs13118928, are associated with risk of chronic obstructive pulmonary disease (COPD).
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Lazarus et al., San Francisco, United States. In Nat Struct Mol Biol, 2009
Hedgehog-interacting protein (Hhip) is a surface receptor antagonist that is equipotent against all three mammalian Hh homologs.
Signal dynamics in Sonic hedgehog tissue patterning.
Schaffer et al., Berkeley, United States. In Development, 2006
Furthermore, several transcriptional targets of Shh, such as Patched and Hedgehog-interacting protein, significantly limit its signaling range by slowing transport and promoting ligand degradation.
Hedgehog signaling pathway and gastric cancer.
Review
Katoh et al., Japan. In Cancer Biol Ther, 2005
Human SHH, IHH, DHH (Hedgehog homologs), HHAT (Hedgehog acyltransferase), HHIP (Hedgehog-interacting protein), DISP1, DISP2, DISP3 (Dispatched homologs), PTCH1, PTCH2 (Patched homologs), SMO (Smoothened homolog), KIF27, KIF7 (Costal-2 homologs), STK36 (Fused homolog), SUFU (SuFu homolog), DZIP1 (Iguana homolog), GLI1, GLI2 and GLI3 (Cubitus interruptus homologs) are implicated in the Hedgehog signaling.
Olfactory and lens placode formation is controlled by the hedgehog-interacting protein (Xhip) in Xenopus.
GeneRIF
Hollemann et al., Göttingen, Germany. In Dev Biol, 2005
Localized expression of Xhip may counteract certain overlapping signaling activities, which inhibit the induction of olfactory and lens placodes.
Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors.
Brooks et al., Richmond, United States. In Bmc Cancer, 2004
Recently a putative antagonist of the pathway, Hedgehog-interacting protein (HIP), was identified as a Hh binding protein that is also a target of Hh signaling.
A freely diffusible form of Sonic hedgehog mediates long-range signalling.
Impact
Robbins et al., Cincinnati, United States. In Nature, 2001
We further demonstrate that the availability of s-ShhNp is regulated by two functional antagonists of the Shh pathway, Patched (Ptc) and Hedgehog-interacting protein (Hip).
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.
Impact
McMahon et al., Cambridge, United States. In Nature, 1999
We have now identified a novel component in the vertebrate signalling pathway, which we name Hip (for Hedgehog-interacting protein) because of its ability to bind Hedgehog proteins.
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