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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

HECT domain containing 2

HECTD2
Top mentioned proteins: Ubiquitin, iMpact, V1a, THRB, Tec
Papers on HECTD2
The proinflammatory role of HECTD2 in innate immunity and experimental lung injury.
New
Chen et al., Pittsburgh, United States. In Sci Transl Med, Aug 2015
We discovered a ubiquitin E3 ligase, HECTD2, which ubiquitinated and mediated the degradation of PIAS1, thus increasing inflammation in an experimental pneumonia model.
MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.
Kantoff et al., Boston, United States. In Oncogene, 2014
By performing systematic biochemical and bioinformatical analyses, we identified two miR-221 targets, HECTD2 and RAB1A, which could mediate the development of CRPC phenotype in multiple prostate cancer cell lines.
Genome wide association studies and prion disease.
Mead et al., London, United Kingdom. In Prion, 2011
Several quantitative trait loci in mouse have been mapped and their human counterparts analysed (HECTD2, CPNE8); other candidate genes regions have been chosen for functional reasons (SPRN, CTSD).
Absence of association between two HECTD2 polymorphisms and sporadic Creutzfeldt-Jakob disease.
GeneRIF
Kim et al., Anyang, South Korea. In Dement Geriatr Cogn Disord, 2010
HECTD2 polymorphisms are not associated with genetic susceptibility to sporadic Creutzfeldt-Jakob disease in a Korean population
Genetics of prion disease.
Review
Collinge et al., London, United Kingdom. In Top Curr Chem, 2010
Several approaches including human genome wide association studies (GWAS), mouse mapping and differential expression studies are now revealing some of these genes which include RARB (retinoic acid receptor beta), the E3 ubiquitin ligase HECTD2 and SPRN (Shadoo, shadow of prion protein gene).
A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse.
Collinge et al., London, United Kingdom. In Neurogenetics, 2010
Whilst quantitative trait loci (QTL) studies have identified multiple loci across the genome, these regions are often large, and with the exception of Hectd2 on Mmu19, no quantitative trait genes or nucleotides for prion disease incubation time have been demonstrated.
HECTD2 is associated with susceptibility to mouse and human prion disease.
GeneRIF
Collinge et al., London, United Kingdom. In Plos Genet, 2009
HECTD2 haplotypes are associated with the susceptibility to human prion diseases.
HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.
GeneRIF
Collinge et al., London, United Kingdom. In Bmc Med Genet, 2008
The common haplotypes of HECTD2, tagged by rs12249854, are not associated with susceptibility to late onset Alzheimer's disease
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