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NDC80 kinetochore complex component homolog

HEC, Ndc80, Hec1
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, Insulin
Papers using HEC antibodies
SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis
Dasso Mary et al., In The Journal of Cell Biology, 2007
... Hec1 monoclonal antibody (9G3) was purchased from Abcam.
Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
Sun Lu-Zhe et al., In Cancer Management and Research, 2006
... One pair of HEC-1-A cells was infected with control pLPCX retrovirus vector (Clontech, Mountain View, CA, USA) ...
TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.
Hardwick Kevin, In PLoS ONE, 2003
... HEC1 cDNA (accession NM_006102) was amplified by PCR and cloned into the pEGFP-C1 vector (BD Biosciences Clontech) ...
NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
Vallee Richard B. et al., In The Journal of Cell Biology, 2002
... Reiner, Weizmann Institute, Rehovot, Israel), monoclonal anti-BUBR1 (BD Biosciences), chicken anti-GFP (Chemicon), monoclonal HEC1 (Abcam), polyclonal anti–ZW10-Cter ( ...
Reversal of vinblastine resistance in human leukemic cells by haloperidol and dihydrohaloperidol
Panda Dulal et al., In BMC Cancer, 2000
... Mouse monoclonal anti-Hec 1 IgG was purchased from Abcam (Cambridge, MA, USA) ...
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Papers on HEC
Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol.
Sreeja et al., Thiruvananthapuram, India. In Iubmb Life, Feb 2016
Our recent research shed light on the possible SERM-like property of methanol extract of pericarp of pomegranate (PME) by using human breast (MCF-7, MDA-MB-231), endometrial (HEC-1A), cervical (SiHa, HeLa), ovarian (SKOV3) cancer cell lines, normal breast fibroblasts (MCF-10A) and also by in vivo models (ovariectomized Swiss albino mice).
Chemotherapy-induced nausea and vomiting: incidence and characteristics of persistent symptoms and future directions NCCTG N08C3 (Alliance).
Barton et al., Rochester, United States. In Support Care Cancer, Feb 2016
METHODS: We recently performed an unplanned secondary analysis on a previously reported negative phase III trial (N08C3) looking at the efficacy of gabapentin/placebo in combination with dexamethasone and a 5HT3 receptor antagonist in the prevention of CINV for 413 patients undergoing regimens with highly emetogenic chemotherapy (HEC).
Epichlorohydrin-Crosslinked Hydroxyethyl Cellulose/Soy Protein Isolate Composite Films as Biocompatible and Biodegradable Implants for Tissue Engineering.
Chen et al., In Acs Appl Mater Interfaces, Feb 2016
UNASSIGNED: A series of epichlorohydrin-crosslinked hydroxyethyl cellulose/soy protein isolate composite films (EHSF) was fabricated from hydroxyethyl cellulose (HEC) and soy protein isolate (SPI) using a process involving blending, crosslinking, solution casting and evaporation.
MicroRNA heterogeneity in endometrial cancer cell lines revealed by deep sequencing.
Ge et al., Nanjing, China. In Oncol Lett, Dec 2015
UNASSIGNED: The aim of the present study was to obtain comprehensive microRNA (miRNA) profiles of type I [Ishikawa (ISK)] and type II (HEC-1B) human endometrial adenocarcinoma cell lines, utilizing the latest high-throughput sequencing techniques.
Novel anti-infective potential of salvianolic acid B against human serious pathogen Neisseria meningitidis.
Tikkanen-Kaukanen et al., Kuopio, Finland. In Bmc Res Notes, Dec 2015
Results were confirmed in a HEC-1B cell dot assay and antimicrobial activity was measured by using a microbroth dilution assay.
Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of cisplatin-based highly emetogenic chemotherapy in patients with cancer: two randomised, active-controlled, double-blind, phase 3 trials.
Navari et al., Johannesburg, South Africa. In Lancet Oncol, Sep 2015
METHODS: We conducted two global, randomised, double-blind, active-controlled, phase 3 trials (HEC-1 and HEC-2) at 155 cancer centres (76 in HEC-1 and 79 in HEC-2) in 26 countries (17 in HEC-1 and 14 in HEC-2).
CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.
Kops et al., Amsterdam, Netherlands. In Science, Jul 2015
We show that the amino-terminal localization module of the SAC protein kinase MPS1 (monopolar spindle 1) directly interacts with the HEC1 (highly expressed in cancer 1) calponin homology domain in the NDC80 (nuclear division cycle 80) kinetochore complex in vitro, in a phosphorylation-dependent manner.
Palonosetron in the prevention of chemotherapy-induced nausea and vomiting: an evidence-based review of safety, efficacy, and place in therapy.
Agustoni et al., Milano, Italy. In Core Evid, 2014
INTRODUCTION: The second-generation 5-hydroxytryptamine-3 (5-HT3) receptor antagonist palonosetron is effective in the prevention of chemotherapy-induced nausea and vomiting (CINV) associated with highly and moderately emetogenic chemotherapy (HEC and MEC, respectively).
Profile of netupitant/palonosetron (NEPA) fixed dose combination and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV).
Navari, Mishawaka, United States. In Drug Des Devel Ther, 2014
NEPA is an oral fixed-dose combination of netupitant and palonosetron which has recently been employed in Phase II and Phase III clinical trials for the prevention of CINV in patients receiving moderately and highly emetogenic chemotherapy (MEC and HEC).
Treatment of Breakthrough and Refractory Chemotherapy-Induced Nausea and Vomiting.
Navari, South Bend, United States. In Biomed Res Int, 2014
Despite significant progress in the prevention of chemotherapy-induced nausea and vomiting (CINV) with the introduction of new antiemetic agents, 30-50% of patients receiving moderately or highly emetogenic chemotherapy (MEC or HEC) and guideline directed prophylactic antiemetics develop breakthrough CINV.
Review of the efficacy of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in a range of tumor types.
Webb et al., Switzerland. In Cancer Treat Rev, 2013
To characterize treatment response in patients with various malignancies (e.g., breast, gastrointestinal, genitourinary, and lung) treated with either highly emetogenic chemotherapy (HEC) or moderately emetogenic chemotherapy (MEC) regimens, a pooled analysis of patient-level data from 4 large randomized trials was performed (N=2813).
Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.
De Wulf et al., Milano, Italy. In Nat Cell Biol, 2012
Cnn1 regulates KMN (KNL1, MIS12 and NDC80 activity in a spatiotemporal manner by inhibiting the interaction between its complexes
CENP-T proteins are conserved centromere receptors of the Ndc80 complex.
Westermann et al., Vienna, Austria. In Nat Cell Biol, 2012
results reveal the molecular function of CENP-T proteins and demonstrate how the Ndc80 complex is anchored to centromeres in a manner that couples chromosome movement to spindle dynamics
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
Cook et al., Chapel Hill, United States. In Nat Cell Biol, 2012
results support the conclusion that Cdt1 binding to Hec1 is essential for an extended Ndc80 configuration and stable kinetochore-microtubule attachment
Palonosetron: an evidence-based choice in prevention of nausea and vomiting induced by moderately emetogenic chemotherapy.
de Braud et al., Milano, Italy. In Tumori, 2012
In two recent meta-analyses, palonosetron was shown to be more effective than other available 5-HT(3) RAs in preventing acute and delayed nausea and vomiting for both HEC and MEC.
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.
Lee et al., Irvine, United States. In Mol Biol Cell, 2011
Hec1 serine 165 (S165) is preferentially phosphorylated at kinetochores by Nek2 and it serves as an important mechanism in modulating spindle assemble checkpoint signaling and chromosome alignment.
A blueprint for kinetochores - new insights into the molecular mechanics of cell division.
Westermann et al., Vienna, Austria. In Nat Rev Mol Cell Biol, 2011
In the past decade, concerted research has resulted in the identification of the individual kinetochore building blocks, the characterization of critical microtubule-interacting components, such as the NDC80 complex, and the development of an approximate model of the architecture of this sophisticated biological machine.
Ndc80 regulates meiotic spindle organization, chromosome alignment, and cell cycle progression in mouse oocytes.
Kim et al., Ch'ŏngju, South Korea. In Microsc Microanal, 2011
Disruption of Ndc80 function by either siRNA injection or antibody injection resulted in severe chromosome misalignment, spindle disruption, and precocious polar body extrusion.
The Ndc80 kinetochore complex forms oligomeric arrays along microtubules.
Nogales et al., Berkeley, United States. In Nature, 2010
subnanometre-resolution cryo-electron microscopy reconstruction of the human Ndc80 complex bound to microtubules
More papers using HEC antibodies
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Fang Guowei et al., In The Journal of Cell Biology, 2000
... monoclonal anti-NEDD1 (Abnova Corporation); anti-GFP clone 3E6 (Invitrogen); anti–γ-tubulin clone GTU-88 (Sigma-Aldrich); CREST (Antibodies, Inc.); anti-Hec1 (GeneTex, Inc.); EB1 (BD Biosciences); ...
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
Kellermayer Miklos S., In PLoS ONE, 1999
... Mouse anti-Hec1 IgG was purchased from Abcam, Cambridge, MA, USA ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... PP1-γ (goat SC-6108; Santa Cruz Biotechnology, Inc.), PP2A (mouse 610555; BD), TPX2 (mouse ab32795; Abcam), Hec1 (mouse GTX70268; GeneTex, Inc.), CenpE (mouse ab5093; ...
Methods for clonal growth and serial cultivation of normal human epidermal keratinocytes and mesothelial cells.
Karl Mike O., In PLoS ONE, 1988
... H3 (P-H3; Upstate Biotechnology), anti-P-Rb (Ser780; Cell Signalling Technology), anti-P-Rb (Ser807-811; Cell Signalling Technology), anti HEC1 (9G3.23;
Chlorpromazines and cancer
Rho Seung Bae et al., In Apoptosis, 1971
... Human cervical (HeLa, C33A and Caski) and endometrial (HEC-1-A and KLE) cancer cell lines were maintained in DMEM (Life Technologies, Gaithersburg, MD) and RPMI1640 ...
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