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NDC80 kinetochore complex component homolog

HEC, Ndc80, Hec1
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] (from NCBI)
Papers using HEC antibodies
SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis
Supplier
Dasso Mary et al., In The Journal of Cell Biology, 2007
... Hec1 monoclonal antibody (9G3) was purchased from Abcam.
Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
Supplier
Sun Lu-Zhe et al., In Cancer Management and Research, 2006
... One pair of HEC-1-A cells was infected with control pLPCX retrovirus vector (Clontech, Mountain View, CA, USA) ...
TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.
Supplier
Hardwick Kevin, In PLoS ONE, 2003
... HEC1 cDNA (accession NM_006102) was amplified by PCR and cloned into the pEGFP-C1 vector (BD Biosciences Clontech) ...
NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
Supplier
Vallee Richard B. et al., In The Journal of Cell Biology, 2002
... Reiner, Weizmann Institute, Rehovot, Israel), monoclonal anti-BUBR1 (BD Biosciences), chicken anti-GFP (Chemicon), monoclonal HEC1 (Abcam), polyclonal anti–ZW10-Cter ( ...
Reversal of vinblastine resistance in human leukemic cells by haloperidol and dihydrohaloperidol
Supplier
Panda Dulal et al., In BMC Cancer, 2000
... Mouse monoclonal anti-Hec 1 IgG was purchased from Abcam (Cambridge, MA, USA) ...
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Papers on HEC
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
Impact
GeneRIF
Cook et al., Chapel Hill, United States. In Nat Cell Biol, 2012
results support the conclusion that Cdt1 binding to Hec1 is essential for an extended Ndc80 configuration and stable kinetochore-microtubule attachment
Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.
Impact
GeneRIF
De Wulf et al., Milano, Italy. In Nat Cell Biol, 2012
Cnn1 regulates KMN (KNL1, MIS12 and NDC80 activity in a spatiotemporal manner by inhibiting the interaction between its complexes
CENP-T proteins are conserved centromere receptors of the Ndc80 complex.
Impact
GeneRIF
Westermann et al., Vienna, Austria. In Nat Cell Biol, 2012
results reveal the molecular function of CENP-T proteins and demonstrate how the Ndc80 complex is anchored to centromeres in a manner that couples chromosome movement to spindle dynamics
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.
GeneRIF
Lee et al., Irvine, United States. In Mol Biol Cell, 2011
Hec1 serine 165 (S165) is preferentially phosphorylated at kinetochores by Nek2 and it serves as an important mechanism in modulating spindle assemble checkpoint signaling and chromosome alignment.
Ndc80 regulates meiotic spindle organization, chromosome alignment, and cell cycle progression in mouse oocytes.
GeneRIF
Kim et al., Ch'ŏngju, South Korea. In Microsc Microanal, 2011
Disruption of Ndc80 function by either siRNA injection or antibody injection resulted in severe chromosome misalignment, spindle disruption, and precocious polar body extrusion.
More papers using HEC antibodies
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 2000
... monoclonal anti-NEDD1 (Abnova Corporation); anti-GFP clone 3E6 (Invitrogen); anti–γ-tubulin clone GTU-88 (Sigma-Aldrich); CREST (Antibodies, Inc.); anti-Hec1 (GeneTex, Inc.); EB1 (BD Biosciences); ...
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
Supplier
Kellermayer Miklos S., In PLoS ONE, 1999
... Mouse anti-Hec1 IgG was purchased from Abcam, Cambridge, MA, USA ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... PP1-γ (goat SC-6108; Santa Cruz Biotechnology, Inc.), PP2A (mouse 610555; BD), TPX2 (mouse ab32795; Abcam), Hec1 (mouse GTX70268; GeneTex, Inc.), CenpE (mouse ab5093; ...
Methods for clonal growth and serial cultivation of normal human epidermal keratinocytes and mesothelial cells.
Supplier
Karl Mike O., In PLoS ONE, 1988
... H3 (P-H3; Upstate Biotechnology), anti-P-Rb (Ser780; Cell Signalling Technology), anti-P-Rb (Ser807-811; Cell Signalling Technology), anti HEC1 (9G3.23;
Chlorpromazines and cancer
Supplier
Rho Seung Bae et al., In Apoptosis, 1971
... Human cervical (HeLa, C33A and Caski) and endometrial (HEC-1-A and KLE) cancer cell lines were maintained in DMEM (Life Technologies, Gaithersburg, MD) and RPMI1640 ...
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