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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

High density lipoprotein binding protein

vigilin, HDL-binding protein, Vgl
The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HDL, CAN, ACID, STEP, fibrillin-1
Papers on vigilin
Disruption of human vigilin impairs chromosome condensation and segregation.
New
Qin et al., Chengdu, China. In Cell Biol Int, Nov 2015
Human vigilin, a multi-KH-domain nucleic acid-binding protein, is associated with alpha satellites of centromeres.
[Segment Cloning and Expression of Human VIGILIN Gene].
New
Qin et al., In Sichuan Da Xue Xue Bao Yi Xue Ban, Sep 2015
OBJECTIVE: To investigate the mechanisms of interaction between high-density lipoprotein binding protein (HDLBP)-VIGILIN with other proteins, we cloned VIGILIN cDNA N, KH1-7, KH8-12, KH13-14, and C fragments separately into expression vector, and identify the expressed proteins.
Severe hypertriglyceridemia in a patient heterozygous for a lipoprotein lipase gene allele with two novel missense variants.
New
Demuth et al., Berlin, Germany. In Eur J Hum Genet, Sep 2015
They are located in the carboxy-terminal domain of lipoprotein lipase that interacts with the glycosylphosphatidylinositol-anchored HDL-binding protein (GPIHBP1) and are likely of functional relevance.
Less is More-Optimization of DNA Extraction from Canine Feces.
New
Wictum et al., Davis, United States. In J Forensic Sci, Aug 2015
The greatest yield of intact DNA was obtained using a modified silica matrix extraction protocol (VGL-Fecal) on 30-50 mg of fecal matter collected from the external surface of a stool that had been dried for 24 h.
Genetic predisposition of human plasma triglyceride concentrations.
Vrablik et al., Praha, Czech Republic. In Physiol Res, 2014
Rare mutations (mainly in the lipoprotein lipase and apolipoprotein C2) along with common polymorphisms (within apolipoprotein A5, glucokinase regulatory protein, apolipoprotein B, apolipo-protein E, cAMP responsive element binding protein 3-like 3, glycosylphosphatidylinositol-anchored HDL-binding protein 1) play an important role in determining plasma TG levels.
Investigation of effect of 17α-ethinylestradiol on vigilin expression using an isolated recombinant antibody.
Dai et al., Wuhan, China. In Aquat Toxicol, 2014
Vigilin, a highly conserved protein from yeast to mammals, is a multifunctional protein in eukaryotic organisms.
High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis.
Young et al., Oxford, United Kingdom. In J Lipid Res, 2014
NanoSIMS imaging provided evidence of defective transport of lipids from the plasma LPs to adipocytes and cardiomyocytes in mice deficient in glycosylphosphatidylinositol-anchored HDL binding protein 1.
Human somatic cell mutagenesis creates genetically tractable sarcomas.
Impact
Khokha et al., Toronto, Canada. In Nat Genet, 2014
We identified HDLBP, which encodes the RNA-binding protein vigilin, as a candidate tumor suppressor deleted at 2q37.3 in greater than one out of ten tumors across multiple tissues of origin.
Vigilin interacts with CCCTC-binding factor (CTCF) and is involved in CTCF-dependent regulation of the imprinted genes Igf2 and H19.
Qin et al., Chengdu, China. In Febs J, 2014
By yeast two-hybrid screening, we identified vigilin, a multi-KH-domain protein, as a new partner of CTCF.
Vigilin is overexpressed in hepatocellular carcinoma and is required for HCC cell proliferation and tumor growth.
Qin et al., Chengdu, China. In Oncol Rep, 2014
Vigilin contains multiple KH domains and is an evolutionarily conserved RNA-binding protein from yeast to the human.
[Expression of vigilin in cell lines and human hepatocellular carcinoma].
GeneRIF
Qin et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2011
Vigilin may have a relationship with hepatocellular carcinoma progression and proliferation.
Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer.
GeneRIF
Chambers et al., Tucson, United States. In Mol Cell Biol, 2011
identified a competition for binding the 69-nt sequence, through which vigilin and HuR exert opposing effects on c-fms expression, suggesting a role for vigilin in suppression of breast cancer progression
Triglyceride lipases and atherosclerosis.
Review
Olivecrona et al., Umeå, Sweden. In Curr Opin Lipidol, 2010
RECENT FINDINGS: Understanding of LPL action has taken major steps with the discovery of lipase maturation factor 1 as a specific endoplasmic reticulum chaperon needed for proper folding of the lipases, glycosylphosphatidylinositol-anchored HDL-binding protein 1 as an endothelial cell protein needed for transport and binding of LPL and some angiopoietin-like proteins that can modulate LPL activity.
[VIGILIN involves in regulation of imprinting gene IGF2 and H19 in human hepatocellular carcinoma cell].
GeneRIF
Qin et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2009
Expression profiles of human VIGILIN, H19, and IGF2 mRNA increased with cell-cycle prograssion.
On the mechanism of induction of heterochromatin by the RNA-binding protein vigilin.
GeneRIF
Carmichael et al., Farmington, United States. In Rna, 2008
C-terminal domain of human vigilin binds to the histone methyltransferase SUV39H1 in vivo;a new model for vigilin-mediated, RNA-induced gene silencing is presented.
Heterochromatin: on the ADAR radar?
Review
Birchler et al., Columbia, United States. In Curr Biol, 2005
Vigilin proteins, the absence of which is known to cause abnormalities in heterochromatin, have been found to bind edited RNAs.
The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis.
Review
Catterall et al., Seattle, United States. In Sci Stke, 2004
Complex multicellular organisms require rapid and accurate transmission of information among cells and tissues and tight coordination of distant functions.
Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain.
GeneRIF
Kruse et al., Lübeck, Germany. In Int J Biochem Cell Biol, 2004
evidence that vigilin is bound to the ribosomal complex.
Vitamin E as an antioxidant of the lung: mechanisms of vitamin E delivery to alveolar type II cells.
Review
Rüstow et al., Berlin, Germany. In Am J Respir Crit Care Med, 2003
The uptake of vitamin E by specific lipid transfer is mediated by at least three HDL-specific receptors (scavenger receptor BI, membrane dipeptidase, and HDL-binding protein-2).
Regulation of pathways of mRNA destabilization and stabilization.
Review
Shapiro et al., Urbana, United States. In Prog Nucleic Acid Res Mol Biol, 2001
As a potential example of this type of control, we focus on the regulated degradation of the egg yolk precursor protein vitellogenin on the mRNA-binding protein vigilin and the mRNA endonuclease polysomal ribonuclease 1 (PMR-1).
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