Essential role of HDAC6 in the regulation of PD-L1 in melanoma.
Fort Lee, United States. In Mol Oncol, Feb 2016
In this context, our present work demonstrates that the pharmacological or genetic abrogation of HDAC6 in primary melanoma samples and cell lines, down-regulates the expression of PD-L1, an important co-stimulatory molecule expressed in cancer cells, which activates the inhibitory regulatory pathway PD-1 in T-cells.
Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases.
Philadelphia, United States. In Gene, Sep 2015
Downstream, NEDD9 regulation of partners including CRKL, WAVE, PI3K/AKT, ERK, E-cadherin, Aurora-A (AURKA), HDAC6, and others allow NEDD9 to influence functions as pleiotropic as migration, invasion, survival, ciliary resorption, and mitosis.