HDAC3 mediates smoking-induced pancreatic cancer.
Los Angeles, United States. In Oncotarget, Feb 2016
It further demonstrates that targeting HDAC3 prevents progression of the disease and could provide a strategy for treating the disease considering that the HDAC inhibitor we used is FDA approved for a different disease.
Non-sirtuin histone deacetylases in the control of cardiac aging.
Aurora, United States. In J Mol Cell Cardiol, Jun 2015
Emerging data have revealed numerous mechanisms by which HDAC inhibitors benefit the heart, including suppression of oxidative stress and inflammation, inhibition of MAP kinase signaling, and enhancement of cardiac protein aggregate clearance and autophagic flux.
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.
Philadelphia, United States. In Nature, 2014
Here we demonstrate that mice with an intestinal epithelial cell (IEC)-specific deletion of the epigenome-modifying enzyme histone deacetylase 3 (HDAC3(ΔIEC) mice) exhibited extensive dysregulation of IEC-intrinsic gene expression, including decreased basal expression of genes associated with antimicrobial defence.