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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Histone deacetylase 3

HDAC3, histone deacetylase 3, HD3
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, HDAC, CYP3A4, HDAC2, CAN
Papers using HDAC3 antibodies
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
Supplier
Nielsen Torsten O. et al., In Sarcoma, 2006
... siRNA targeting HDAC3 was obtained from Santa Cruz Biotechnology (Santa Cruz, Calif, USA), ...
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain
Supplier
Casaccia-Bonnefil Patrizia et al., In The Journal of Cell Biology, 2002
... WB; Affinity BioReagents, Inc.); HDAC2 (1:100 for IHC, 1:1,000 for WB; Santa Cruz Biotechnology, Inc.); HDAC3 (1:100 for IHC, 1:500 for WB; Santa Cruz Biotechnology, Inc.); HDAC4 (1:100 for ...
Papers on HDAC3
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model.
New
Artico et al., Padova, Italy. In Autoimmunity, Feb 2016
Initially proposed for cancer therapy, recently the interest for HDAC inhibitors (HDACi) as orally active, safe, and anti-inflammatory agents is rising due to their ability in reducing the severity of inflammatory and autoimmune diseases.
Epigenetic Regulation of the Blimp-1 Gene in B Cells Involves Bach2 and Histone Deacetylase 3.
New
Igarashi et al., Japan. In J Biol Chem, Feb 2016
Purification of Bach2 complex in BAL17 cells revealed its interaction with histone deacetylase 3 (HDAC3), nuclear co-repressors NCoR1 and NCoR2, transducin beta-like 1X-linked (Tbl1x), and RAP1 interacting factor homolog (Rif1).
Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.
New
Xu et al., Nanjing, China. In Cell Rep, Feb 2016
Here, we show that histone deacetylase 3 (HDAC3) is a critical component of the circadian negative feedback loop by regulating both the activation and repression processes in a deacetylase activity-independent manner.
Cellular functions of programmed cell death 5.
Review
New
Chen et al., Beijing, China. In Biochim Biophys Acta, Feb 2016
PDCD5 regulates the activities of TIP60, HDAC3, MDM2 and TP53 transcription factors.
HDAC3 mediates smoking-induced pancreatic cancer.
New
Pandol et al., Los Angeles, United States. In Oncotarget, Feb 2016
It further demonstrates that targeting HDAC3 prevents progression of the disease and could provide a strategy for treating the disease considering that the HDAC inhibitor we used is FDA approved for a different disease.
Practical prospects for boosting hepatic production of the "pro-longevity" hormone FGF21.
New
McCarty, In Horm Mol Biol Clin Investig, Jan 2016
Conversely, histone deacetylase 3 (HDAC3) inhibits PPARα's transcriptional impact on FGF21, and type 1 deacetylase inhibitors such as butyrate therefore increase FGF21 expression.
Dissecting the Rev-erbα Cistrome and the Mechanisms Controlling Circadian Transcription in Liver.
Review
New
Lazar et al., Philadelphia, United States. In Cold Spring Harb Symp Quant Biol, Oct 2015
Oscillation of clock genes was enforced by direct competition between Rev-erbα and RORα for binding to cognate motifs in the genome, whereas metabolic CCGs were governed by recruitment of the NCoR/HDAC3 complex to enhancers where Rev-erbα is tethered by tissue-specific TFs.
GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock.
New
Impact
Lazar et al., Philadelphia, United States. In Science, Jul 2015
By contrast, Rev-erbα regulates metabolic genes primarily by recruiting the HDAC3 co-repressor to sites to which it is tethered by cell type-specific transcription factors.
Non-sirtuin histone deacetylases in the control of cardiac aging.
Review
New
McKinsey et al., Aurora, United States. In J Mol Cell Cardiol, Jun 2015
Emerging data have revealed numerous mechanisms by which HDAC inhibitors benefit the heart, including suppression of oxidative stress and inflammation, inhibition of MAP kinase signaling, and enhancement of cardiac protein aggregate clearance and autophagic flux.
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.
New
Impact
Guttman et al., Pasadena, United States. In Nature, Jun 2015
We show that SHARP, which interacts with the SMRT co-repressor that activates HDAC3, is not only essential for silencing, but is also required for the exclusion of RNA polymerase II (Pol II) from the inactive X.
The Hyaluronic Acid-HDAC3-miRNA Network in Allergic Inflammation.
Review
Jeoung et al., Ch'unch'ŏn, South Korea. In Front Immunol, 2014
We reported regulatory role of HA in the expression of HDAC3.
An epigenetic regulator: methyl-CpG-binding domain protein 1 (MBD1).
Review
Chan et al., Hong Kong, Hong Kong. In Int J Mol Sci, 2014
MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex.
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.
Impact
Artis et al., Philadelphia, United States. In Nature, 2014
Here we demonstrate that mice with an intestinal epithelial cell (IEC)-specific deletion of the epigenome-modifying enzyme histone deacetylase 3 (HDAC3(ΔIEC) mice) exhibited extensive dysregulation of IEC-intrinsic gene expression, including decreased basal expression of genes associated with antimicrobial defence.
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.
Impact
Lee et al., Boston, United States. In Nature, 2013
In mice, this program follows a circadian rhythm that peaks with nocturnal feeding and is repressed by Rev-erbα/β and an HDAC3-containing complex during the day.
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.
Impact
Glass et al., San Diego, United States. In Nature, 2013
Rev-Erbs function as transcriptional repressors by recruiting nuclear receptor co-repressor (NCoR)-HDAC3 complexes to Rev-Erb response elements in enhancers and promoters of target genes, but the molecular basis for cell-specific programs of repression is not known.
Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells.
GeneRIF
Skawran et al., Hannover, Germany. In Gastroenterology, 2012
In hepatocellular carcinoma cells, up-regulation of HDAC1-3 reduces expression of miR-449, activating hepatocyte growth factor and altering tumor growth.
Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.
GeneRIF
Jeoung et al., South Korea. In J Biol Chem, 2012
Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein
Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.
GeneRIF
Riley et al., London, United Kingdom. In Circ Res, 2012
Prox1 recruits the corepressor HDAC3 to directly repress Nkx2.5 via a proximal upstream enhancer as a mechanism for regulating Nkx2.5 function in adult cardiac conduction.
The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity.
GeneRIF
Holaska et al., Chicago, United States. In J Biol Chem, 2012
emerin facilitates repressive chromatin formation at the nuclear periphery by increasing the catalytic activity of HDAC
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.
Impact
GeneRIF
Lazar et al., Philadelphia, United States. In Nat Med, 2012
establish Hdac3 as a pivotal epigenomic modifier that integrates signals from the circadian clock in the regulation of hepatic intermediary metabolism
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