Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
In PLoS ONE, 2005
... endothelial growth factor (VEGF, Santa Cruz Biotechnology), thrombospondin -1 (TSP-1) (Lab Vision, Fremont, CA, USA), HDAC2 (Abcam, Cambridge, UK), and actin ...
Molecular control of CD4(+) T cell lineage plasticity and integrity.
Vienna, Austria. In Int Immunopharmacol, Oct 2015
Moreover, the analysis of mice with a conditional deletion of the transcription factor ThPOK or the histone deacetylases HDAC1 and HDAC2 indicated that CD8 lineage genes are actively repressed in CD4(+) T cells in order to maintain the lineage integrity of helper T cells.
Microsatellite instability: an update.
Kawasaki, Japan. In Arch Toxicol, Jun 2015
Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype.
Histone deacetylases in memory and cognition.
Cambridge, United States. In Sci Signal, 2015
In particular, we focus on HDAC2, which plays a central role in coupling lysine acetylation to synaptic plasticity and mediates many of the effects of HDAC inhibition in cognition and disease.
Chromatin repressive complexes in stem cells, development, and cancer.
Copenhagen, Denmark. In Cell Stem Cell, 2014
Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer.