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Histone deacetylase 9

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using HDAC antibodies
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling.
Defossez Pierre-Antoine, In PLoS ONE, 2008
... brain region was analyzed by SDS-PAGE, transferred to PVDF membrane, and detected by immunoblotting using anti-HDAC-2 (Abcam ab7029), and reprobed with ...
Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation
Jou Ilo et al., In Journal of Neuroinflammation, 2008
... Antibodies against phospho-JNK, phospho-MKP-1 and histone deacetylase (HDAC)1 were purchased from Cell Signaling (Beverly, MA) ...
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
Nelson Jay A., In PLoS Pathogens, 2003
... The use of the histone deacetylase (HDAC) inhibitor, trichostatin A (TSA) (Cell Signaling Technologies) in HCMV replication ...
Mechanism of steroid action and resistance in inflammation: Corticoisteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma
Zhang Xianzhi et al., In Journal of Inflammation (London, England), 2002
... Louis, MO, USA), Z-VE(OMe)ID(OMe)-FMK, Z-D(OMe)QMD(OMe)-FMK, IETD-CHO, Q-VD-OPh and LY294002 (Calbiochem, San Diego, USA), HDAC colorimetric activity kit (Biomol, Plymouth Meeting, USA), mometasone ...
Regulation of BRCA1 expression by the Rb-E2F pathway
Dimitroulakos Jim et al., In Cancer Cell International, 1999
... the pharmacy at the Ottawa Hospital Regional Cancer Centre) alone, and in combination with the HDAC inhibitor M344 (Biovision, Mountain View, CA) at ...
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Papers on HDAC
Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism.
Yamamoto et al., Sendai, Japan. In Cell, 2012
Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a), which demasculinizes them.
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
Markus et al., Oxford, United Kingdom. In Nat Genet, 2012
We identified a new association for large vessel stroke within HDAC9 on chromosome 7p21.1.
HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA).
Ali et al., Marseille, France. In Pancreatology, 2012
LBH589 and TSA may translationally regulate some HDAC encoding genes in pancreatic tumors.
Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness.
N├Âthen et al., Bonn, Germany. In Br J Dermatol, 2011
The results show that hdac9 is the third androgenic alopecia susceptibility gene
Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila.
Scott et al., Palmerston North, New Zealand. In Plos One, 2010
The dose of Rpd3 is critical for normal long-term memory.
More papers using HDAC antibodies
Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia.
Herman Christophe, In PLoS ONE, 1997
... The specific LSD1 inhibitor tranylcypromine and histone deacetylase (HDAC) inhibitor trichostatin A (TSA) were purchased from Biomol International LP (Plymouth Meeting, ...
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