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Histone deacetylase 9

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, ACID, CYP3A4, V1a
Papers using HDAC antibodies
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling.
Defossez Pierre-Antoine, In PLoS ONE, 2008
... brain region was analyzed by SDS-PAGE, transferred to PVDF membrane, and detected by immunoblotting using anti-HDAC-2 (Abcam ab7029), and reprobed with ...
Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation
Jou Ilo et al., In Journal of Neuroinflammation, 2008
... Antibodies against phospho-JNK, phospho-MKP-1 and histone deacetylase (HDAC)1 were purchased from Cell Signaling (Beverly, MA) ...
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
Nelson Jay A., In PLoS Pathogens, 2003
... The use of the histone deacetylase (HDAC) inhibitor, trichostatin A (TSA) (Cell Signaling Technologies) in HCMV replication ...
Mechanism of steroid action and resistance in inflammation: Corticoisteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma
Zhang Xianzhi et al., In Journal of Inflammation (London, England), 2002
... Louis, MO, USA), Z-VE(OMe)ID(OMe)-FMK, Z-D(OMe)QMD(OMe)-FMK, IETD-CHO, Q-VD-OPh and LY294002 (Calbiochem, San Diego, USA), HDAC colorimetric activity kit (Biomol, Plymouth Meeting, USA), mometasone ...
Regulation of BRCA1 expression by the Rb-E2F pathway
Dimitroulakos Jim et al., In Cancer Cell International, 1999
... the pharmacy at the Ottawa Hospital Regional Cancer Centre) alone, and in combination with the HDAC inhibitor M344 (Biovision, Mountain View, CA) at ...
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Papers on HDAC
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model.
Artico et al., Padova, Italy. In Autoimmunity, Feb 2016
Initially proposed for cancer therapy, recently the interest for HDAC inhibitors (HDACi) as orally active, safe, and anti-inflammatory agents is rising due to their ability in reducing the severity of inflammatory and autoimmune diseases.
Histone acetylation and reactive oxygen species are involved in the preprophase arrest induced by sodium butyrate in maize roots.
Li et al., Wuhan, China. In Protoplasma, Feb 2016
To study the relationship between histone acetylation and cell cycle progression in plants, sodium butyrate (NaB), a histone deacetylase (HDAC) inhibitor that can cause a significant increase in histone acetylation in both mammal and plant genomes, was applied to treat maize seedlings.
HDAC and NF-κB mediated cytotoxicity Induced by novel N-Chloro β-lactams and benzisoxazole derivatives.
Sivakumar et al., Vellore, India. In Chem Biol Interact, Feb 2016
In silico studies of the compounds with cancer drug target enzymes showed the inhibition of HDAC (Histone Deacetylase) and NF-êB (nuclear factor kappa-light-chain-enhancer of activated B cells) significantly.
Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus.
Berger et al., Philadelphia, United States. In Science, Feb 2016
Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner.
Keeping up the balance: Role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation.
Brundel et al., Groningen, Netherlands. In Cardiovasc Res, Jan 2016
In addition, the therapeutic potential of HDAC inhibition to maintain a healthy proteostasis resulting in a delay in AF onset and progression is discussed.
Enhancement of human sodium iodide symporter gene therapy for breast cancer by HDAC inhibitor mediated transcriptional modulation.
De et al., Mumbai, India. In Sci Rep, Dec 2015
Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo.
Histone deacetylase inhibitors in castration-resistant prostate cancer: molecular mechanism of action and recent clinical trials.
Lin et al., San Antonio, United States. In Ther Adv Urol, Dec 2015
The histone deacetylase (HDAC) family of enzymes limits the expression of genomic regions by improving binding between histones and the DNA backbone.
Overcoming Barriers in Oncolytic Virotherapy with HDAC Inhibitors and Immune Checkpoint Blockade.
Rommelaere et al., Heidelberg, Germany. In Viruses, Dec 2015
In this review, we consider the use of histone deacetylase (HDAC) inhibitors as a means of boosting virus replication and lessening the negative impact of innate immunity on the direct oncolytic effect.
Profiling technologies for the identification and characterization of small-molecule histone deacetylase inhibitors.
Liao, Gainesville, United States. In Drug Discov Today Technol, Nov 2015
Highly sensitive in vitro and cell-based profiling technologies have been developed to discover HDAC inhibitors (HDACi) and characterize their inhibitory potency, target-binding specificity and kinetics.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
Siveke et al., Stanford, United States. In Nat Med, Oct 2015
The histone deacetylase (HDAC) inhibitor SAHA synergizes with JQ1 to augment cell death and more potently suppress advanced PDAC.
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.
Distler et al., Erlangen, Germany. In Nat Med, Feb 2015
NR4A1 recruits a repressor complex comprising SP1, SIN3A, CoREST, LSD1, and HDAC1 to TGF-β target genes, thereby limiting pro-fibrotic TGF-β effects.
Epigenetic treatment of solid tumours: a review of clinical trials.
Codacci-Pisanelli et al., Latina, Italy. In Clin Epigenetics, 2014
We divided compounds in demethylating agents and HDAC inhibitors.
Role of heme oxygenase-1 in demethylating effects on SKM-1 cells induced by decitabine.
Fang et al., Guiyang, China. In Genet Mol Res, 2014
The expressions of p16, p15, TP73, CDH1, ESR1, and PDLIM4 mRNAs were detected by real-time PCR, and those of HO-1, DNMT1, DNMT3A, DNMT3B, HDAC, and p15 proteins were measured by western blot.
Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.
Dynlacht et al., New York City, United States. In Nat Cell Biol, 2014
Foxk1/2 specifically recruits Sin3A-HDAC complexes to restrict acetylation of histone H4 and expression of critical autophagy genes.
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.
Johnstone et al., Melbourne, Australia. In Nat Rev Drug Discov, 2014
We highlight the development of small-molecule HDAC inhibitors and their use in the laboratory, in preclinical models and in the clinic.
Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism.
Yamamoto et al., Sendai, Japan. In Cell, 2012
Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a), which demasculinizes them.
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
Markus et al., Oxford, United Kingdom. In Nat Genet, 2012
We identified a new association for large vessel stroke within HDAC9 on chromosome 7p21.1.
HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA).
Ali et al., Marseille, France. In Pancreatology, 2012
LBH589 and TSA may translationally regulate some HDAC encoding genes in pancreatic tumors.
Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness.
Nöthen et al., Bonn, Germany. In Br J Dermatol, 2011
The results show that hdac9 is the third androgenic alopecia susceptibility gene
Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila.
Scott et al., Palmerston North, New Zealand. In Plos One, 2010
The dose of Rpd3 is critical for normal long-term memory.
More papers using HDAC antibodies
Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia.
Herman Christophe, In PLoS ONE, 1997
... The specific LSD1 inhibitor tranylcypromine and histone deacetylase (HDAC) inhibitor trichostatin A (TSA) were purchased from Biomol International LP (Plymouth Meeting, ...
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