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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Defensin, alpha 5, Paneth cell-specific

HD5, defensin 5, alpha-defensin 5, DEFA5
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Defensin, HD6, HAD, POLYMERASE, CAN
Papers on HD5
Unmethylated CpG motifs in Toxoplasma gondii DNA induce TLR9- and IFN-β-dependent expression of α-defensin-5 in intestinal epithelial cells.
New
Corral et al., Santander, Spain. In Parasitology, Jan 2016
We herein aimed to examine the molecular mechanism by which protozoan DNA boosts the production of α-defensin-5 (DEFA-5), the main antimicrobial peptide at the target site of infection.
Activity of Genital Tract Secretions and Synthetic Antimicrobial Peptides against Group B Streptococcus.
New
Ghartey et al., United States. In Am J Reprod Immunol, Dec 2015
The human neutrophil peptide-1 and human defensin 5 inhibited GBS growth by ≥80% at concentrations ≥20 μg/mL and ≥50 μg/mL, respectively, while human beta-defensin 2 and LL-37 did not inhibit at highest concentration tested (100 μg/mL).
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis.
Review
New
Rubio, Stockholm, Sweden. In Anticancer Res, Dec 2015
To by-pass the tough microenvironment, the epithelia of the GI react by speeding-up cell exfoliation, by increasing peristalsis, eliminating bacteria through secretion of plasma cell-immunoglobulins and by increasing production of natural antibacterial enzymes (lysozyme) and host defense peptides (defensin-5).
Functional synergism of Human Defensin 5 and Human Defensin 6.
New
de Leeuw et al., Baltimore, United States. In Biochem Biophys Res Commun, Dec 2015
In humans, specialized epithelial cells, termed Paneth cells, located primarily in the small intestine express two defensins, Human Defensin-5 (HD-5) and Human Defensin-6 (HD-6).
HD5 and HBD1 variants' solvation potential energy correlates with their antibacterial activity against escherichia coli.
New
Alencar et al., Brasília, Brazil. In Biopolymers, Dec 2015
It is known that point mutations in HD5 and HBD1 could modify their activities; however, these mutations do not seem to alter their three-dimensional structures.
Crohn's disease-derived monocytes fail to induce Paneth cell defensins.
New
Wehkamp et al., Tübingen, Germany. In Proc Natl Acad Sci U S A, Dec 2015
Paneth cells reside in the small intestine and produce antimicrobial peptides essential for the host barrier, principally human α-defensin 5 (HD5) and HD6.
Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins.
Impact
Kudryashov et al., Columbus, United States. In Immunity, 2014
HD5 and ?-defensin hBD2 shared similar toxin-unfolding effects with HNP1, albeit to different degrees.
Antimicrobial proteins in intestine and inflammatory bowel diseases.
Review
Kim, Seoul, South Korea. In Intestinal Res, 2014
In contrast, some AMPs, including human α-defensin 5-6 and human β-defensin 1, are constitutively expressed without microbial contact or invasion.
The Natural Antimicrobial Enzyme Lysozyme is Up-Regulated in Gastrointestinal Inflammatory Conditions.
Review
Rubio, Stockholm, Sweden. In Pathogens, 2013
To counteract the hostile microenvironment, the GI epithelia react by speeding cell exfoliation (the GI mucosa has a turnover time of two to three days), by increasing peristalsis, by eliminating bacteria through secretion of plasma cell-immunoglobulins and by increasing production of natural antibacterial compounds, such as defensin-5 and lysozyme.
Innate immune functions of α-defensins in the small intestine.
Review
Bevins, Davis, United States. In Dig Dis, 2012
Human Paneth cells make two α-defensins: HD5 and HD6.
Role of defensins and cathelicidin LL37 in auto-immune and auto-inflammatory diseases.
Review
Lande et al., Roma, Italy. In Curr Pharm Biotechnol, 2012
In particular, we refer to the human alpha-defensins called human neutrophil peptides (HNP1 through 4), which are produced by neutrophils, HD5 and HD6, mainly expressed in Paneth cells of intestine, the human beta-defensins HBD1, HBD2 and HBD3, synthesized by epithelial cells and LL37, which is located in granulocytes, but is also produced by epithelial cells of the skin, lungs, and gut.
Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.
GeneRIF
Lu et al., Baltimore, United States. In J Biol Chem, 2012
structural analysis of human enteric alpha-defensin HD5 shows a crucial role for hydrophobicity at the dimer interface
Expression and structure/function relationships of human defensin 5.
GeneRIF
Froy et al., Jerusalem, Israel. In Appl Biochem Biotechnol, 2012
Several arginine residues and tyrosine 27 are important for HD-5 antibacterial activity.
Efficiency of antimicrobial defense: molecular flexibility of natural defensin and artificial bis-quaternary ammonium compound.
GeneRIF
Hori et al., Suzuka, Japan. In Anticancer Res, 2011
The hydrophobicity of regions 2, 9 & 10 was higher than in other regions. It was difficult for the HD molecule to have many conformations because of its 3 S-S bridges; however, it responds to various external factors by restricting conformation.
Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.
GeneRIF
Watanabe et al., Tokyo, Japan. In J Gastroenterol, 2011
Statistical analysis of gene expression showed a distinction between regions 1 and 2 of the small intestin for HD5.
Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment.
GeneRIF
Chang et al., Newark, United States. In Retrovirology, 2010
Defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment.
Enteric defensins are essential regulators of intestinal microbial ecology.
Impact
GeneRIF
Bos et al., Milwaukee, United States. In Nat Immunol, 2010
Data show that DEFA5-expressing mice had striking losses of segmented filamentous bacteria and fewer interleukin 17 (IL-17)-producing lamina propria T cells.
Hodgkin's lymphoma in elderly patients: a comprehensive retrospective analysis from the German Hodgkin's Study Group.
Impact
German Hodgkin's Study Group et al., Köln, Germany. In J Clin Oncol, 2005
PATIENTS AND METHODS: A total of 4,251 patients included in the GHSG studies HD5 to HD9 were analyzed, of whom 372 (8.8%) were 60 years or older and 3,879 (91.2%) were younger than 60 years.
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin.
Impact
GeneRIF
Bevins et al., Milwaukee, United States. In Nature, 2003
Defensin 5 transgenic mice were resistant to oral challenge with virulent Salmonella typhimurium; support for a critical in vivo role of epithelial-derived defensins in mammalian host defence
Paneth cell trypsin is the processing enzyme for human defensin-5.
Impact
GeneRIF
Bevins et al., Cleveland, United States. In Nat Immunol, 2002
By acting as a prodefensin convertase in human Paneth cells, trypsin is involved in the regulation of innate immunity in the small intestine.
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