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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Histone deacetylase 11

HD11, HDAC11
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: Histone, CAN, HDAC, HAD, HDAC10
Papers on HD11
Histone deactylase gene expression profiles are associated with outcomes in blunt trauma patients.
New
Alam et al., Copenhagen, Denmark. In J Trauma Acute Care Surg, Jan 2016
RESULTS: Elevated longitudinal HDAC expression trajectories for HDAC1, HDAC3, HDAC6, and HDAC11 were associated with complicated outcomes.
An Acute Methamphetamine Injection Downregulates the Expression of Several Histone Deacetylases (HDACs) in the Mouse Nucleus Accumbens: Potential Regulatory Role of HDAC2 Expression.
New
Cadet et al., Baltimore, United States. In Neurotox Res, Jan 2016
We found that METH decreased HDAC3, HDAC4, HDAC7, HDAC8, and HDAC11 mRNA expression but increased HDAC6 mRNA levels in the NAc of WT mice.
Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.
New
Bode et al., Heidelberg, Germany. In J Immunol, Jan 2016
Genetic studies excluded HDAC6 and HDAC10 as relevant HDAC targets in this pathway, whereas pharmacological inhibitor studies implicated the involvement of HDAC11.
Isotype-Specific Inhibition of Histone Deacetylases: Identification of Optimal Targets for Radiosensitization.
New
Kim et al., Seoul, South Korea. In Cancer Res Treat, Dec 2015
Results: Among 11 HDAC isotypes tested, specific inhibition of 7 isotypes (HDAC1, HDAC3, HDAC4, HDAC6, HDAC7, HDAC10, and HDAC11) enhanced radiation lethality in SQ20B cells.
Fimbria-Encoding Gene yadC Has a Pleiotropic Effect on Several Biological Characteristics and Plays a Role in Avian Pathogenic Escherichia coli Pathogenicity.
Dias da Silveira et al., Campinas, Brazil. In Infect Immun, 2014
Bacterial internalization studies showed that the ΔyadC strain had a lower number of intracellular bacteria recovered from Hep-2 cells and HD11 cells than the wild-type strain (P < 0.05).
Balkan nephropathy.
Review
Polenakovic et al., Скопје, Macedonia. In Clin Nephrol, 2014
SEC61G, IL17RA, and HDAC11 proved to be differently methylated throughout all patient-control pairs.
Epigenetic therapy of cancer with histone deacetylase inhibitors.
Review
Saldanha et al., Bengaluru, India. In J Cancer Res Ther, 2014
HDAC enzymes are grouped into four different classes namely Class I (HDAC1, HDAC2, HDAC3, and HDAC8), Class II (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10), Class III HDAC and Class IV (HDAC11).
Immunomodulatory effects of histone deacetylase inhibitors.
Review
Karagiannis et al., Australia. In Curr Mol Med, 2013
The recent findings highlighting the immunomodulatory function of HDAC11 which relates to balancing immune activation versus tolerance are also discussed.
ABVD in older patients with early-stage Hodgkin lymphoma treated within the German Hodgkin Study Group HD10 and HD11 trials.
Impact
Borchmann et al., Köln, Germany. In J Clin Oncol, 2013
PATIENTS AND METHODS: We analyzed the feasibility and efficacy of four cycles of ABVD in older patients age 60 to 75 years with early-stage HL who were treated within the German Hodgkin Study Group (GHSG) HD10 and HD11 trials; results were compared with those of younger patients treated within these trials.
Quality control of involved-field radiotherapy for patients with early stage Hodgkin's lymphoma based on a central prospective review. Comparison of the results between two study generations of the German Hodgkin Study Group.
Review
Eich et al., Münster, Germany. In Strahlenther Onkol, 2012
PURPOSE: Based on experience in trials HD10 and HD11 (1998-2003), the radiotherapy reference center of the German Hodgkin Study Group (GHSG) continued their central prospective radiation oncological review in trials HD13 and HD14.
Mantle cell lymphoma: a clinically heterogeneous disease in need of tailored approaches.
Review
Sotomayor et al., Tampa, United States. In Cancer Control, 2012
Molecular exploration has identified SOX11 and HDAC11 as potential candidate genes for discrimination of indolent cases.
Increased gene expression of histone deacetylases in patients with Philadelphia-negative chronic myeloproliferative neoplasms.
GeneRIF
Hasselbalch et al., Odense, Denmark. In Leuk Lymphoma, 2012
Data indicate a pronounced deregulation of HDAC genes HDAC9 and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF).
HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma.
GeneRIF
Younes et al., Houston, United States. In Blood, 2011
These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L expression.
Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.
GeneRIF
Alexandrow et al., Tampa, United States. In Cell Cycle, 2010
HDAC11 associates with replication origins inhibits Cdt1-induced re-replication and suppresses MCM loading.
Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial.
Impact
Engert et al., Köln, Germany. In J Clin Oncol, 2010
PURPOSE: Combined-modality treatment consisting of four to six cycles of chemotherapy followed by involved-field radiotherapy (IFRT) is the standard of care for patients with early unfavorable Hodgkin's lymphoma (HL).
Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis.
GeneRIF
Petri et al., Hannover, Germany. In J Neuropathol Exp Neurol, 2010
We found a reduction of HDAC 11 mRNA and increased HDAC 2 levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls.
Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.
GeneRIF
Seto et al., Tampa, United States. In J Biol Chem, 2009
Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11
From immunity to tolerance through HDAC.
Impact
Georgopoulos, United States. In Nat Immunol, 2009
Regulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in CD4+ T cells.
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance.
Impact
GeneRIF
Sotomayor et al., Tampa, United States. In Nat Immunol, 2009
HDAC11 negatively regulated expression of the gene encoding interleukin 10 in antigen-presenting cells.
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
Review
Impact
Seto et al., Montréal, Canada. In Nat Rev Mol Cell Biol, 2008
Little is known about class IV HDAC11, although its evolutionary conservation implies a fundamental role in various organisms.
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