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Vacuolar protein sorting 37 homolog A

HCRP1, hVps37A, hepatocellular carcinoma related protein 1, VPS37A
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Top mentioned proteins: TSG101, VPS28, EGFR, Vps4, ATPase
Papers on HCRP1
The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.
Woodman et al., Manchester, United Kingdom. In J Cell Sci, 2014
We map the region mediating selective assembly of UBAP1-VPS37A to the core ESCRT-I-binding domain of VPS37A.
Decreased HCRP1 expression is associated with poor prognosis in breast cancer patients.
Qin et al., Jinan, China. In Int J Clin Exp Pathol, 2013
BACKGROUND: Downregulation of hepatocellular carcinoma related protein 1 (HCRP1) has been reported to be associated with a poor prognosis in a variety of malignant tumors.
Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.
Fink, Ann Arbor, United States. In Acta Neuropathol, 2013
SPG47/AP4B1, SPG48/KIAA0415, SPG50/AP4M1, SPG51/AP4E, SPG52/AP4S1, and VSPG53/VPS37A).
HCRP1 expression status is a significant prognostic marker in oral and oropharyngeal cancer.
Filipits et al., Vienna, Austria. In Oral Dis, 2013
OBJECTIVE: The hepatocellular carcinoma-related protein 1 (HCRP1) is a key factor in the degradation of the epidermal growth factor receptor.
hVps37A Status affects prognosis and cetuximab sensitivity in ovarian cancer.
Krainer et al., Vienna, Austria. In Clin Cancer Res, 2012
Data show hVps37A mRNA downregulation in ovarian cancer.
Echovirus 1 infection depends on biogenesis of novel multivesicular bodies.
Marjomäki et al., Jyväskylä, Finland. In Cell Microbiol, 2011
Furthermore, α2-MVBs were positive for some members of ESCRTs such as Hrs, VPS37A and VPS24 and the siRNA treatment of TSG101, VPS37A and VPS24 inhibited EV1 infection.
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
Woodman et al., Manchester, United Kingdom. In Curr Biol, 2011
Mammalian ESCRT-I comprises TSG101, VPS28, VPS37A-D, and MVB12A/B.
Characterization and role of Helix contactin-related proteins in cultured Helix pomatia neurons.
Ghirardi et al., Torino, Italy. In J Neurosci Res, 2009
We focus on HCRP1 and HCRP2, soluble FNIII domains-containing proteins of 90 and 45 kD bearing consensus motifs for both N- and O-glycosylation.
Expression of the HCRP1 mRNA in HCC as an independent predictor of disease-free survival after surgical resection.
Yeh et al., Taipei, Taiwan. In Hepatol Res, 2009
AIM: Hepatocellular carcinoma (HCC)-related protein-1 (HCRP1) gene was located at chromosome 8p22, a frequently deleted region in HCC.
The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B.
Maki et al., Nagoya, Japan. In Biochem J, 2005
By the yeast two-hybrid assay, however, a positive interaction was observed with only TSG101 among the three ESCRT-I components, suggesting that ALG-2 associates with hVps28 and hVps37A indirectly through TSG101.
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation.
Stenmark et al., Oslo, Norway. In Mol Biol Cell, 2004
HCRP1 is a subunit of mammalian ESCRT-I, and its function is essential for lysosomal sorting of EGF receptors.
The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.
Sundquist et al., Salt Lake City, United States. In J Biol Chem, 2004
Bioinformatics and yeast two-hybrid screening methods were therefore used to identify four novel human proteins (VPS37A-D) that share weak but significant sequence similarity with yeast Vps37p and to demonstrate that VPS37A and VPS37B bind TSG101.
HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein.
Zhao et al., Shanghai, China. In Biochem Biophys Res Commun, 2003
Our results strongly suggest that HCRP1 might be a growth inhibitory protein and associated with decreasing the invasion of HCC cells
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