Guo et al., Wuhan, China. In Pharmacol Biochem Behav, Jan 2016
Furthermore, 2VO caused an up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) surface expressions in the hippocampal CA1 area and fluoxetine also effectively recovered the disorder of HCN2 surface expressions, which may be a possible mechanism that fluoxetine treatment ameliorates cognitive impairments in rats with CCH.
Zagotta et al., Seattle, United States. In Nat Methods, 2009
We used this 'transition metal ion FRET' approach along with X-ray crystallography to determine the structural changes of the gating ring of the mouse hyperpolarization-activated cyclic nucleotide-regulated ion channel HCN2.
Gouaux et al., Seattle, United States. In Nature, 2003
X-ray crystallographic structures of C-terminal fragment bound to cAMP or cGMP, identify a tetramerization domain and the mechanism for cyclic nucleotide specificity, and suggest a model for ligand-dependent channel modulation