Generation of cardiac pacemaker cells by programming and differentiation.
Innsbruck, Austria. In Biochim Biophys Acta, Jan 2016
The generation of pacemaker cells started with the reprogramming of adult cardiac cells by targeted induction of one pacemaker function like HCN1-4 overexpression and enclosed in an activation of single pacemaker specific transcription factors.
HCN channels--modulators of cardiac and neuronal excitability.
Erlangen, Germany. In Int J Mol Sci, 2014
The four members of this family, HCN1-4, show distinct biophysical properties which are most evident in the kinetics of activation and deactivation, the sensitivity towards cyclic nucleotides and the modulation by tyrosine phosphorylation.
Grid cells use HCN1 channels for spatial scaling.
Trondheim, Norway. In Cell, 2011
Although the dorsal-ventral gradient of the grid pattern was preserved in HCN1 knockout mice, the size and spacing of the grid fields, as well as the period of the accompanying theta modulation, was expanded at all dorsal-ventral levels.