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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hyperpolarization activated cyclic nucleotide-gated potassium channel 1

HCN1
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: HCN2, HCN4, CAN, HAD, FasT
Papers on HCN1
Morphological and physiological analysis of type-5 and other bipolar cells in the Mouse Retina.
New
Ichinose et al., Detroit, United States. In Neuroscience, Mar 2016
Furthermore, the former two types showed stronger HCN1 expression than the latter.
Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.
New
Michalakis et al., München, Germany. In Hum Mol Genet, Feb 2016
Here we explore the role of hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) in this context.
Generation of cardiac pacemaker cells by programming and differentiation.
New
Franz et al., Innsbruck, Austria. In Biochim Biophys Acta, Jan 2016
The generation of pacemaker cells started with the reprogramming of adult cardiac cells by targeted induction of one pacemaker function like HCN1-4 overexpression and enclosed in an activation of single pacemaker specific transcription factors.
Structural Changes and Lack of HCN1 Channels in the Binaural Auditory Brainstem of the Naked Mole-Rat (Heterocephalus glaber).
New
Koch et al., Berlin, Germany. In Plos One, Dec 2015
Most interestingly, binaural auditory brainstem nuclei lack the membrane-bound hyperpolarization-activated channel HCN1, a voltage-gated ion channel that greatly contributes to the fast integration times in binaural nuclei of the superior olivary complex in other species.
HCN channels--modulators of cardiac and neuronal excitability.
Review
Ludwig et al., Erlangen, Germany. In Int J Mol Sci, 2014
The four members of this family, HCN1-4, show distinct biophysical properties which are most evident in the kinetics of activation and deactivation, the sensitivity towards cyclic nucleotides and the modulation by tyrosine phosphorylation.
Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.
Tyagi et al., Pittsburgh, United States. In Bladder (san Franc), 2014
RESULTS: Expression of all four genes encoding for HCN channels (HCN1-4) was detected separately in bladder mucosa and detrusor from human and rat bladders.
Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
Impact
Siegelbaum et al., New York City, United States. In Cell, 2014
We find that Reelin signaling is required for the striking enrichment of HCN1 and GIRK1 channels in the distal tuft dendrites of both hippocampal CA1 and neocortical layer 5 pyramidal neurons, where the channels actively filter inputs targeted to these dendritic domains.
Cortical HCN channels: function, trafficking and plasticity.
Review
Shah, London, United Kingdom. In J Physiol, 2014
Four HCN subunits have been cloned, of which HCN1 and HCN2 subunits are predominantly expressed in the cortex.
De novo mutations in HCN1 cause early infantile epileptic encephalopathy.
Impact
Depienne et al., Paris, France. In Nat Genet, 2014
Studies in rat models have shown that the Hcn1 gene has a key role in epilepsy, but clinical evidence implicating HCN1 mutations in human epilepsy is lacking.
Neurophysiology of HCN channels: from cellular functions to multiple regulations.
Review
Hu et al., Chongqing, China. In Prog Neurobiol, 2014
Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are encoded by HCN1-4 gene family and have four subtypes.
HCN channels: function and clinical implications.
Review
Benarroch, Rochester, United States. In Neurology, 2013
In mammals, the HCN channel family comprises 4 members (HCN1-4) that are expressed in heart and nervous system.
Differential distribution of voltage-gated channels in myelinated and unmyelinated baroreceptor afferents.
Review
Kunze et al., Indianapolis, United States. In Auton Neurosci, 2013
Lack of a KCa current and only a limited complement of non-inactivating K(V) VGC in addition to a hyperpolarization activated HCN1 current that is nearly 10 times larger than in C-type neurons leads to elevated levels of discharge in A-type neurons, a hallmark of myelinated baroreceptors.
Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors.
GeneRIF
Johnston et al., Austin, United States. In Neuron, 2012
knockdown of HCN1 channels in the hippocampus increased cellular excitability and resulted in physiological changes
HCN1 channels significantly shape retinal photoresponses.
Review
GeneRIF
Seeliger et al., Tübingen, Germany. In Adv Exp Med Biol, 2011
Shortening and shaping of light responses by activation of HCN1 is an important step at least in the scotopic pathways.
Processing of retinal signals in normal and HCN deficient mice.
GeneRIF
Gargini et al., Pisa, Italy. In Plos One, 2011
Data show that HCN1 and HCN2 channels are expressed at distinct retinal sites and serve different functions.
Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.
GeneRIF
Bender et al., Hamburg, Germany. In Plos One, 2011
TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons.
Grid cells use HCN1 channels for spatial scaling.
Impact
GeneRIF
Moser et al., Trondheim, Norway. In Cell, 2011
Although the dorsal-ventral gradient of the grid pattern was preserved in HCN1 knockout mice, the size and spacing of the grid fields, as well as the period of the accompanying theta modulation, was expanded at all dorsal-ventral levels.
Hyperpolarization-activated cation channels: from genes to function.
Review
Impact
Zong et al., München, Germany. In Physiol Rev, 2009
In mammals, the HCN channel family comprises four members (HCN1-4) that are expressed in heart and nervous system.
Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.
Impact
Arnsten et al., New Haven, United States. In Cell, 2007
In behavioral studies, either blockade or knockdown of HCN1 channels in PFC improved WM performance.
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