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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hemopoietic cell kinase

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: Src, Lyn, Fgr, alpha-Synuclein, CAN
Papers on Hck
High-resolution antibody array analysis of childhood acute leukemia cells.
Kalina et al., Praha, Czech Republic. In Mol Cell Proteomics, Feb 2016
From non-CD markers, we found DBN1, PAX5, or PTK2 overexpressed in B-cell precursor acute lymphoblastic leukemias, LAT, SH2D1A, or STAT5A overexpressed in T-cell acute lymphoblastic leukemias, and HCK, GLUD1, or SYK overexpressed in acute myeloid leukemias.
Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration.
Pixley et al., Australia. In J Leukoc Biol, Feb 2016
Hck associated with the activated colony-stimulating factor-1 receptor, whereas Lyn associated with the receptor in a constitutive manner.
The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.
Zarbock et al., Münster, Germany. In Immunity, Feb 2016
The Src family kinase Hck, Wiskott-Aldrich-syndrome protein, and phospholipase Cγ2 were also involved in this pathway required for fMLF-triggered Mac-1 activation and neutrophil recruitment.
Hemopoietic cell kinase (Hck) and p21-activated kinase 2 (PAK2) are involved in the down-regulation of CD1a lipid antigen presentation by HIV-1 Nef in dendritic cells.
Takahashi et al., Tokyo, Japan. In Virology, Jan 2016
We demonstrated the involvement of the association of Nef with hemopoietic cell kinase (Hck) and p21-activated kinase 2 (PAK2), and that Hck, which is expressed strongly in iDCs, augmented this mutual interaction.
Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells.
Ernst et al., Melbourne, Australia. In Oncotarget, Jul 2015
The hematopoietic cell kinase (HCK) is a member of the SRC family of cytoplasmic tyrosine kinases (SFKs), and is expressed in cells of the myeloid and B-lymphocyte cell lineages.
Pyrazolopyrimidine Derivatives as Antineoplastic Agents: with a Special Focus on Thyroid Cancer.
Fallahi et al., Pisa, Italy. In Mini Rev Med Chem, 2014
In thyroid cancer (TC), PP1 and PP2 (inhibitors of RET, Hck, lck, and fynT kinases, and a good inhibitor of c-Src and platelet-derived growth factor receptor) showed antineoplastic actvity in human papillary TC cell lines that carry spontaneous RET/PTC1 rearrangements.
The role of dasatinib in the management of chronic myeloid leukemia.
Chen et al., Nanjing, China. In Drug Des Devel Ther, 2014
It potently inhibits BCR/ABL and SRC-family kinases (SRC, LCK, HCK, YES, FYN, FGR, BLK, LYN, FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase.
Hck inhibitors as potential therapeutic agents in cancer and HIV infection.
Tintori et al., Genova, Italy. In Curr Med Chem, 2014
Hematopoietic cell kinase (Hck) is a member of the Src-family of non-receptor tyrosine kinases, which plays many roles in signalling pathways involved in the regulation of cell processes.
HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via Nef.
Maridonneau-Parini et al., Toulouse, France. In Front Immunol, 2014
Indeed, the mesenchymal migration involves podosomes, and Nef stabilizes these cell structures through the activation of the tyrosine kinase Hck, which in turn phosphorylates the Wiskott-Aldrich syndrome protein (WASP).
A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma.
Wu et al., Dallas, United States. In Oncogenesis, 2014
Here we identified a Src family kinase Hck as a novel activator of Gli1.
Kinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitors.
Ichim, Toronto, Canada. In Stem Cells Transl Med, 2014
Mechanistically, Bcr-Abl is able to activate the Ras, phosphatidylinositol 3-kinase/Akt, and/or the Src-kinase Hck/Stat5 pathways in a scaffolding-dependent manner.
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix).
Morelli et al., Marseille, France. In Febs Lett, 2012
This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase.
Regulation of the hematopoietic cell kinase (HCK) by PML/RARα and PU.1 in acute promyelocytic leukemia.
Wang et al., Shanghai, China. In Leuk Res, 2012
Loss of HCK is associated with acute promyelocytic leukemia.
Hematopoietic cell kinase gene polymorphisms and the risk of chronic obstructive pulmonary disease in a Chinese population.
Yang et al., Chengdu, China. In Exp Lung Res, 2012
There were significant differences in the genotype and allele distribution of -627 G/T polymorphism in Hck gene between cases and controls.
Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1.
Horwood et al., London, United Kingdom. In J Immunol, 2012
we show that Hck, has a pre-eminent role in LPS/TLR4-induced TNF and IL-6 production.
Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.
Smithgall et al., Pittsburgh, United States. In Plos One, 2011
the activation of Hck, Lyn and c-Src by Nef is highly conserved among all major clades of HIV-1
Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.
Weiss et al., San Francisco, United States. In Immunity, 2011
Moreover, our results suggest that CD45 and CD148 preferentially target different SFK members (Hck and Fgr versus Lyn, respectively) to positively and negatively regulate GPCR pathways.
Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
Mayadas et al., Boston, United States. In Immunity, 2006
Here, in a model of thrombohemorrhagic vasculitis, the CD18 integrin Mac-1 on neutrophils recognized complement C3 deposited within vessel walls and triggered a signaling pathway involving the Src-family kinase Hck and the Syk tyrosine kinase.
The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
Lowell et al., San Francisco, United States. In Immunity, 2005
Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia.
Li et al., Bar Harbor, United States. In Nat Genet, 2004
Here, we show that Bcr-Abl activated the Src kinases Lyn, Hck and Fgr in B-lymphoid cells.
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