Update on the molecular biology of dyslipidemias.
Worcester, United Kingdom. In Clin Chim Acta, Dec 2015
Monogenic hypertriglyceridemia is the result of mutations in genes that regulate the metabolism of triglyceride rich lipoproteins (eg LPL, APOC2, APOA5, LMF1, GPIHBP1).
Physiological regulation of lipoprotein lipase.
Wageningen, Netherlands. In Biochim Biophys Acta, 2014
Upon production by the underlying parenchymal cells, LPL is transported and attached to the capillary endothelium by the protein GPIHBP1.
Ōsaka, Japan. In Nihon Rinsho, 2013
More recently, patients with primary hyperchylomicronemia caused by mutations in the gene for glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1(GPIHBP1) or lipase maturation factor 1(LMF1).
GPIHBP1: lipoprotein lipase's ticket to ride.
New York City, United States. In Cell Metab, 2010
In this issue, Davies et al. (2010) report that GPIHBP1 is required for LPL transcytosis from the basolateral to apical capillary endothelial surface.