Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators.
Campinas, Brazil. In Am J Reprod Immunol, Feb 2016
We correlated extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-8 (MMP-8), hyaluronan (HA), hyaluronidase-1 (Hyal-1), human β-defensin-2 (hBD2), and neutrophil gelatinase-associated lipocalin (NGAL) concentrations with the extent of leukocyte infiltration into the vagina and suggest their participation in vaginal inflammation.
Species-specific regulation of innate immunity by vitamin D signaling.
Montréal, Canada. In J Steroid Biochem Mol Biol, Oct 2015
Consistent with this, VDR target genes encoding AMPs human beta-defensin 2 (HBD2) and cathelicidin (CAMP) and the pattern recognition receptor NOD2 are induced by 1,25(OH)2D in human cells of epithelial or myeloid origin but not similarly regulated in mouse cells.
The host and the flora.
Tübingen, Germany. In Dig Dis, 2012
Lactobacilli, the probiotic strain Escherichia coli Nissle and Salmonella enteritica stimulate HBD-2 expression, whereas Shigella flexneri downregulates the synthesis of HBD-1, HBD-3 and LL-37.
IL-22 increases the innate immunity of tissues.
Berlin, Germany. In Immunity, 2004
In these cells, IL-22 activated STAT3 and directly and transcriptionally increased the expression of beta-Defensin 2 and beta-Defensin 3. High levels of IL-22 were associated with strongly upregulated beta-Defensin expression in skin from patients with T cell-mediated dermatoses.